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Photoacoustic (PA) imaging systems are spreading in the biomedical community, and the de-velopment of new PA contrast agents is an active area of research. However, PA contrast agents are usually characterized with spectrophotometry or…

Instrumentation and Detectors · Physics 2022-09-07 Théotim Lucas , Mitradeep Sarkar , Yoann Atlas , Clément Linger , Gilles Renault , Florence Gazeau , Jérôme Gateau

Optoacoustic tomography (OAT) is a promising modality for breast cancer diagnosis because tumor angiogenesis and, potentially, hypoxia can be visualized using quantitative OAT (qOAT) techniques. Clinically meaningful inference generally…

Medical Physics · Physics 2025-10-02 Seonyeong Park , Gangwon Jeong , Umberto Villa , Mark A. Anastasio

Photoacoustic computed tomography (PACT) is a proven technology for imaging hemodynamics in deep brain of small animal models. PACT is inherently compatible with ultrasound (US) imaging, providing complementary contrast mechanisms. While…

Instrumentation and Detectors · Physics 2023-07-28 Yuqi Tang , Zhijie Dong , Nanchao Wang , Angela del Aguila , Natalie Johnston , Tri Vu , Chenshuo Ma , Yirui Xu , Wei Yang , Pengfei Song , Junjie Yao

Photoacoustic tomography is a hybrid imaging technique that combines high optical tissue contrast with high ultrasound resolution. Direct reconstruction methods such as filtered backprojection, time reversal and least squares suffer from…

Ultrasonic phased array technology, while versatile, often requires complex computing resources and numerous amplifier components. We present a Manually Reconfigurable Phased Array that physically controls transducer position and phase,…

Applied Physics · Physics 2025-05-22 Soma Mochizuki , Yoichi Ochiai , Tatsuki Fushimi

In this article, we are concerned with a nonlinear inverse problem with a forward operator involving an unknown function. The problem arises in diverse applications and is challenging in the presence of an unknown function, which makes it…

Numerical Analysis · Mathematics 2023-02-07 Gyeongha Hwang , Gihyeon Jeon , Sunghwan Moon

Crosstalk represents a formidable obstacle in quantum computing. When quantum gates are executed parallelly, the resonance of qubit frequencies can lead to residual coupling, compromising the fidelity. Existing crosstalk solutions encounter…

Quantum Physics · Physics 2024-10-10 Bin-han Lu , Peng Wang , Zhao-yun Chen , Huan-yu Liu , Tai-ping Sun , Peng Duan , Yu-chun Wu , Guo-ping Guo

In this work we present the first application of software-defined optoelectronics (SDO) for bidimensional optoacoustic tomography (OAT). The SDO concept refers to optoelectronic systems where the functionality associated with the…

Signal Processing · Electrical Eng. & Systems 2023-05-10 Roberto Insabella , Martin Gonzalez , Lucas Riobo , Klaus Hass , Francisco Veiras

Passive acoustic mapping (PAM) is a promising tool for monitoring acoustic cavitation activities in the applications of ultrasound therapy. Data-adaptive beamformers for PAM have better image quality compared to the time exposure acoustics…

Artificial Intelligence · Computer Science 2024-12-04 Yi Zeng , Jinwei Li , Hui Zhu , Shukuan Lu , Jianfeng Li , Xiran Cai

In most photoacoustic (PA) measurements, variations in speed-of-sound (SOS) of the subject are neglected under the assumption of acoustic homogeneity. Biological tissue with spatially heterogeneous SOS cannot be accurately reconstructed…

In an inhomogeneously illuminated photoacoustic image, important information like vascular geometry is not readily available when only the initial pressure is reconstructed. To obtain the desired information, algorithms for image…

Image and Video Processing · Electrical Eng. & Systems 2019-06-19 Yoeri E. Boink , Srirang Manohar , Christoph Brune

Photoacoustic imaging (PAI) has been applied to many biomedical applications over the past decades. However, the received PA signal usually suffers from poor signal-to-noise ratio (SNR). Conventional solution of employing higher-power…

Signal Processing · Electrical Eng. & Systems 2023-07-26 Xinke Li , Peng Ge , Yuting Shen , Feng Gao , Fei Gao

Quantitative photoacoustic computed tomography (qPACT) is a promising imaging modality for estimating physiological parameters such as blood oxygen saturation. However, developing robust qPACT reconstruction methods remains challenging due…

Medical Physics · Physics 2025-10-07 Refik Mert Cam , Seonyeong Park , Umberto Villa , Mark A. Anastasio

We present a new nonlinear optimization approach for the sparse reconstruction of single-photon absorption and two-photon absorption coefficients in photoacoustic tomography (PAT). This framework comprises of minimizing an objective…

Optimization and Control · Mathematics 2020-06-30 Madhu Gupta , Rohit Kumar Mishra , Souvik Roy

As a burgeoning medical imaging method based on hybrid fusion of light and ultrasound, photoacoustic imaging (PAI) has demonstrated high potential in various biomedical applications recently, especially in revealing the functional and…

Signal Processing · Electrical Eng. & Systems 2022-11-21 Tianqu Hu , Zihao Huang , Peng Ge , Feng Gao , Fei Gao

Intracellular delivery of biomolecules remains a critical challenge in both basic cell biology and translational therapeutics. We introduce Programmable Acoustic Standing-wave Transfection (PAST), a microfluidic tool that leverages…

Biological Physics · Physics 2026-03-09 Subhas Nandy , Monica Manohar , Ashis K Sen

We study the inverse source problem in photoacoustic tomography (PAT) for mixed data, which denote a weighted linear combination of the acoustic pressure and its normal derivative on an observation surface. We consider in particular the…

Analysis of PDEs · Mathematics 2022-07-06 Florian Dreier , Markus Haltmeier

Photoacoustic computed tomography (PACT) is a rapidly emerging bioimaging modality that seeks to reconstruct an estimate of the absorbed optical energy density within an object. Conventional PACT image reconstruction methods assume a…

Medical Physics · Physics 2016-11-18 Chao Huang , Kun Wang , Robert W. Schoonover , Lihong V. Wang , Mark A. Anastasio

Quantitative Photoacoustic tomography (QPAT) is an emerging medical imaging modality which offers the possibility of combining the high resolution of the acoustic waves and large contrast of optical waves by quantifying the molecular…

Numerical Analysis · Mathematics 2014-10-30 Adriano De Cezaro , Fabiana Travessini De Cezaro

Acoustic analogue computation and signal processing are of great significance, however, it's challenging to realize the acoustic computing devices because of their limitations of single function and complex structure. In this paper, an…

Classical Physics · Physics 2020-03-25 Jun Lan , Liwei Wang , Xiaowei Zhang , Minghui Lu , Xiaozhou Liu