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Clinical imaging trials play a crucial role in advancing medical innovation but are often costly, inefficient, and ethically constrained. Virtual Imaging Trials (VITs) present a solution by simulating clinical trial components in a…

Image registration is a fundamental technique in the analysis of longitudinal and multi-phase CT images within clinical practice. However, most existing methods are tailored for single-organ applications, limiting their generalizability to…

Lung cancer stands as the preeminent cause of cancer-related mortality globally. Prompt and precise diagnosis, coupled with effective treatment, is imperative to reduce the fatality rates associated with this formidable disease. This study…

Image and Video Processing · Electrical Eng. & Systems 2024-08-29 Bitasadat Jamshidi , Nastaran Ghorbani , Mohsen Rostamy-Malkhalifeh

As early detection of breast cancer strongly favors successful therapeutic outcomes, there is major commercial interest in optimizing breast cancer screening. However, current risk prediction models achieve modest performance and do not…

Image and Video Processing · Electrical Eng. & Systems 2025-09-03 Manon A. Dorster , Felix J. Dorfner , Mason C. Cleveland , Melisa S. Guelen , Jay Patel , Dania Daye , Jean-Philippe Thiran , Albert E. Kim , Christopher P. Bridge

Pulmonary pathologies are a significant global health concern, often leading to fatal outcomes if not diagnosed and treated promptly. Chest radiography serves as a primary diagnostic tool, but the availability of experienced radiologists…

Image and Video Processing · Electrical Eng. & Systems 2024-12-17 Abdelbaki Souid , Mohamed Hamroun , Soufiene Ben Othman , Hedi Sakli , Naceur Abdelkarim

A computer-aided detection (CAD) system for the identification of pulmonary nodules in low-dose multi-detector helical Computed Tomography (CT) images with 1.25 mm slice thickness is presented. The basic modules of our lung-CAD system, a…

We introduce a new computer aided detection and diagnosis system for lung cancer screening with low-dose CT scans that produces meaningful probability assessments. Our system is based entirely on 3D convolutional neural networks and…

Computer Vision and Pattern Recognition · Computer Science 2020-01-22 Onur Ozdemir , Rebecca L. Russell , Andrew A. Berlin

Lung cancer is a devastating disease with the highest mortality rate among cancer types. Over 60% of non-small cell lung cancer (NSCLC) patients, which accounts for 87% of diagnoses, require radiation therapy. Rapid treatment initiation…

Image and Video Processing · Electrical Eng. & Systems 2024-08-02 Hamed Hooshangnejad , Xue Feng , Gaofeng Huang , Rui Zhang , Katelyn Kelly , Quan Chen , Kai Ding

Background: Voxel-based analysis (VBA) for population level radiotherapy (RT) outcomes modeling requires topology preserving inter-patient deformable image registration (DIR) that preserves tumors on moving images while avoiding unrealistic…

Image and Video Processing · Electrical Eng. & Systems 2024-11-28 Jue Jiang , Chloe Min Seo Choi , Maria Thor , Joseph O. Deasy , Harini Veeraraghavan

Background: Lung cancer was known as primary cancers and the survival rate of cancer is about 15%. Early detection of lung cancer is the leading factor in survival rate. All symptoms (features) of lung cancer do not appear until the cancer…

Artificial Intelligence · Computer Science 2016-01-26 Mitra Montazeri , Mahdieh Soleymani Baghshah , Ahmad Enhesari

Organ and cancer segmentation in abdomen Computed Tomography (CT) scans is the prerequisite for precise cancer diagnosis and treatment. Most existing benchmarks and algorithms are tailored to specific cancer types, limiting their ability to…

Image and Video Processing · Electrical Eng. & Systems 2024-08-23 Jun Ma , Yao Zhang , Song Gu , Cheng Ge , Ershuai Wang , Qin Zhou , Ziyan Huang , Pengju Lyu , Jian He , Bo Wang

Purpose: Automatic methods are required for the early detection of hepatic steatosis to avoid progression to cirrhosis and cancer. Here, we developed a fully automated deep learning pipeline to quantify hepatic steatosis on non-contrast…

Quantitative Methods · Quantitative Biology 2022-02-08 Zhongyi Zhang , Jakob Weiss , Jana Taron , Roman Zeleznik , Michael T. Lu , Hugo J. W. L. Aerts

Background: AI-based classification models are essential for improving lung cancer diagnosis. However, the relative performance of lesion-level versus chest-region models in internal and external datasets remains unclear. Purpose: This…

Image and Video Processing · Electrical Eng. & Systems 2024-11-27 Fakrul Islam Tushar

The success of deep convolutional neural networks on image classification and recognition tasks has led to new applications in very diversified contexts, including the field of medical imaging. In this paper we investigate and propose…

Computer Vision and Pattern Recognition · Computer Science 2018-02-14 Alexey A. Novikov , Dimitrios Lenis , David Major , Jiri Hladůvka , Maria Wimmer , Katja Bühler

Risk stratification (characterization) of tumors from radiology images can be more accurate and faster with computer-aided diagnosis (CAD) tools. Tumor characterization through such tools can also enable non-invasive cancer staging,…

Computer Vision and Pattern Recognition · Computer Science 2019-01-21 Sarfaraz Hussein , Pujan Kandel , Candice W. Bolan , Michael B. Wallace , Ulas Bagci

Compared with chest X-ray (CXR) imaging, which is a single image projected from the front of the patient, chest digital tomosynthesis (CDTS) imaging can be more advantageous for lung lesion detection because it acquires multiple images…

Image and Video Processing · Electrical Eng. & Systems 2022-06-29 Kyung-Su Kim , Ju Hwan Lee , Seong Je Oh , Myung Jin Chung

Lung cancer is one of the prevalence diseases in the world which cause many deaths. Detecting early stages of lung cancer is so necessary. So, modeling and simulating some intelligent medical systems is an essential which can help…

Image and Video Processing · Electrical Eng. & Systems 2023-12-07 Ehsan Sadeghi Pour , Mahdi Esmaeili

Early detection of lung cancer is crucial for effective treatment and relies on accurate volumetric assessment of pulmonary nodules in CT scans. Traditional methods, such as consolidation-to-tumor ratio (CTR) and spherical approximation,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-29 Yihan Zhou , Haocheng Huang , Yue Yu , Jianhui Shang

Liver tumor segmentation and classification are important tasks in computer aided diagnosis. We aim to address three problems: liver tumor screening and preliminary diagnosis in non-contrast computed tomography (CT), and differential…

Image and Video Processing · Electrical Eng. & Systems 2023-10-24 Ke Yan , Xiaoli Yin , Yingda Xia , Fakai Wang , Shu Wang , Yuan Gao , Jiawen Yao , Chunli Li , Xiaoyu Bai , Jingren Zhou , Ling Zhang , Le Lu , Yu Shi

Objective: Lung cancer is a leading cause of cancer-related mortality worldwide, primarily due to delayed diagnosis and poor early detection. This study aims to develop a computer-aided diagnosis (CAD) system that leverages large…

Image and Video Processing · Electrical Eng. & Systems 2025-09-16 Hafza Eman , Furqan Shaukat , Muhammad Hamza Zafar , Syed Muhammad Anwar