English
Related papers

Related papers: Pre-training Protein Language Models with Label-Ag…

200 papers

Recently, prompt tuning \cite{lester2021power} has gradually become a new paradigm for NLP, which only depends on the representation of the words by freezing the parameters of pre-trained language models (PLMs) to obtain remarkable…

Computation and Language · Computer Science 2022-01-31 Pan He , Yuxi Chen , Yan Wang , Yanru Zhang

Objective: Clinical knowledge enriched transformer models (e.g., ClinicalBERT) have state-of-the-art results on clinical NLP (natural language processing) tasks. One of the core limitations of these transformer models is the substantial…

Computation and Language · Computer Science 2023-01-30 Yikuan Li , Ramsey M. Wehbe , Faraz S. Ahmad , Hanyin Wang , Yuan Luo

Language model (LM) pre-training has resulted in impressive performance and sample efficiency on a variety of language understanding tasks. However, it remains unclear how to best use pre-trained LMs for generation tasks such as abstractive…

Computation and Language · Computer Science 2019-05-23 Urvashi Khandelwal , Kevin Clark , Dan Jurafsky , Lukasz Kaiser

Representation learning and \emph{de novo} generation of proteins are pivotal computational biology tasks. Whilst natural language processing (NLP) techniques have proven highly effective for protein sequence modelling, structure modelling…

Quantitative Methods · Quantitative Biology 2025-01-08 Benoit Gaujac , Jérémie Donà , Liviu Copoiu , Timothy Atkinson , Thomas Pierrot , Thomas D. Barrett

Deep neural models (e.g. Transformer) naturally learn spurious features, which create a ``shortcut'' between the labels and inputs, thus impairing the generalization and robustness. This paper advances the self-attention mechanism to its…

Computation and Language · Computer Science 2023-02-09 Hongqiu Wu , Ruixue Ding , Hai Zhao , Pengjun Xie , Fei Huang , Min Zhang

Masked language modeling, widely used in discriminative language model (e.g., BERT) pretraining, commonly adopts a random masking strategy. However, random masking does not consider the importance of the different words in the sentence…

Computation and Language · Computer Science 2023-05-25 Qihuang Zhong , Liang Ding , Juhua Liu , Bo Du , Dacheng Tao

Many recent models in software engineering introduced deep neural models based on the Transformer architecture or use transformer-based Pre-trained Language Models (PLM) trained on code. Although these models achieve the state of the arts…

Software Engineering · Computer Science 2022-04-22 Rishab Sharma , Fuxiang Chen , Fatemeh Fard , David Lo

Transformer language models (TLMs) are critical for most NLP tasks, but they are difficult to create for low-resource languages because of how much pretraining data they require. In this work, we investigate two techniques for training…

Computation and Language · Computer Science 2023-01-06 Luke Gessler , Amir Zeldes

Prevalent supervised learning methods in natural language processing (NLP) are notoriously data-hungry, which demand large amounts of high-quality annotated data. In practice, acquiring such data is a costly endeavor. Recently, the superior…

Computation and Language · Computer Science 2023-11-01 Ruoyu Zhang , Yanzeng Li , Yongliang Ma , Ming Zhou , Lei Zou

Transformer-based large language models (LLMs) have achieved strong performance across many natural language processing tasks. Nonetheless, their quadratic computational and memory requirements, particularly in self-attention layers, pose…

Computation and Language · Computer Science 2025-09-03 Fabien Furfaro

Fine-tuning BERT-based models is resource-intensive in memory, computation, and time. While many prior works aim to improve inference efficiency via compression techniques, e.g., pruning, these works do not explicitly address the…

Computation and Language · Computer Science 2022-08-04 Danilo Vucetic , Mohammadreza Tayaranian , Maryam Ziaeefard , James J. Clark , Brett H. Meyer , Warren J. Gross

We study the problem of leveraging the syntactic structure of text to enhance pre-trained models such as BERT and RoBERTa. Existing methods utilize syntax of text either in the pre-training stage or in the fine-tuning stage, so that they…

Computation and Language · Computer Science 2021-06-01 Zenan Xu , Daya Guo , Duyu Tang , Qinliang Su , Linjun Shou , Ming Gong , Wanjun Zhong , Xiaojun Quan , Nan Duan , Daxin Jiang

We introduce a protein language model for determining the complete sequence of a peptide based on measurement of a limited set of amino acids. To date, protein sequencing relies on mass spectrometry, with some novel edman degregation based…

One reason pretraining on self-supervised linguistic tasks is effective is that it teaches models features that are helpful for language understanding. However, we want pretrained models to learn not only to represent linguistic features,…

Computation and Language · Computer Science 2020-10-13 Alex Warstadt , Yian Zhang , Haau-Sing Li , Haokun Liu , Samuel R. Bowman

Protein language models (pLMs) have demonstrated success at generating functional proteins across vast sequence spaces but lack the ability to design high-fitness variants on demand. Here, we iteratively guide pLMs toward user-defined…

Biomolecules · Quantitative Biology 2025-12-01 Filippo Stocco , Maria Artigues-Lleixa , Andrea Hunklinger , Talal Widatalla , Marc Guell , Noelia Ferruz

The introduction of Large Language Models (LLMs), and the vast volume of publicly available medical data, amplified the application of NLP to the medical domain. However, LLMs are pretrained on data that are not explicitly relevant to the…

Computation and Language · Computer Science 2023-12-12 Chris Solomou

Over the past six years, molecular transformer models have become key tools in drug discovery. Most existing models are pre-trained on large, unlabeled datasets such as ZINC or ChEMBL. However, the extent to which large-scale pre-training…

Machine Learning · Computer Science 2025-05-23 Afnan Sultan , Max Rausch-Dupont , Shahrukh Khan , Olga Kalinina , Dietrich Klakow , Andrea Volkamer

Active learning strives to reduce annotation costs by choosing the most critical examples to label. Typically, the active learning strategy is contingent on the classification model. For instance, uncertainty sampling depends on poorly…

Computation and Language · Computer Science 2020-10-26 Michelle Yuan , Hsuan-Tien Lin , Jordan Boyd-Graber

Masked language models (MLMs) such as BERT and RoBERTa have revolutionized the field of Natural Language Understanding in the past few years. However, existing pre-trained MLMs often output an anisotropic distribution of token…

Computation and Language · Computer Science 2022-04-29 Yixuan Su , Fangyu Liu , Zaiqiao Meng , Tian Lan , Lei Shu , Ehsan Shareghi , Nigel Collier

Transformer-based language models, more specifically BERT-based architectures have achieved state-of-the-art performance in many downstream tasks. However, for a relatively low-resource language such as Thai, the choices of models are…

Computation and Language · Computer Science 2021-03-23 Lalita Lowphansirikul , Charin Polpanumas , Nawat Jantrakulchai , Sarana Nutanong