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Pre-training a language model and then fine-tuning it for downstream tasks has demonstrated state-of-the-art results for various NLP tasks. Pre-training is usually independent of the downstream task, and previous works have shown that this…

Computation and Language · Computer Science 2022-11-28 Tanish Lad , Himanshu Maheshwari , Shreyas Kottukkal , Radhika Mamidi

Large pretrained language models have transformed natural language processing, and their adaptation to protein sequences -- viewed as strings of amino acid characters -- has advanced protein analysis. However, the distinct properties of…

Other Quantitative Biology · Quantitative Biology 2025-10-14 Sheikh Azizul Hakim , Kowshic Roy , M Saifur Rahman

Large language models (LLMs) are increasingly deployed in specialized domains such as finance, medicine, and agriculture, where they face significant distribution shifts from their training data. Domain-specific fine-tuning can mitigate…

Computation and Language · Computer Science 2026-03-26 Yijie Xu , Huizai Yao , Zhiyu Guo , Pengteng Li , Aiwei Liu , Xuming Hu , Weiyu Guo , Hui Xiong

Understanding the binding specificity between T-cell receptors (TCRs) and peptide-major histocompatibility complexes (pMHCs) is central to immunotherapy and vaccine development. However, current predictive models struggle with…

Quantitative Methods · Quantitative Biology 2025-12-29 Cong Qi , Hanzhang Fang , Siqi jiang , Tianxing Hu , Zhi Wei

Linguistic sequence labeling is a general modeling approach that encompasses a variety of problems, such as part-of-speech tagging and named entity recognition. Recent advances in neural networks (NNs) make it possible to build reliable…

Computation and Language · Computer Science 2017-11-27 Liyuan Liu , Jingbo Shang , Frank F. Xu , Xiang Ren , Huan Gui , Jian Peng , Jiawei Han

Pre-trained models are widely used in the tasks of natural language processing nowadays. However, in the specific field of text simplification, the research on improving pre-trained models is still blank. In this work, we propose a…

Computation and Language · Computer Science 2022-04-19 Renliang Sun , Xiaojun Wan

End-to-end spoken language understanding (SLU) systems benefit from pretraining on large corpora, followed by fine-tuning on application-specific data. The resulting models are too large for on-edge applications. For instance, BERT-based…

Computation and Language · Computer Science 2022-06-30 Pu Wang , Hugo Van hamme

Pre-trained language model representations have been successful in a wide range of language understanding tasks. In this paper, we examine different strategies to integrate pre-trained representations into sequence to sequence models and…

Computation and Language · Computer Science 2019-04-02 Sergey Edunov , Alexei Baevski , Michael Auli

Chinese sequence labeling tasks are heavily reliant on accurate word boundary demarcation. Although current pre-trained language models (PLMs) have achieved substantial gains on these tasks, they rarely explicitly incorporate boundary…

Computation and Language · Computer Science 2024-04-09 Longhui Zhang , Dingkun Long , Meishan Zhang , Yanzhao Zhang , Pengjun Xie , Min Zhang

Existing Protein Language Models (PLMs) often suffer from limited adaptability to multiple tasks and exhibit poor generalization across diverse biological contexts. In contrast, general-purpose Large Language Models (LLMs) lack the…

Machine Learning · Computer Science 2026-02-23 Yujia Wang , Jihong Guan , Wengen Li , Shuigeng Zhou , Xuhong Wang

Pretrained language models based on the transformer architecture have shown great success in NLP. Textual training data often comes from the web and is thus tagged with time-specific information, but most language models ignore this…

Computation and Language · Computer Science 2022-05-05 Guy D. Rosin , Kira Radinsky

Large language models (LLMs) have shown promise in various natural language processing tasks, including their application to proteomics data to classify protein fragments. In this study, we curated a limited mass spectrometry dataset with…

Quantitative Methods · Quantitative Biology 2025-02-28 Taylor A Phillips , Alejandro W. Huskey , Patrick T. Huskey , Seth L. Robia , Peter M. Kekenes-Huskey

Large pre-trained language models help to achieve state of the art on a variety of natural language processing (NLP) tasks, nevertheless, they still suffer from forgetting when incrementally learning a sequence of tasks. To alleviate this…

Computation and Language · Computer Science 2023-03-03 Mingxu Tao , Yansong Feng , Dongyan Zhao

Accurately measuring protein-RNA binding affinity is crucial in many biological processes and drug design. Previous computational methods for protein-RNA binding affinity prediction rely on either sequence or structure features, unable to…

Biomolecules · Quantitative Biology 2025-01-06 Rong Han , Xiaohong Liu , Tong Pan , Jing Xu , Xiaoyu Wang , Wuyang Lan , Zhenyu Li , Zixuan Wang , Jiangning Song , Guangyu Wang , Ting Chen

Speech emotion recognition (SER) models typically rely on costly human-labeled data for training, making scaling methods to large speech datasets and nuanced emotion taxonomies difficult. We present LanSER, a method that enables the use of…

Computation and Language · Computer Science 2023-09-11 Taesik Gong , Josh Belanich , Krishna Somandepalli , Arsha Nagrani , Brian Eoff , Brendan Jou

Language models (LMs) have demonstrated remarkable capabilities in NLP, yet adapting them efficiently and robustly to specific tasks remains challenging. As their scale and complexity grow, fine-tuning LMs on labelled data often…

Computation and Language · Computer Science 2025-06-27 Zhengyan Shi

Recently, Transformer-based language models have demonstrated remarkable performance across many NLP domains. However, the unsupervised pre-training step of these models suffers from unbearable overall computational expenses. Current…

Machine Learning · Computer Science 2020-10-27 Minjia Zhang , Yuxiong He

The ubiquity of smart voice assistants has made conversational shopping commonplace. This is especially true for low consideration segments like grocery. A central problem in conversational grocery is the automatic generation of short…

Computation and Language · Computer Science 2020-12-15 Snehasish Mukherjee , Phaniram Sayapaneni , Shankar Subramanya

Language models typically need to be trained or finetuned in order to acquire new knowledge, which involves updating their weights. We instead envision language models that can simply read and memorize new data at inference time, thus…

Machine Learning · Computer Science 2022-03-18 Yuhuai Wu , Markus N. Rabe , DeLesley Hutchins , Christian Szegedy

Building a good speech recognition system usually requires large amounts of transcribed data, which is expensive to collect. To tackle this problem, many unsupervised pre-training methods have been proposed. Among these methods, Masked…

Audio and Speech Processing · Electrical Eng. & Systems 2020-06-24 Dongwei Jiang , Wubo Li , Ruixiong Zhang , Miao Cao , Ne Luo , Yang Han , Wei Zou , Xiangang Li
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