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Identification of abnormalities in red blood cells (RBC) is key to diagnosing a range of medical conditions from anaemia to liver disease. Currently this is done manually, a time-consuming and subjective process. This paper presents an…

Computer Vision and Pattern Recognition · Computer Science 2021-06-02 Annika Wong , Nantheera Anantrasirichai , Thanarat H. Chalidabhongse , Duangdao Palasuwan , Attakorn Palasuwan , David Bull

Digital pathology has recently been revolutionized by advancements in artificial intelligence, deep learning, and high-performance computing. With its advanced tools, digital pathology can help improve and speed up the diagnostic process,…

Image and Video Processing · Electrical Eng. & Systems 2024-03-28 Mohamed Elmanna , Ahmed Elsafty , Yomna Ahmed , Muhammad Rushdi , Ahmed Morsy

Morphologies of red blood cells are normally interpreted by a pathologist. It is time-consuming and laborious. Furthermore, a misclassified red blood cell morphology will lead to false disease diagnosis and improper treatment. Thus, a…

Image and Video Processing · Electrical Eng. & Systems 2025-02-06 Kitsuchart Pasupa , Supawit Vatathanavaro , Suchat Tungjitnob

Accurate classification of blood cells plays a key role in improving automated blood analysis for both medical and veterinary applications. This work presents a two-stage deep clustering method for classifying blood cells from…

Quantitative Methods · Quantitative Biology 2025-09-25 Mihaela Macarie-Ancau , Adrian Groza

Cell detection and cell type classification from biomedical images play an important role for high-throughput imaging and various clinical application. While classification of single cell sample can be performed with standard computer…

Image and Video Processing · Electrical Eng. & Systems 2019-12-17 Wei Qiu , Jiaming Guo , Xiang Li , Mengjia Xu , Mo Zhang , Ning Guo , Quanzheng Li

We present WBCBench 2026, an ISBI challenge and benchmark for automated WBC classification designed to stress-test algorithms under three key difficulties: (i) severe class imbalance across 13 morphologically fine-grained WBC classes, (ii)…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Xin Tian , Xudong Ma , Tianqi Yang , Alin Achim , Bartłomiej W Papież , Phandee Watanaboonyongcharoen , Nantheera Anantrasirichai

Blood cell classification and counting are vital for the diagnosis of various blood-related diseases, such as anemia, leukemia, and thrombocytopenia. The manual process of blood cell classification and counting is time-consuming, prone to…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Sohag Kumar Mondal , Md. Simul Hasan Talukder , Mohammad Aljaidi , Rejwan Bin Sulaiman , Md Mohiuddin Sarker Tushar , Amjad A Alsuwaylimi

Automated white blood cell (WBC) classification is essential for leukemia screening but remains challenged by extreme class imbalance, long-tail distributions, and domain shift, leading deep models to overfit dominant classes and fail on…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Duc T. Nguyen , Hoang-Long Nguyen , Huy-Hieu Pham

Highly imbalanced datasets are ubiquitous in medical image classification problems. In such problems, it is often the case that rare classes associated to less prevalent diseases are severely under-represented in labeled databases,…

Computer Vision and Pattern Recognition · Computer Science 2022-09-15 Adrian Galdran , Gustavo Carneiro , Miguel A. González Ballester

White blood cell (WBC) classification is fundamental for hematology applications such as infection assessment, leukemia screening, and treatment monitoring. However, real-world WBC datasets present substantial appearance variations caused…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Luu Le , Hoang-Loc Cao , Ha-Hieu Pham , Thanh-Huy Nguyen , Ulas Bagci

This paper proposes a novel automatic classification framework for the recognition of five types of white blood cells. Segmenting complete white blood cells from blood smears images and extracting advantageous features from them remain…

Computer Vision and Pattern Recognition · Computer Science 2020-09-07 Na Dong , Meng-die Zhai , Jian-fang Chang , Chun-ho Wu

Class imbalance, where certain classes have insufficient data, poses a critical challenge for robust classification, often biasing models toward majority classes. Distribution calibration offers a promising avenue to address this by…

Machine Learning · Computer Science 2025-10-23 Priyobrata Mondal , Faizanuddin Ansari , Swagatam Das

Machine learning (ML) and deep learning (DL) models have been employed to significantly improve analyses of medical imagery, with these approaches used to enhance the accuracy of prediction and classification. Model predictions and…

Image and Video Processing · Electrical Eng. & Systems 2023-08-22 Rabia Asghar , Sanjay Kumar , Paul Hynds , Arslan Shaukat

The automatic detection of White Blood Cells (WBC) still remains as an unsolved issue in medical imaging. The analysis of WBC images has engaged researchers from fields of medicine and computer vision alike. Since WBC can be approximated by…

Computer Vision and Pattern Recognition · Computer Science 2014-06-30 Erik Cuevas , Margarita Diaz , Miguel Manzanares , Daniel Zaldivar , Marco Perez

Red blood cell (RBC) deformation is the consequence of several diseases, including sickle cell anemia, which causes recurring episodes of pain and severe pronounced anemia. Monitoring patients with these diseases involves the observation of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Wilkie Delgado-Font , Miriela Escobedo-Nicot , Manuel González-Hidalgo , Silena Herold-Garcia , Antoni Jaume-i-Capó , Arnau Mir

Accurately classifying white blood cells from microscopic images is essential to identify several illnesses and conditions in medical diagnostics. Many deep learning technologies are being employed to quickly and automatically classify…

Image and Video Processing · Electrical Eng. & Systems 2025-08-07 Tatwadarshi P. Nagarhalli , Shruti S. Pawar , Soham A. Dahanukar , Uday Aswalekar , Ashwini M. Save , Sanket D. Patil

Deep learning models have gained remarkable performance on a variety of image classification tasks. However, many models suffer from limited performance in clinical or medical settings when data are imbalanced. To address this challenge, we…

Image and Video Processing · Electrical Eng. & Systems 2022-04-15 Long Gao , Chang Liu , Dooman Arefan , Ashok Panigrahy , Margarita L. Zuley , Shandong Wu

Precise breast cancer classification on histopathological images has the potential to greatly improve the diagnosis and patient outcome in oncology. The data imbalance problem largely stems from the inherent imbalance within medical image…

Image and Video Processing · Electrical Eng. & Systems 2024-11-28 Majid Behzadpour , Bengie L. Ortiz , Ebrahim Azizi , Kai Wu

Accurate morphological classification of white blood cells (WBCs) is an important step in the diagnosis of leukemia, a disease in which nonfunctional blast cells accumulate in the bone marrow. Recently, deep convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Rao Muhammad Umer , Armin Gruber , Sayedali Shetab Boushehri , Christian Metak , Carsten Marr

creating automated processes in different areas of medical science with the application of engineering tools is a highly growing field over recent decades. In this context, many medical image processing and analyzing researchers use…

Computer Vision and Pattern Recognition · Computer Science 2019-07-17 Hamed Talebi , Amin Ranjbar , Alireza Davoudi , Hamed Gholami , Mohammad Bagher Menhaj
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