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Motivated by the desire to exploit patterns shared across classes, we present a simple yet effective class-specific memory module for fine-grained feature learning. The memory module stores the prototypical feature representation for each…

Computer Vision and Pattern Recognition · Computer Science 2020-12-15 Weijian Deng , Joshua Marsh , Stephen Gould , Liang Zheng

Challenges of assessing complexity and clonality in populations of mixed species arise in diverse areas of modern biology, including estimating diversity and clonality in microbiome populations, measuring patterns of T and B cell clonality,…

Methodology · Statistics 2014-08-07 Yi Liu , Andrew Z. Fire , Scott Boyd , Richard A. Olshen

One of the key phenomena in the adaptive immune response to infection and immunization is affinity maturation, during which antibody genes are mutated and selected, typically resulting in a substantial increase in binding affinity to the…

Quantitative Methods · Quantitative Biology 2013-03-05 Thomas B. Kepler

We present an attention-based model for recognizing multiple objects in images. The proposed model is a deep recurrent neural network trained with reinforcement learning to attend to the most relevant regions of the input image. We show…

Machine Learning · Computer Science 2015-04-24 Jimmy Ba , Volodymyr Mnih , Koray Kavukcuoglu

The detection of induced pluripotent stem cell (iPSC) colonies often needs the precise extraction of the colony features. However, existing computerized systems relied on segmentation of contours by preprocessing for classifying the colony…

Image and Video Processing · Electrical Eng. & Systems 2022-03-10 Novanto Yudistira , Muthu Subash Kavitha , Jeny Rajan , Takio Kurita

Under the impact of global climate changes and human activities, harmful algae blooms in surface waters have become a growing concern due to negative impacts on water related industries. Therefore, reliable and cost effective methods of…

Computer Vision and Pattern Recognition · Computer Science 2018-10-26 Jason L. Deglint , Chao Jin , Alexander Wong

We present a machine learning approach that leverages persistent homology to classify bacterial flagellar motors into two functional states: rotated and stalled. By embedding protein structural data into a topological framework, we extract…

Biomolecules · Quantitative Biology 2025-12-19 Zakaria Lamine , Abdelatif Hafid , Mohamed Rahouti

While deep learning has shown promise in the domain of disease classification from medical images, models based on state-of-the-art convolutional neural network architectures often exhibit performance loss due to dataset shift. Models…

Machine Learning · Computer Science 2020-01-14 Joseph D. Janizek , Gabriel Erion , Alex J. DeGrave , Su-In Lee

Persistent homology enables fast and computable comparison of topological objects. However, it is naturally limited to the analysis of topological spaces. We extend the theory of persistence, by guaranteeing robustness and computability to…

Combinatorics · Mathematics 2020-09-16 Mattia G. Bergomi , Massimo Ferri , Pietro Vertechi , Lorenzo Zuffi

Explainability is a key requirement for computer-aided diagnosis systems in clinical decision-making. Multiple instance learning with attention pooling provides instance-level explainability, however for many clinical applications a deeper,…

Image and Video Processing · Electrical Eng. & Systems 2023-03-16 Ario Sadafi , Oleksandra Adonkina , Ashkan Khakzar , Peter Lienemann , Rudolf Matthias Hehr , Daniel Rueckert , Nassir Navab , Carsten Marr

Whole-slide image classification represents a key challenge in computational pathology and medicine. Attention-based multiple instance learning (MIL) has emerged as an effective approach for this problem. However, the effect of attention…

Quantitative Methods · Quantitative Biology 2025-03-14 Rajiv Krishnakumar , Julien Baglio , Frederik F. Flöther , Christian Ruiz , Stefan Habringer , Nicole H. Romano

We present a computational live bacteria detection system that periodically captures coherent microscopy images of bacterial growth inside a 60 mm diameter agar-plate and analyzes these time-lapsed holograms using deep neural networks for…

Persistence has proved to be a valuable tool to analyze real world data robustly. Several approaches to persistence have been attempted over time, some topological in flavor, based on the vector space-valued homology functor, other…

Algebraic Topology · Mathematics 2019-05-23 Mattia G. Bergomi , Pietro Vertechi

Pneumonia is a life-threatening disease, which occurs in the lungs caused by either bacterial or viral infection. It can be life-endangering if not acted upon in the right time and thus an early diagnosis of pneumonia is vital. The aim of…

Image and Video Processing · Electrical Eng. & Systems 2020-05-08 Tawsifur Rahman , Muhammad E. H. Chowdhury , Amith Khandakar , Khandaker R. Islam , Khandaker F. Islam , Zaid B. Mahbub , Muhammad A. Kadir , Saad Kashem

Neural networks with relatively shallow layers and simple structures may have limited ability in accurately identifying pneumonia. In addition, deep neural networks also have a large demand for computing resources, which may cause…

Image and Video Processing · Electrical Eng. & Systems 2024-06-14 Houze Liu , Iris Li , Yaxin Liang , Dan Sun , Yining Yang , Haowei Yang

In this work, we investigate the performance across multiple classification models to classify chest X-ray images into four categories of COVID-19, pneumonia, tuberculosis (TB), and normal cases. We leveraged transfer learning techniques…

Image and Video Processing · Electrical Eng. & Systems 2025-05-29 Alanna Hazlett , Naomi Ohashi , Timothy Rodriguez , Sodiq Adewole

The clonal selection principle explains the basic features of an adaptive immune response to a antigenic stimulus. It established the idea that only those cells that recognize the antigens are selected to proliferate and differentiate. This…

Neural and Evolutionary Computing · Computer Science 2018-04-10 Takumi Ichimura , Shin Kamada

Code clone is a serious problem in software and has the potential to software defects, maintenance overhead, and licensing violations. Therefore, clone detection is important for reducing maintenance effort and improving code quality during…

Software Engineering · Computer Science 2020-10-12 Min Fu , Gang Luo , Xi Zheng , Tianyi Zhang , Dongjin Yu , Miryung Kim

Continual Learning (CL) is crucial for enabling networks to dynamically adapt as they learn new tasks sequentially, accommodating new data and classes without catastrophic forgetting. Diverging from conventional perspectives on CL, our…

Image and Video Processing · Electrical Eng. & Systems 2024-07-12 Nourhan Bayasi , Jamil Fayyad , Alceu Bissoto , Ghassan Hamarneh , Rafeef Garbi

Preliminary diagnosis of fungal infections can rely on microscopic examination. However, in many cases, it does not allow unambiguous identification of the species by microbiologist due to their visual similarity. Therefore, it is usually…

Computer Vision and Pattern Recognition · Computer Science 2020-09-09 Bartosz Zieliński , Agnieszka Sroka-Oleksiak , Dawid Rymarczyk , Adam Piekarczyk , Monika Brzychczy-Włoch