Related papers: Pulmonary drug delivery and retention: a computati…
Local drug delivery has received much recognition in recent years, yet it is still unpredictable how drug efficacy depends on physicochemical properties and delivery kinetics. The purpose of the current study is to provide a useful…
The big crux with drug delivery to human lungs is that the delivered dose at the local site of action is unpredictable and very difficult to measure, even a posteriori. It is highly subject-specific as it depends on lung morphology,…
For the one billion sufferers of respiratory disease, managing their disease with inhalers crucially influences their quality of life. Generic treatment plans could be improved with the aid of computational models that account for…
The deposition of micron particles finds importance in meteorology and several engineering applications such as deposition of dust in gas lines, carbon deposition in engine exhaust, designing effective air-cleaning systems and estimating…
Improving the efficacy of nasal sprays by enhancing targeted drug delivery to intra-airway tissue sites prone to infection onset is hypothesized to be achievable through an optimization of key device and formulation parameters, such as the…
Inhalers spray over 100 million drug particles into the mouth, where a significant portion of the drug may deposit. Understanding how the complex interplay between particle and solid phases influence deposition is crucial for optimising…
This paper considers the scenario of a targeted drug delivery system, which consists of deploying a number of biological nanomachines close to a biological target (e.g. a tumor), able to deliver drug molecules in the diseased area. Suitably…
In this work we develop and investigate mathematical and computational models that describe drug delivery from a contact lens during wear. Our models are designed to predict the dynamics of drug release from the contact lens and subsequent…
We propose a mathematical model for computing drug release from multi-layer capsules. The diffusion problem in such heterogeneous layer-by-layer composite medium is described by a system of coupled partial differential equations, which we…
Airway constriction and blockage in obstructive lung diseases cause ventilation heterogeneity and create barriers to effective drug deposition. Established computational particle-deposition models have not accounted for these impacts of…
We study the transport and deposition of inhaled aerosols in a mid-generation, mucus-lined lung airway, with the aim of understanding if and how airborne particles can avoid the mucus and deposit on the airway wall -- an outcome that is…
Electroporation is a very useful tool for drug delivery into various diseased tissues of the human body. This technique helps to improve the clinical treatment by transferring drugs into the targeted cells rapidly. In electroporation, drug…
One of the promising frontiers of bioengineering is the controlled release of a therapeuticdrug from a vehicle across the skin (transdermal drug delivery). In order to study the complete process, a two-phase mathematical model describing…
A model that predicts the outcome of collisions between droplets and particles in terms of the distribution of the droplet volume post-collision is lacking, in contrast to the case for droplet-droplet interactions. Taking existing models…
We present a mechanistic model of drug release from a multiple emulsion into an external surrounding fluid. We consider a single multi-layer droplet where the drug kinetics are described by a pure diffusive process through different liquid…
Drug delivery systems represent a promising strategy to treat cancer and to overcome the side effects of chemotherapy. In particular, polymeric nanocontainers have attracted major interest because of their structural and morphological…
The transport of virus-laden aerosols from a host to a susceptible person is governed by complex turbulent airflow, and physics related to breathing, coughing and sneezing, mechanical and passive ventilation, thermal buoyancy effects,…
Drug delivery through electroporation could be highly beneficial for the treatment of different types of diseased tissues within the human body. In this work, a mathematical model of reversible tissue electroporation is presented for…
In this study, a computational simulation is employed to place two essential parameters, the permeability of vessels and hydraulic conductivity, under assessment. These parameters impact the movement of drug particles through vessels, and…
Investigations on airborne transmission of pathogens constitute a rapidly expanding field, primarily focused on understanding the expulsion patterns of respiratory particulates from infected hosts and their dispersion in confined spaces.…