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Despite the growing use of Electronic Health Records (EHR) for AI-assisted diagnosis prediction, most data-driven models struggle to incorporate clinically meaningful medical knowledge. They often rely on limited ontologies, lacking…

Machine Learning · Computer Science 2025-04-17 Pengfei Hu , Chang Lu , Fei Wang , Yue Ning

The TADPOLE Challenge compares the performance of algorithms at predicting the future evolution of individuals at risk of Alzheimer's disease. TADPOLE Challenge participants train their models and algorithms on historical data from the…

The novel 2019 Coronavirus disease (COVID-19) global pandemic is a defining health crisis. Recent efforts have been increasingly directed towards achieving quick and accurate detection of COVID-19 across symptomatic patients to mitigate the…

Image and Video Processing · Electrical Eng. & Systems 2023-11-27 Karina Yang , Alexis Bennett , Dominique Duncan

Risk prediction capitalizing on emerging human genome findings holds great promise for new prediction and prevention strategies. While the large amounts of genetic data generated from high-throughput technologies offer us a unique…

Methodology · Statistics 2021-01-29 Xiaoxi Shen , Xiaoran Tong , Qing Lu

It is difficult or infeasible to directly measure how much of a drug actually enters the human brain and a brain tumor, how long it remains there, and to estimate drug-specific or patient-specific parameters, as well as how changes in these…

Dynamical Systems · Mathematics 2026-03-13 Charuka D. Wickramasinghe , Nelum S. S. M. Hapuhinna

In the rapidly evolving landscape of medical imaging diagnostics, achieving high accuracy while preserving computational efficiency remains a formidable challenge. This work presents \texttt{DeepMediX}, a groundbreaking, resource-efficient…

Computer Vision and Pattern Recognition · Computer Science 2023-07-04 Kishore Babu Nampalle , Pradeep Singh , Uppala Vivek Narayan , Balasubramanian Raman

In critical decision support systems based on medical imaging, the reliability of AI-assisted decision-making is as relevant as predictive accuracy. Although deep learning models have demonstrated significant accuracy, they frequently…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Hua Xu , Julián D. Arias-Londoño , Juan I. Godino-Llorente

Accurate skin cancer diagnosis is vital for early treatment and improved patient outcomes. Deep learning (DL) models have shown promise in automating skin cancer classification, yet challenges remain due to data scarcity and limited…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Hamzeh Asgharnezhad , Pegah Tabarisaadi , Abbas Khosravi , Roohallah Alizadehsani , U. Rajendra Acharya

The full acceptance of Deep Learning (DL) models in the clinical field is rather low with respect to the quantity of high-performing solutions reported in the literature. Particularly, end users are reluctant to rely on the rough…

Image and Video Processing · Electrical Eng. & Systems 2022-10-11 Benjamin Lambert , Florence Forbes , Alan Tucholka , Senan Doyle , Harmonie Dehaene , Michel Dojat

Deep learning (DL) and machine learning (ML) models have shown promise in drug response prediction (DRP), yet their ability to generalize across datasets remains an open question, raising concerns about their real-world applicability. Due…

Purpose: Development of a novel interactive visualization approach for the exploration of radiotherapy treatment plans with a focus on overlap volumes with the aim of healthy tissue sparing. Methods: We propose a visualization approach to…

Human-Computer Interaction · Computer Science 2023-10-03 Matthias Schlachter , Samuel Peters , Daniel Camenisch , Paul Martin Putora , Katja Bühler

We propose an adaptive design for early phase drug combination cancer trials with the goal of estimating the maximum tolerated dose (MTD). A nonparametric Bayesian model, using beta priors truncated to the set of partially ordered dose…

Applications · Statistics 2019-10-22 Zahra S. Razaee , Galen Wien-Cook , Mourad Tighiouart

Developing generalizable AI for medical imaging requires both access to large, multi-center datasets and standardized, reproducible tooling within research environments. However, leveraging real-world imaging data in clinical research…

Computer Vision and Pattern Recognition · Computer Science 2025-12-11 Ünal Akünal , Markus Bujotzek , Stefan Denner , Benjamin Hamm , Klaus Kades , Philipp Schader , Jonas Scherer , Marco Nolden , Peter Neher , Ralf Floca , Klaus Maier-Hein

Concept bottleneck models (CBMs), which predict human-interpretable concepts (e.g., nucleus shapes in cell images) before predicting the final output (e.g., cell type), provide insights into the decision-making processes of the model.…

Computer Vision and Pattern Recognition · Computer Science 2024-07-10 Winnie Pang , Xueyi Ke , Satoshi Tsutsui , Bihan Wen

An automated knowledge modeling algorithm for Cancer Clinical Practice Guidelines (CPGs) extracts the knowledge contained in the CPG documents and transforms it into a programmatically interactable, easy-to-update structured model with…

Computation and Language · Computer Science 2024-08-01 Pralaypati Ta , Bhumika Gupta , Arihant Jain , Sneha Sree C , Keerthi Ram , Mohanasankar Sivaprakasam

Treatment planning is currently a patient specific, time-consuming, and resource demanding task in radiotherapy. Dose-volume histogram (DVH) prediction plays a critical role in automating this process. The geometric relationship between…

Artificial Intelligence · Computer Science 2024-02-13 Zehao Dong , Yixin Chen , Hiram Gay , Yao Hao , Geoffrey D. Hugo , Pamela Samson , Tianyu Zhao

Despite the progress made in the field of medical imaging, it remains a large area of open research, especially due to the variety of imaging modalities and disease-specific characteristics. This paper is a comparative study describing the…

Computer Vision and Pattern Recognition · Computer Science 2017-10-04 Meghana Dinesh Kumar , Morteza Babaie , Shujin Zhu , Shivam Kalra , H. R. Tizhoosh

The treatment planning process for patients with head and neck (H&N) cancer is regarded as one of the most complicated due to large target volume, multiple prescription dose levels, and many radiation-sensitive critical structures near the…

Medical Physics · Physics 2019-03-27 Dan Nguyen , Xun Jia , David Sher , Mu-Han Lin , Zohaib Iqbal , Hui Liu , Steve Jiang

Cold start knowledge base population (KBP) is the problem of populating a knowledge base from unstructured documents. While artificial neural networks have led to significant improvements in the different tasks that are part of KBP, the…

Information Retrieval · Computer Science 2020-08-20 Lingraj S Vannur , Balaji Ganesan , Lokesh Nagalapatti , Hima Patel , MN Thippeswamy