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The clinical adoption of artificial intelligence (AI) in medical diagnostics is critically hampered by its black-box nature, which prevents clinicians from verifying the rationale behind automated decisions. To overcome this fundamental…

Artificial intelligence has provided us with an exploration of a whole new research era. As more data and better computational power become available, the approach is being implemented in various fields. The demand for it in health…

Machine Learning · Computer Science 2020-08-11 Gloria Hyunjung Kwak , Pan Hui

In recent years, machine learning (ML) has become a key enabling technology for the sciences and industry. Especially through improvements in methodology, the availability of large databases and increased computational power, today's ML…

Artificial Intelligence · Computer Science 2019-09-27 Wojciech Samek , Klaus-Robert Müller

Machines are being increasingly used in decision-making processes, resulting in the realization that decisions need explanations. Unfortunately, an increasing number of these deployed models are of a 'black-box' nature where the reasoning…

Artificial Intelligence · Computer Science 2023-11-07 Sopam Dasgupta

Explaining deep learning models is essential for clinical integration of medical image analysis systems. A good explanation highlights if a model depends on spurious features that undermines generalization and harms a subset of patients or,…

Image and Video Processing · Electrical Eng. & Systems 2025-08-18 Yoni Schirris , Eric Marcus , Jonas Teuwen , Hugo Horlings , Efstratios Gavves

Artificial intelligence (AI) is rapidly advancing in healthcare, enhancing the efficiency and effectiveness of services across various specialties, including cardiology, ophthalmology, dermatology, emergency medicine, etc. AI applications…

Explainability has been an important goal since the early days of Artificial Intelligence. Several approaches for producing explanations have been developed. However, many of these approaches were tightly coupled with the capabilities of…

Artificial Intelligence · Computer Science 2020-03-20 Shruthi Chari , Daniel M. Gruen , Oshani Seneviratne , Deborah L. McGuinness

AI systems have seen significant adoption in various domains. At the same time, further adoption in some domains is hindered by inability to fully trust an AI system that it will not harm a human. Besides the concerns for fairness, privacy,…

Artificial Intelligence · Computer Science 2021-08-04 Amit Sheth , Manas Gaur , Kaushik Roy , Keyur Faldu

Computer-aided diagnosis (CAD), a vibrant medical imaging research field, is expanding quickly. Because errors in medical diagnostic systems might lead to seriously misleading medical treatments, major efforts have been made in recent years…

Machine Learning · Computer Science 2023-08-04 Farzaneh Tajidini , Mohammad-Javad Kheiri

Interest in the field of Explainable Artificial Intelligence has been growing for decades and has accelerated recently. As Artificial Intelligence models have become more complex, and often more opaque, with the incorporation of complex…

Artificial Intelligence · Computer Science 2020-03-18 Shruthi Chari , Daniel M. Gruen , Oshani Seneviratne , Deborah L. McGuinness

Artificial Intelligence (AI) has demonstrated potential in healthcare, particularly in enhancing diagnostic accuracy and decision-making through Clinical Decision Support Systems (CDSSs). However, the successful implementation of these…

Human-Computer Interaction · Computer Science 2025-01-29 Olya Rezaeian , Alparslan Emrah Bayrak , Onur Asan

Explainability is a critical factor in enhancing the trustworthiness and acceptance of artificial intelligence (AI) in healthcare, where decisions directly impact patient outcomes. Despite advancements in AI interpretability, clear…

Artificial Intelligence · Computer Science 2025-05-15 Michail Mamalakis , Héloïse de Vareilles , Graham Murray , Pietro Lio , John Suckling

Artificial Intelligence (AI) systems are increasingly deployed in legal contexts, where their opacity raises significant challenges for fairness, accountability, and trust. The so-called ``black box problem'' undermines the legitimacy of…

Artificial Intelligence · Computer Science 2025-10-14 Andrada Iulia Prajescu , Roberto Confalonieri

The increasing integration of artificial intelligence (AI) into medical diagnostics necessitates a critical examination of its ethical and practical implications. While the prioritization of diagnostic accuracy, as advocated by Sabuncu et…

Computers and Society · Computer Science 2025-01-16 Myles Joshua Toledo Tan , Panayiotis V. Benos

Healthcare systems around the world are grappling with issues like inefficient diagnostics, rising costs, and limited access to specialists. These problems often lead to delays in treatment and poor health outcomes. Most current AI and deep…

Artificial Intelligence · Computer Science 2025-12-22 Maliha Tabassum , M Shamim Kaiser

The discussions around Artificial Intelligence (AI) and medical imaging are centered around the success of deep learning algorithms. As new algorithms enter the market, it is important for practicing radiologists to understand the pitfalls…

Image and Video Processing · Electrical Eng. & Systems 2022-11-28 Rishi Gadepally , Andrew Gomella , Eric Gingold , Paras Lakhani

Interpretability, explainability and transparency are key issues to introducing Artificial Intelligence methods in many critical domains: This is important due to ethical concerns and trust issues strongly connected to reliability,…

Machine Learning · Computer Science 2023-01-25 George A. Vouros

Medical Image Analysis is currently experiencing a paradigm shift due to Deep Learning. This technology has recently attracted so much interest of the Medical Imaging community that it led to a specialized conference in `Medical Imaging…

Computer Vision and Pattern Recognition · Computer Science 2019-02-18 Fouzia Altaf , Syed M. S. Islam , Naveed Akhtar , Naeem K. Janjua

The ubiquity of systems using artificial intelligence or "AI" has brought increasing attention to how those systems should be regulated. The choice of how to regulate AI systems will require care. AI systems have the potential to synthesize…

Deep learning (DL) models have been popular due to their ability to learn directly from the raw data in an end-to-end paradigm, alleviating the concern of a separate error-prone feature extraction phase. Recent DL-based neuroimaging studies…

Machine Learning · Computer Science 2023-07-20 Md. Mahfuzur Rahman , Vince D. Calhoun , Sergey M. Plis