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Purpose: Computational head models are essential tools for studying the risk of mild traumatic brain injury (mTBI) under different activities and across populations. However, different computational models incorporate varied levels of…

Tissues and Organs · Quantitative Biology 2025-11-07 Anu Tripathi , Alison Brooks , Traci Snedden , Peter Ferrazzano , Christian Franck , Rika Wright Carlsen

This work considers electrical impedance tomography imaging of the human head, with the ultimate goal of locating and classifying a stroke in emergency care. One of the main difficulties in the envisioned application is that the electrode…

Numerical Analysis · Mathematics 2021-12-08 Valentina Candiani , Nuutti Hyvönen , Jari P. Kaipio , Ville Kolehmainen

Brain tissue accommodates non-linear deformations and exhibits time-dependent mechanical behaviour. The latter is one of the most pronounced features of brain tissue, manifesting itself primarily through viscoelastic effects such as stress…

Soft Condensed Matter · Physics 2025-12-23 G. Small , F. Ballatore , C. Giverso , V. Balbi

We use computational simulations to compare the impact response of different football and U.S. Army helmet pad materials. We conduct experiments to characterize the material response of different helmet pads. We simulate experimental helmet…

Medical Physics · Physics 2012-12-21 W. C. Moss , M. J. King , E. G. Blackman

Traumatic brain injuries (TBI) are considered a silent epidemic. It affects many people, from automobiles to sports to service members. In this study, we employed a musculoskeletal head-neck model to understand the effect of impact…

Tissues and Organs · Quantitative Biology 2024-12-09 Rahid Zaman , Ashfaq Adnan

The present endeavor numerically exploits the use of a phase-field model to simulate and investigate fracture patterns, deformation mechanisms, damage, and mechanical responses in a human vertebra after the incision of pedicle screws under…

Computational Engineering, Finance, and Science · Computer Science 2023-06-21 Deison Preve , Pietro Lenarda , Daniele Bianchi , Alessio Gizzi

For Huntington disease, identification of brain regions related to motor impairment can be useful for developing interventions to alleviate the motor symptom, the major symptom of the disease. However, the effects from the brain regions to…

Methodology · Statistics 2020-07-14 Rakheon Kim , Samuel Mueller , Tanya P. Garcia

Nonlinear evolution of shear waves into shocks in incompressible elastic materials is investigated using the framework of large deformation elastodynamics, for a family of loadings and commonly used hyperelastic material models. Closed form…

Soft Condensed Matter · Physics 2019-07-17 Chockalingam Senthilnathan , Tal Cohen

A simulation model for the spread and control of lesions in the brain is constructed using a planar network (graph) representation for the Central Nervous System (CNS). The model is inspired by the lesion structures observed in the case of…

Biological Physics · Physics 2007-08-27 T. R. Krishna Mohan

Computational biomechanics models of the brain have become an important tool for investigating the brain responses to mechanical loads. The geometry, loading conditions, and constitutive properties of such brain models are well-studied and…

Computational Engineering, Finance, and Science · Computer Science 2025-12-10 Sajjad Arzemanzadeh , Benjamin Zwick , Karol Miller , Tim Rosenow , Stuart I. Hodgetts , Adam Wittek

Plasticity is one of the most important properties of the nervous system, which enables animals to adjust their behavior to the ever-changing external environment. Changes in synaptic efficacy between neurons constitute one of the major…

Neurons and Cognition · Quantitative Biology 2018-01-23 Taishi Iwasaki , Hideitsu Hino , Masami Tatsuno , Shotaro Akaho , Noboru Murata

Many tasks in robot-assisted surgery require planning and controlling manipulators' motions that interact with highly deformable objects. This study proposes a realistic, time-bounded simulator based on Position-based Dynamics (PBD)…

Traumatic injuries are measured using the Abbreviated Injury Scale (AIS), which is a risk to life scale. New human computer models use stresses and strains to evaluate whether serious or fatal injuries are reached, unfortunately these…

Tissues and Organs · Quantitative Biology 2019-04-02 C. Bastien , C. Neal-Sturgess , J. Christensen , L. Wen

The formation of shear shock waves in the brain has been proposed as one of the plausible explanations for deep intracranial injuries. In fact, such singular solutions emerge naturally in soft viscoelastic tissues under dynamic loading…

Soft Condensed Matter · Physics 2025-02-05 Harold Berjamin

The brain-skull interface (meninges) plays a critical role in governing brain motion during head impacts, yet computational models often simplify this interface using idealized contact conditions due to limited experimental data. This study…

Computational Engineering, Finance, and Science · Computer Science 2025-12-10 Sajjad Arzemanzadeh , Karol Miller , Tim Rosenow , Sjoerd B. Vos , Adam Wittek

Mild traumatic brain injury (mTBI) often results from violent head motion or impact. Most prevention strategies explicitly or implicitly rely on motion- or deformation-based injury criteria, both of which require accurate measurements of…

Applied Physics · Physics 2025-08-12 Yang Wan , Benjamin E. Grossman-Ponemona , Haneesh Kesari

In the real world, the severity of traumatic injuries are measured using the Abbreviated Injury Scale (AIS). However the AIS scale cannot currently be computed by using finite element human computer models, which calculate a maximum…

Tissues and Organs · Quantitative Biology 2020-11-03 Christophe Bastien , Clive Neal-Sturgess , Huw Davies

Computer Tomography (CT) is the gold standard technique for brain damage evaluation after acute Traumatic Brain Injury (TBI). It allows identification of most lesion types and determines the need of surgical or alternative therapeutic…

Computer Vision and Pattern Recognition · Computer Science 2021-04-01 Ezequiel de la Rosa , Diana M. Sima , Thijs Vande Vyvere , Jan S. Kirschke , Bjoern Menze

Cerebrovascular accident (CVA) or stroke is the rapid loss of brain function due to disturbance in the blood supply to the brain. Statistically, stroke is the second leading cause of death. This has motivated us to suggest a two-tier system…

Machine Learning · Computer Science 2020-03-20 Jerrin Thomas Panachakel , Jeena R. S

A common shortcoming of vibration-based damage localization techniques is that localized damages, i.e. small cracks, have a limited influence on the spectral characteristics of a structure. In contrast, even the smallest of defects, under…

Computational Engineering, Finance, and Science · Computer Science 2023-05-23 Charilaos Mylonas , George Tsialiamanis , Keith Worden , Eleni N. Chatzi