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In both machine learning and in computational neuroscience, plasticity in functional neural networks is frequently expressed as gradient descent on a cost. Often, this imposes symmetry constraints that are difficult to reconcile with local…

Neurons and Cognition · Quantitative Biology 2026-04-09 Timo Gierlich , Andreas Baumbach , Akos F. Kungl , Kevin Max , Mihai A. Petrovici

The last decade has seen the parallel emergence in computational neuroscience and machine learning of neural network structures which spread the input signal randomly to a higher dimensional space; perform a nonlinear activation; and then…

Neural and Evolutionary Computing · Computer Science 2013-06-11 Jonathan Tapson , Andre van Schaik

In this work, we propose a generalized likelihood ratio method capable of training the artificial neural networks with some biological brain-like mechanisms,.e.g., (a) learning by the loss value, (b) learning via neurons with discontinuous…

Machine Learning · Computer Science 2019-07-12 Li Xiao , Yijie Peng , Jeff Hong , Zewu Ke , Shuhuai Yang

We propose a novel backpropagation algorithm for training spiking neural networks (SNNs) that encodes information in the relative multiple spike timing of individual neurons without single-spike restrictions. The proposed algorithm inherits…

Neural and Evolutionary Computing · Computer Science 2026-05-15 Kakei Yamamoto , Yusuke Sakemi , Kazuyuki Aihara

Recent research has shown the vulnerability of Spiking Neural Networks (SNNs) under adversarial examples that are nearly indistinguishable from clean data in the context of frame-based and event-based information. The majority of these…

Machine Learning · Computer Science 2025-09-01 Jiaqi Lin , Abhronil Sengupta

Spiking neural networks (SNNs) represent the most prominent biologically inspired computing model for neuromorphic computing (NC) architectures. However, due to the non-differentiable nature of spiking neuronal functions, the standard error…

Neural and Evolutionary Computing · Computer Science 2020-07-01 Jibin Wu , Yansong Chua , Malu Zhang , Guoqi Li , Haizhou Li , Kay Chen Tan

Backpropagation is the foundational algorithm for training neural networks and a key driver of deep learning's success. However, its biological plausibility has been challenged due to three primary limitations: weight symmetry, reliance on…

Neural and Evolutionary Computing · Computer Science 2025-06-05 Changze Lv , Jingwen Xu , Yiyang Lu , Xiaohua Wang , Zhenghua Wang , Zhibo Xu , Di Yu , Xin Du , Xiaoqing Zheng , Xuanjing Huang

The backpropagation of error algorithm (BP) is impossible to implement in a real brain. The recent success of deep networks in machine learning and AI, however, has inspired proposals for understanding how the brain might learn across…

Machine Learning · Computer Science 2018-11-21 Sergey Bartunov , Adam Santoro , Blake A. Richards , Luke Marris , Geoffrey E. Hinton , Timothy Lillicrap

The brain processes information through many layers of neurons. This deep architecture is representationally powerful, but it complicates learning by making it hard to identify the responsible neurons when a mistake is made. In machine…

Neurons and Cognition · Quantitative Biology 2014-11-04 Timothy P. Lillicrap , Daniel Cownden , Douglas B. Tweed , Colin J. Akerman

Efficient planning and sequence selection are central to intelligence, yet current approaches remain largely incompatible with biological computation. Classical graph algorithms like Dijkstra's or A* require global state and biologically…

Neural and Evolutionary Computing · Computer Science 2026-01-21 Simen Storesund , Kristian Valset Aars , Robin Dietrich , Nicolai Waniek

Stochastic gradient descent with backpropagation is the workhorse of artificial neural networks. It has long been recognized that backpropagation fails to be a biologically plausible algorithm. Fundamentally, it is a non-local procedure --…

Machine Learning · Statistics 2021-12-24 Ganlin Song , Ruitu Xu , John Lafferty

Compared with artificial neural networks (ANNs), spiking neural networks (SNNs) are promising to explore the brain-like behaviors since the spikes could encode more spatio-temporal information. Although pre-training from ANN or direct…

Neural and Evolutionary Computing · Computer Science 2018-09-18 Yujie Wu , Lei Deng , Guoqi Li , Jun Zhu , Luping Shi

Catastrophic forgetting has been the leading issue in the domain of lifelong learning in artificial systems. Current artificial systems are reasonably good at learning domains they have seen before; however, as soon as they encounter…

Machine Learning · Computer Science 2024-12-02 Ram Zaveri

Understanding how recurrent neural circuits can learn to implement dynamical systems is a fundamental challenge in neuroscience. The credit assignment problem, i.e. determining the local contribution of each synapse to the network's global…

Neurons and Cognition · Quantitative Biology 2017-08-08 Alireza Alemi , Christian Machens , Sophie Denève , Jean-Jacques Slotine

Despite the recent success of artificial neural networks, more biologically plausible learning methods may be needed to resolve the weaknesses of backpropagation trained models such as catastrophic forgetting and adversarial attacks.…

Machine Learning · Computer Science 2022-08-09 Ole Christian Eidheim

The spectacular results achieved in machine learning, including the recent advances in generative AI, rely on large data collections. On the opposite, intelligent processes in nature arises without the need for such collections, but simply…

Machine Learning · Computer Science 2024-02-12 Alessandro Betti , Marco Gori

Spiking neural networks (SNNs) have superb characteristics in sensory information recognition tasks due to their biological plausibility. However, the performance of some current spiking-based models is limited by their structures which…

Neural and Evolutionary Computing · Computer Science 2023-04-20 Qi Xu , Yaxin Li , Xuanye Fang , Jiangrong Shen , Jian K. Liu , Huajin Tang , Gang Pan

Large multilayer neural networks trained with backpropagation have recently achieved state-of-the-art results in a wide range of problems. However, using backprop for neural net learning still has some disadvantages, e.g., having to tune a…

Machine Learning · Statistics 2015-07-16 José Miguel Hernández-Lobato , Ryan P. Adams

While deep neural networks (DNNs) have achieved remarkable performance in tasks such as image recognition, they often struggle with generalization, learning from few examples, and continuous adaptation - abilities inherent in biological…

Machine Learning · Computer Science 2026-03-04 Patrick Inoue , Florian Röhrbein , Andreas Knoblauch

The ubiquitous backpropagation algorithm requires sequential updates through the network introducing a locking problem. In addition, back-propagation relies on the transpose of forward weight matrices to compute updates, introducing a…

Machine Learning · Computer Science 2023-10-31 David Kappel , Khaleelulla Khan Nazeer , Cabrel Teguemne Fokam , Christian Mayr , Anand Subramoney