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Meta-analyses are commonly performed based on random-effects models, while in certain cases one might also argue in favour of a common-effect model. One such case may be given by the example of two "study twins" that are performed according…

Methodology · Statistics 2024-09-04 Christian Röver , Tim Friede

The identification of causal effects in observational studies typically relies on two standard assumptions: unconfoundedness and overlap. However, both assumptions are often questionable in practice: unconfoundedness is inherently…

Methodology · Statistics 2025-09-17 Han Cui , Xinran Li

Single-arm studies in the early development phases of new treatments are not uncommon in the context of rare diseases or in paediatrics. If an assessment of efficacy is to be made at the end of such a study, the observed endpoints can be…

Methodology · Statistics 2026-03-02 Moritz Fabian Danzer , Rene Schmidt

In this paper, we propose a new modified likelihood ratio test (LRT) for simultaneously testing mean vectors and covariance matrices of two-sample populations in high-dimensional settings. By employing tools from Random Matrix Theory (RMT),…

Applications · Statistics 2024-03-12 Zhenzhen Niu , Jianghao Li , Wenya Luo , Zhidong Bai

Meta-regression is often used to form hypotheses about what is associated with heterogeneity in a meta-analysis and to estimate the extent to which effects can vary between cohorts and other distinguishing factors. However, study-level…

Methodology · Statistics 2021-11-19 Maxwell Cairns , Luke A. Prendergast

When randomized ensemble methods such as bagging and random forests are implemented, a basic question arises: Is the ensemble large enough? In particular, the practitioner desires a rigorous guarantee that a given ensemble will perform…

Machine Learning · Statistics 2019-08-06 Miles E. Lopes , Suofei Wu , Thomas C. M. Lee

Cochran's $Q$ statistic is routinely used for testing heterogeneity in meta-analysis. Its expected value is also used for estimation of between-study variance $\tau^2$. Cochran's $Q$, or $Q_{IV}$, uses estimated inverse-variance weights…

Methodology · Statistics 2021-03-08 Ilyas Bakbergenuly , David C. Hoaglin , Elena Kulinskaya

Diagnostic accuracy studies assess sensitivity and specificity of a new index test in relation to an established comparator or the reference standard. The development and selection of the index test is usually assumed to be conducted prior…

Methodology · Statistics 2022-08-30 Max Westphal , Antonia Zapf

By amalgamating data from disparate sources, the resulting integrated dataset becomes a valuable resource for statistical analysis. In probabilistic record linkage, the effectiveness of such integration relies on the availability of linkage…

Methodology · Statistics 2025-11-10 Siu-Ming Tam , Min Wang , Alicia Rambaldi , Dehua Tao

The use of longitudinal finite mixture models such as group-based trajectory modeling has seen a sharp increase during the last decades in the medical literature. However, these methods have been criticized especially because of the…

Methodology · Statistics 2022-05-17 Miceline Mésidor , Caroline Sirois , Marc Simard , Denis Talbot

Standardization has been a widely adopted practice in multiple testing, for it takes into account the variability in sampling and makes the test statistics comparable across different study units. However, despite conventional wisdom to the…

Methodology · Statistics 2020-03-09 Luella Fu , Bowen Gang , Gareth M. James , Wenguang Sun

This paper proposes a new non-parametric bootstrap method to quantify the uncertainty of average treatment effect estimate for the treated from matching estimators. More specifically, it seeks to quantify the uncertainty associated with the…

Methodology · Statistics 2024-08-21 Jing Li

Modern problems in statistics tend to include estimators of high computational complexity and with complicated distributions. Statistical inference on such estimators usually relies on asymptotic normality assumptions, however, such…

Methodology · Statistics 2016-12-08 Eyal Fisher , Regev Schweiger , Saharon Rosset

Finite mixtures of multivariate normal distributions have been widely used in empirical applications in diverse fields such as statistical genetics and statistical finance. Testing the number of components in multivariate normal mixture…

Statistics Theory · Mathematics 2019-02-11 Hiroyuki Kasahara , Katsumi Shimotsu

This paper provides general expression for Bartlett and Bartlett-type correction factors for the likelihood ratio and gradient statistics to test the dispersion parameter in heteroscedastic symmetric nonlinear models. This class of…

Statistics Theory · Mathematics 2020-04-24 Mariana C. Araújo , Audrey H. M. A. Cysneiros , Lourdes C. Montenegro

Large-Language Models (LLMs) have shifted the paradigm of natural language data processing. However, their black-boxed and probabilistic characteristics can lead to potential risks in the quality of outputs in diverse LLM applications.…

Software Engineering · Computer Science 2023-12-12 Sangwon Hyun , Mingyu Guo , M. Ali Babar

The paper proposes a new bootstrap approach to the Pesaran, Shin and Smith's bound tests in a conditional equilibrium correction model with the aim to overcome some typical drawbacks of the latter, such as inconclusive inference and…

Econometrics · Economics 2022-04-12 Stefano Bertelli , Gianmarco Vacca , Maria Grazia Zoia

This paper proposes a new test for the comparison of conditional quantile curves when the outcome of interest, typically a duration, is subject to right censoring. The test can be applied both in the case of two independent samples and for…

Methodology · Statistics 2023-02-08 Lorenzo Tedesco , Ingrid Van Keilegom

This paper introduces a likelihood ratio (LR)-type test that possesses the robustness properties of \(C(\alpha)\)-type procedures in an extremum estimation setting. The test statistic is constructed by applying separate adjustments to the…

Econometrics · Economics 2025-10-21 Jean-Marie Dufour , Purevdorj Tuvaandorj

Retrieval-augmented Generation (RAG) has demonstrated potential in enhancing medical question-answering systems through the integration of large language models (LLMs) with external medical literature. LLMs can retrieve relevant medical…

Computation and Language · Computer Science 2025-10-29 Mengzhou Sun , Sendong Zhao , Jianyu Chen , Haochun Wang , Bin Qin