English

Simulation study of Q statistic with constant weights for testing and estimation of heterogeneity of standardized mean differences in meta-analysis

Methodology 2021-03-08 v1

Abstract

Cochran's QQ statistic is routinely used for testing heterogeneity in meta-analysis. Its expected value is also used for estimation of between-study variance τ2\tau^2. Cochran's QQ, or QIVQ_{IV}, uses estimated inverse-variance weights which makes approximating its distribution rather complicated. As an alternative, we are investigating a new QQ statistic, QFQ_F, whose constant weights use only the studies' effective sample sizes. For standardized mean difference as the measure of effect, we study, by simulation, approximations to distributions of QIVQ_{IV} and QFQ_F, as the basis for tests of heterogeneity and for new point and interval estimators of the between-study variance τ2\tau^2. These include new DerSimonian-Kacker (2007)-type moment estimators based on the first moment of QFQ_F, and novel median-unbiased estimators of τ2\tau^2.

Keywords

Cite

@article{arxiv.2103.03272,
  title  = {Simulation study of Q statistic with constant weights for testing and estimation of heterogeneity of standardized mean differences in meta-analysis},
  author = {Ilyas Bakbergenuly and David C. Hoaglin and Elena Kulinskaya},
  journal= {arXiv preprint arXiv:2103.03272},
  year   = {2021}
}