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Causal discovery from observational and interventional data is challenging due to limited data and non-identifiability: factors that introduce uncertainty in estimating the underlying structural causal model (SCM). Selecting experiments…

Machine Learning · Computer Science 2022-10-24 Panagiotis Tigas , Yashas Annadani , Andrew Jesson , Bernhard Schölkopf , Yarin Gal , Stefan Bauer

Causal discovery algorithms estimate causal graphs from observational data. This can provide a valuable complement to analyses focussing on the causal relation between individual treatment-outcome pairs. Constraint-based causal discovery…

Methodology · Statistics 2021-08-31 Janine Witte , Ronja Foraita , Vanessa Didelez

Causal models seek to unravel the cause-effect relationships among variables from observed data, as opposed to mere mappings among them, as traditional regression models do. This paper introduces a novel causal discovery algorithm designed…

Machine Learning · Computer Science 2024-10-03 Saeed Mohseni-Sehdeh , Walid Saad

Causal analysis helps us understand variables that are responsible for system failures. This improves fault detection and makes system more reliable. In this work, we present a new method that combines causal inference with machine learning…

Systems and Control · Electrical Eng. & Systems 2025-08-05 Karthik Peddi , Sai Ram Aditya Parisineni , Hemanth Macharla , Mayukha Pal

Causal Structure Learning (CSL), also referred to as causal discovery, amounts to extracting causal relations among variables in data. CSL enables the estimation of causal effects from observational data alone, avoiding the need to perform…

Machine Learning · Computer Science 2025-02-12 Fabrizio Russo , Francesca Toni

Electronic Health Records (EHRs) contain rich, longitudinal patient information across structured (e.g., labs, vitals, and imaging) and unstructured (e.g., clinical notes) modalities. While deep learning models such as RNNs and Transformers…

Machine Learning · Computer Science 2026-02-18 Mohammad Al Olaimat , Shaika Chowdhury , Serdar Bozdag

Nonlinear causal discovery from observational data imposes strict identifiability assumptions on the formulation of structural equations utilized in the data generating process. The evaluation of structure learning methods under assumption…

Machine Learning · Statistics 2024-12-17 Georg Velev , Stefan Lessmann

Predicting disease trajectories from electronic health records (EHRs) is a complex task due to major challenges such as data non-stationarity, high granularity of medical codes, and integration of multimodal data. EHRs contain both…

Machine Learning · Computer Science 2025-02-26 Sifal Klioui , Sana Sellami , Youssef Trardi

Learning causal structure from observational data is a fundamental challenge in machine learning. However, the majority of commonly used differentiable causal discovery methods are non-identifiable, turning this problem into a continuous…

Machine Learning · Computer Science 2022-09-30 Yu Wang , An Zhang , Xiang Wang , Yancheng Yuan , Xiangnan He , Tat-Seng Chua

Discovering causal structures with latent variables from observational data is a fundamental challenge in causal discovery. Existing methods often rely on constraint-based, iterative discrete searches, limiting their scalability to large…

Machine Learning · Computer Science 2024-12-02 Parjanya Prashant , Ignavier Ng , Kun Zhang , Biwei Huang

Going beyond correlations, the understanding and identification of causal relationships in observational time series, an important subfield of Causal Discovery, poses a major challenge. The lack of access to a well-defined ground truth for…

Machine Learning · Statistics 2021-04-19 Andrew R. Lawrence , Marcus Kaiser , Rui Sampaio , Maksim Sipos

Randomized controlled trials (RCTs) are the standard for evaluating the effectiveness of clinical interventions. To address the limitations of RCTs on real-world populations, we developed a methodology that uses a large observational…

Machine Learning · Computer Science 2024-10-21 Panayiotis Petousis , David Gordon , Susanne B. Nicholas , Alex A. T. Bui

The growing availability of observational databases like electronic health records (EHR) provides unprecedented opportunities for secondary use of such data in biomedical research. However, these data can be error-prone and need to be…

Methodology · Statistics 2024-05-28 Sarah C. Lotspeich , Gustavo G. C. Amorim , Pamela A. Shaw , Ran Tao , Bryan E. Shepherd

Using observational data to learn causal relationships is essential when randomized experiments are not possible, such as in healthcare. Discovering causal relationships in time-series health data is even more challenging when relationships…

Artificial Intelligence · Computer Science 2023-05-08 Bharat Srikishan , Samantha Kleinberg

Type 2 diabetes (T2DM), one of the most prevalent chronic diseases, affects the glucose metabolism of the human body, which decreases the quantity of life and brings a heavy burden on social medical care. Patients with T2DM are more likely…

Quantitative Methods · Quantitative Biology 2020-07-01 Wei Wang , Gangqiang Hu , Bo Yuan , Shandong Ye , Chao Chen , YaYun Cui , Xi Zhang , Liting Qian

Biosensor data has the potential ability to improve disease control and detection. However, the analysis of these data under free-living conditions is not feasible with current statistical techniques. To address this challenge, we introduce…

Applications · Statistics 2021-03-30 Marcos Matabuena , Alexander Petersen , Juan C. Vidal , Francisco Gude

We present a workflow for clinical data analysis that relies on Bayesian Structure Learning (BSL), an unsupervised learning approach, robust to noise and biases, that allows to incorporate prior medical knowledge into the learning process…

Machine Learning · Computer Science 2022-10-12 Elisa Ferrari , Luna Gargani , Greta Barbieri , Lorenzo Ghiadoni , Francesco Faita , Davide Bacciu

Type 2 diabetes mellitus (T2DM) is one of the most common diseases and a leading cause of death. The problem of early diagnosis of T2DM is challenging and necessary to prevent serious complications. This study proposes a novel neural…

Machine Learning · Computer Science 2023-01-20 Tayyab Nasir , Muhammad Kamran Malik

This paper focuses on causal structure estimation from time series data in which measurements are obtained at a coarser timescale than the causal timescale of the underlying system. Previous work has shown that such subsampling can lead to…

Artificial Intelligence · Computer Science 2016-07-14 Antti Hyttinen , Sergey Plis , Matti Järvisalo , Frederick Eberhardt , David Danks
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