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Understanding the factors that trigger or prevent undesirable health outcomes across patient subpopulations is essential for designing targeted interventions. While randomized controlled trials and expert-led patient interviews are standard…

Artificial Intelligence · Computer Science 2026-05-28 Shishir Adhikari , Guido Muscioni , Mark Shapiro , Plamen Petrov , Elena Zheleva

In the healthcare sector, the application of deep learning technologies has revolutionized data analysis and disease forecasting. This is particularly evident in the field of diabetes, where the deep analysis of Electronic Health Records…

Machine Learning · Computer Science 2024-12-06 Huadong Pang , Li Zhou , Yiping Dong , Peiyuan Chen , Dian Gu , Tianyi Lyu , Hansong Zhang

Time series data are found in many areas of healthcare such as medical time series, electronic health records (EHR), measurements of vitals, and wearable devices. Causal discovery, which involves estimating causal relationships from…

Machine Learning · Computer Science 2023-10-18 Muhammad Hasan Ferdous , Uzma Hasan , Md Osman Gani

Electronic healthcare records (EHR) contain a huge wealth of data that can support the prediction of clinical outcomes. EHR data is often stored and analysed using clinical codes (ICD10, SNOMED), however these can differ across registries…

Machine Learning · Computer Science 2024-12-03 Elizabeth Remfry , Rafael Henkin , Michael R Barnes , Aakanksha Naik

Diabetes, a pervasive and enduring health challenge, imposes significant global implications on health, financial healthcare systems, and societal well-being. This study undertakes a comprehensive exploration of various structural learning…

Machine Learning · Computer Science 2024-03-22 Sheresh Zahoor , Anthony C. Constantinou , Tim M Curtis , Mohammed Hasanuzzaman

The ability to understand causality from data is one of the major milestones of human-level intelligence. Causal Discovery (CD) algorithms can identify the cause-effect relationships among the variables of a system from related…

Artificial Intelligence · Computer Science 2024-03-14 Uzma Hasan , Emam Hossain , Md Osman Gani

It is commonplace to encounter heterogeneous or nonstationary data, of which the underlying generating process changes across domains or over time. Such a distribution shift feature presents both challenges and opportunities for causal…

Machine Learning · Computer Science 2020-06-26 Biwei Huang , Kun Zhang , Jiji Zhang , Joseph Ramsey , Ruben Sanchez-Romero , Clark Glymour , Bernhard Schölkopf

Causal modeling has long been an attractive topic for many researchers and in recent decades there has seen a surge in theoretical development and discovery algorithms. Generally discovery algorithms can be divided into two approaches:…

Machine Learning · Statistics 2017-02-06 Ridho Rahmadi , Perry Groot , Marianne Heins , Hans Knoop , Tom Heskes

Objectives: In the United States, 25% of people with type 2 diabetes are undiagnosed. Conventional screening models use limited demographic information to assess risk. We evaluated whether electronic health record (EHR) phenotyping could…

Quantitative Methods · Quantitative Biology 2015-01-13 Ariana E. Anderson , Wesley T. Kerr , April Thames , Tong Li , Jiayang Xiao , Mark S. Cohen

Methods of causal discovery aim to identify causal structures in a data driven way. Existing algorithms are known to be unstable and sensitive to statistical errors, and are therefore rarely used with biomedical or epidemiological data. We…

Methodology · Statistics 2024-07-01 Christine W Bang , Janine Witte , Ronja Foraita , Vanessa Didelez

The increase in availability of longitudinal electronic health record (EHR) data is leading to improved understanding of diseases and discovery of novel phenotypes. The majority of clustering algorithms focus only on patient trajectories,…

Machine Learning · Computer Science 2021-11-12 Oliver Carr , Avelino Javer , Patrick Rockenschaub , Owen Parsons , Robert Dürichen

Causal discovery aims to infer causal relationships among variables from observational data, typically represented by a directed acyclic graph (DAG). Most existing methods assume independent and identically distributed observations, an…

Methodology · Statistics 2026-03-27 Alex Chen , Qing Zhou

Missingness in variables that define study eligibility criteria is a seldom addressed challenge in electronic health record (EHR)-based settings. It is typically the case that patients with incomplete eligibility information are excluded…

This study proposes Evolutionary Causal Discovery (ECD) for causal discovery that tailors response variables, predictor variables, and corresponding operators to research datasets. Utilizing genetic programming for variable relationship…

Machine Learning · Computer Science 2024-04-26 Ou Deng , Shoji Nishimura , Atsushi Ogihara , Qun Jin

Constraint-based methods and noise-based methods are two distinct families of methods proposed for uncovering causal graphs from observational data. However, both operate under strong assumptions that may be challenging to validate or could…

Artificial Intelligence · Computer Science 2024-05-01 Daria Bystrova , Charles K. Assaad , Julyan Arbel , Emilie Devijver , Eric Gaussier , Wilfried Thuiller

The importance of clinical variables in the prognosis of the disease is explained using statistical correlation or machine learning (ML). However, the predictive importance of these variables may not represent their causal relationships…

Machine Learning · Statistics 2025-06-04 Yina Hou , Shourav B. Rabbani , Liang Hong , Norou Diawara , Manar D. Samad

The use of Electronic Health Records (EHRs) has increased dramatically in the past 15 years, as, it is considered an important source of managing data od patients. The EHRs are primary sources of disease diagnosis and demographic data of…

Machine Learning · Computer Science 2024-04-02 Bushra F. Alsaqer , Alaa F. Alsaqer , Amna Asif

Electronic Health Records (EHR) data analysis plays a crucial role in healthcare system quality. Because of its highly complex underlying causality and limited observable nature, causal inference on EHR is quite challenging. Deep Learning…

Machine Learning · Computer Science 2022-10-28 Jia Li , Haoyu Yang , Xiaowei Jia , Vipin Kumar , Michael Steinbach , Gyorgy Simon

Increasingly large electronic health records (EHRs) provide an opportunity to algorithmically learn medical knowledge. In one prominent example, a causal health knowledge graph could learn relationships between diseases and symptoms and…

Applications · Statistics 2019-10-04 Irene Y. Chen , Monica Agrawal , Steven Horng , David Sontag

Causal inference methods for observational data are increasingly recognized as a valuable complement to randomized clinical trials (RCTs). They can, under strong assumptions, emulate RCTs or help refine their focus. Our approach to causal…

Methodology · Statistics 2024-08-14 Carlo Berzuini , Davide Luciani , Hiren C. Patel
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