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The COVID-19 pandemic has severely impacted health systems and economies worldwide. Significant global efforts are therefore ongoing to improve vaccine efficacies, optimize vaccine deployment, and develop new antiviral therapies to combat…

Populations and Evolution · Quantitative Biology 2021-12-21 Rajat Desikan , Pranesh Padmanabhan , Andrzej M. Kierzek , Piet H. van der Graaf

This paper proposes a hypothetical model for the dual role of respiratory aerosols and inflammatory exudates in the dynamics and progression of SARS-CoV-2 lung infection. Starting from a new paradigm in infectious disease transmission, we…

Tissues and Organs · Quantitative Biology 2025-06-02 Shi Qiru

The SARS-CoV-2 virus is primarily transmitted through virus-laden fluid particles ejected from the mouth of infected people. Face covers can mitigate the risk of virus transmission but their outward effectiveness is not fully ascertained.…

The dense social contact networks and high mobility in congested urban areas facilitate the rapid transmission of infectious diseases. Typical mechanistic epidemiological models are either based on uniform mixing with ad-hoc contact…

Physics and Society · Physics 2020-09-28 Rohan Patil , Raviraj Dave , Harsh Patel , Viraj M Shah , Deep Chakrabarti , Udit Bhatia

Coronavirus Disease 2019 (COVID-19) is a rapidly emerging respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Due to the rapid human-to-human transmission of SARS-CoV-2, many healthcare systems…

Machine Learning · Computer Science 2020-12-01 Patrick Schwab , August DuMont Schütte , Benedikt Dietz , Stefan Bauer

The rapid spreading of SARS-CoV-2 and its dramatic consequences, are forcing policymakers to take strict measures in order to keep the population safe. At the same time, societal and economical interactions are to be safeguarded. A wide…

Disordered Systems and Neural Networks · Physics 2021-02-17 Lorenzo Chicchi , Lorenzo Giambagli , Lorenzo Buffoni , Duccio Fanelli

In this paper, we present a method to forecast the spread of SARS-CoV-2 across regions with a focus on the role of mobility. Mobility has previously been shown to play a significant role in the spread of the virus, particularly between…

Optimization and Control · Mathematics 2023-02-28 Martijn H. H. Schoot Uiterkamp , Martijn Gösgens , Hans Heesterbeek , Remco van der Hofstad , Nelly Litvak

The mechanism of SARS-CoV-2 evolution and transmission is elusive and its understanding, a prerequisite to forecast emerging variants, is of paramount importance. SARS-CoV-2 evolution is driven by the mechanisms at molecular and organism…

Populations and Evolution · Quantitative Biology 2021-09-20 Jiahui Chen , Rui Wang , Guo-Wei Wei

The world is suffering from a pandemic called COVID-19, caused by the SARS-CoV-2 virus. National governments have problems evaluating the reach of the epidemic, due to having limited resources and tests at their disposal. This problem is…

Besides mimicking bio-chemical and multi-scale communication mechanisms, molecular communication forms a theoretical framework for virus infection processes. Towards this goal, aerosol and droplet transmission has recently been modeled as a…

Information Theory · Computer Science 2021-01-29 Peter Adam Hoeher , Martin Damrath , Sunasheer Bhattacharjee , Max Schurwanz

As of December 2020, the COVID-19 pandemic has infected over 75 million people, making it the deadliest pandemic in modern history. This study develops a novel compartmental epidemiological model specific to the SARS-CoV-2 virus and…

Populations and Evolution · Quantitative Biology 2021-11-19 Caden Lin

Rapid testing is essential to fighting pandemics such as COVID-19, the disease caused by the SARS-CoV-2 virus. Exhaled human breath contains multiple volatile molecules providing powerful potential for non-invasive diagnosis of diverse…

While many epidemiological models have being proposed to understand and handle COVID-19, too little has been invested to understand how the virus replicates in the human body and potential antiviral can be used to control the replication…

Characterising drivers of SARS-CoV-2 circulation is crucial for understanding COVID-19 because of the severity of control measures adopted during the pandemic. Whole genome sequence data augmented with demographic metadata provides the best…

Populations and Evolution · Quantitative Biology 2024-09-17 Anna Gamża , Samantha Lycett , Will Harvey , Joseph Hughes , Sema Nickbakhsh , David L Robertson , Alison Smith Palmer , Anthony Wood , Rowland Kao

At the time of writing, the ongoing COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), had already resulted in more than thirty-two million cases infected and more than one million deaths worldwide.…

Optimization and Control · Mathematics 2023-03-22 Chung-Han Hsieh

Originating in Wuhan, the novel coronavirus, severe acute respiratory syndrome 2 (SARS-CoV-2), has astonished health-care systems across globe due to its rapid and simultaneous spread to the neighboring and distantly located countries. To…

Populations and Evolution · Quantitative Biology 2020-06-30 Vikram Singh , Vikram Singh

In light of the continuing emergence of new SARS-CoV-2 variants and vaccines, we create a simulation framework for exploring possible infection trajectories under various scenarios. The situations of primary interest involve the interaction…

Populations and Evolution · Quantitative Biology 2022-01-10 Kory D. Johnson , Annemarie Grass , Daniel Toneian , Mathias Beiglböck , Jitka Polechová

We investigate transmission dynamics for SARS-CoV-2 on a real network of classes at Simon Fraser University, a medium-sized school in Western Canada. Outbreaks are simulated over the course of one semester across numerous parameter settings…

Applications · Statistics 2022-06-02 William Ruth , Richard Lockhart

Mechanistic models fit to streaming surveillance data are critical to understanding the transmission dynamics of an outbreak as it unfolds in real-time. However, transmission model parameter estimation can be imprecise, and sometimes even…

A comprehensive retrospective analysis of public health interventions, such as large scale testing, quarantining, and contact tracing, can help identify mechanisms most effective in mitigating COVID-19. We investigate China based SARS-CoV-2…

Machine Learning · Computer Science 2025-12-30 Zhou Yang , Edward Dougherty , Chen Zhang , Zhenhe Pan , Fang Jin
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