Related papers: Elastocapillary network model of inhalation
We propose a multi-scale lung model to investigate spatio-temporal distributions of ventilation variables. Lung envelope and large airway geometries are derived from CT scans; smaller airways are generated using a physiologically consistent…
The airflow in a subject-specific breathing human lung is simulated with a multiscale computational fluid dynamics (CFD) lung model. The three-dimensional (3D) airway geometry beginning from the mouth to about 7 generations of airways is…
Here we develop a lung ventilation model, based a continuum poroelastic representation of lung parenchyma and a 0D airway tree flow model. For the poroelastic approximation we design and implement a lowest order stabilised finite element…
We present a new approach for physics-based computational modeling of diseased human lungs. Our main object is the development of a model that takes the novel step of incorporating the dynamics of airway recruitment/de-recruitment into an…
The air flows in the proximal and distal portions of the human lungs are interconnected: the lower Reynolds number in the deeper generations causes a progressive flow regularization, while mass conservation requires flow rate oscillations…
Human breath contains a myriad of endogenous volatile organic compounds (VOCs) which are reflective of ongoing metabolic or physiological processes. While research into the diagnostic potential and general medical relevance of these trace…
The aerosol formation is associated with the rupture of the liquid plug during the pulmonary airway reopening. The fluid dynamics of this process is difficult to predict because the rupture involved complex liquid-gas transition. Equation…
The flow simulation in alveolar region is imperative in understanding transport of particles and designing aerosol drug delivery systems. Air flow is dependent on alveolar geometry and ventilation conditions. In this work a three…
We study a statistical mechanical model for the dynamics of lung inflation which incorporates recent experimental observations on the opening of individual airways by a cascade or avalanche mechanism. Using an exact mapping of the avalanche…
Chest physiotherapy is an empirical technique used to help secretions to get out of the lung whenever stagnation occurs. Although commonly used, little is known about the inner mechanisms of chest physiotherapy and controversies about its…
Airway mucus is a complex material with both viscoelastic and viscoplastic properties that vary with healthy and pathological lung conditions. In this study, the effects of these conditions on airway closure are examined in a model problem,…
Many organisms have an elastic skeleton that consists of a closed shell of epithelial cells that is filled with fluid, and can actively regulate both elastic forces in the shell and hydrostatic pressure inside it. In this work we introduce…
We investigate analytically the production of entropy during a breathing cycle in healthy and diseased lungs. First, we calculate entropy production in healthy lungs by applying the laws of thermodynamics to the well-known transpulmonary…
Frequently during its lifetime a human organism is subjected to the acoustical and similar to them vibrating impacts. Under the certain conditions such influence may cause physiological changes in the organs functioning. Thus the study of…
We employ a novel computational modeling framework to perform high-fidelity direct numerical simulations of aero-structural interactions in bat-inspired membrane wings. The wing of a bat consists of an elastic membrane supported by a highly…
This paper presents a recurrent neural network approach to simulating mechanical ventilator pressure. The traditional mechanical ventilator has a control pressure that is monitored by a medical practitioner and can behave incorrectly if the…
Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung disease characterized by airflow limitation. This study develops a systems engineering framework for representing important mechanistic details of COPD in a model of the…
The space-time dynamics of rigid inhomogeneities (inclusions) free to move in a randomly fluctuating fluid bio-membrane is derived and numerically simulated as a function of the membrane shape changes. Both vertically placed (embedded)…
The airflow in the bronchi applies a shear stress on the bronchial mucus, which can move the mucus. The air--mucus interaction plays an important role in cough and in chest physiotherapy (CP). The conditions under which it induces a…
Non-invasive ventilation is increasingly used for respiratory support in preterm infants, and is associated with a lower risk of chronic lung disease. However, this mode is often not successful in the extremely preterm infant in part due to…