Related papers: Elastocapillary network model of inhalation
In this work we present a mathematical framework that quantifies the gas-exchange processes in the lung. The theory is based on the solution of the one-dimensional diffusion equation on a simplified model of lung septum. Gases dissolved…
Vascular networks exhibit a remarkable diversity of architectures and transport mechanisms across biological systems. Inspired by embolism propagation in plant xylem, where air invades water-filled conduits under negative pressure, we study…
Mitochondrial networks exhibit a variety of complex behaviors, including coordinated cell-wide oscillations of energy states as well as a phase transition (depolarization) in response to oxidative stress. Since functional and structural…
Investigations on airborne transmission of pathogens constitute a rapidly expanding field, primarily focused on understanding the expulsion patterns of respiratory particulates from infected hosts and their dispersion in confined spaces.…
This study uses a one dimensional fluid dynamics arterial network model to infer changes in hemodynamic quantities associated with pulmonary hypertension in mice. Data for this study include blood flow and pressure measurements from the…
Chest physiotherapy is a set of techniques used to help the draining of the mucus from the lung in pathological situations. The choice of the techniques, and their adjustment to the patients or to the pathologies, remains as of today…
The behaviour of elastic structures undergoing large deformations is the result of the competition between confining conditions, self-avoidance and elasticity. This combination of multiple phenomena creates a geometrical frustration that…
Cells and tissues change shape both to carry out their function and during pathology. In most cases, these deformations are driven from within the systems themselves. This is permitted by a range of molecular actors, such as active…
This paper proposes a hypothetical model for the dual role of respiratory aerosols and inflammatory exudates in the dynamics and progression of SARS-CoV-2 lung infection. Starting from a new paradigm in infectious disease transmission, we…
Patients with epilepsy can manifest short, sub-clinical epileptic "bursts" in addition to full-blown clinical seizures. We believe the relationship between these two classes of events---something not previously studied…
In this paper, a 3D discrete model is presented to model the movements of the trunk during breathing. In this model, objects are represented by physical particles on their contours. A simple notion of force generated by a linear actuator…
Wrinkling of an inextensible elastic lining of an inner-lined tube under imposed pressure is considered. A simple equation modeling the elastic properties of the lining, the pressure, and the soft-substrate forces is derived. This equation…
The shapes of epithelial tissues result from a complex interplay of contractile forces in the cytoskeleta of the cells in the tissue, and adhesion forces between them. A host of discrete, cell-based models describe these forces by assigning…
Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering,…
Inhalation directs air through a defined pathway, initiating from nostrils, moving through the main nasal cavity, past the pharynx and trachea, and culminating in the lungs. Inhaled particles, of a range of sizes, are ferried by this…
Arterial biomechanical indicators have long been recognized as fundamental contributors to the physiology and pathology of cardiovascular systems. Probing the multiple biomechanical parameters of arteries simultaneously at different time…
A mean-field kinetic model suggests that the relaxation dynamics of wormlike micellar networks is a long and complex process due to the problem of reducing the number of free end-caps (or dangling ends) while also reaching an equilibrium…
Could the microdroplets formed by viscoelastic stretching and break-up of mucosal liquids in the upper respiratory tract (URT), when inhaled further downwind, explain the brisk pace at which deep lung infections emerge following onset of…
Chronic respiratory diseases, such as chronic obstructive pulmonary disease and asthma, are a serious health crisis, affecting a large number of people globally and inflicting major costs on the economy. Current methods for assessing the…
The study reported herein attempts to understand the neural mechanisms engaged in the conscious control of breathing and breath-hold. The variations in the electroencephalogram (EEG) based functional connectivity (FC) of the human brain…