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Although the latest advances in MRI technology have allowed the acquisition of higher resolution images, reliable delineation of cytoarchitectural or subcortical nuclei boundaries is not possible. As a result, histological images are still…

In this paper, we describe the optical imaging data processing pipeline developed for the Subaru Telescope's Hyper Suprime-Cam (HSC) instrument. The HSC Pipeline builds on the prototype pipeline being developed by the Large Synoptic Survey…

Although deep encoder-decoder networks have achieved astonishing performance for mitochondria segmentation from electron microscopy (EM) images, they still produce coarse segmentations with lots of discontinuities and false positives.…

Computer Vision and Pattern Recognition · Computer Science 2020-01-30 Zhimin Yuan , Jiajin Yi , Zhengrong Luo , Zhongdao Jia , Jialin Peng

Electron microscopy (EM) imaging offers unparalleled resolution for analyzing neural tissues, crucial for uncovering the intricacies of synaptic connections and neural processes fundamental to understanding behavioral mechanisms. Recently,…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Ruohua Shi , Qiufan Pang , Lei Ma , Lingyu Duan , Tiejun Huang , Tingting Jiang

Executable programs are highly structured files that can be recognized by operating systems and loaded into memory, analyzed for their dependencies, allocated resources, and ultimately executed. Each section of an executable program…

Cryptography and Security · Computer Science 2024-06-07 Wanhu Nie

Probabilistic circuits (PCs) are a promising avenue for probabilistic modeling, as they permit a wide range of exact and efficient inference routines. Recent ``deep-learning-style'' implementations of PCs strive for a better scalability,…

Simulation of atomic resolution image formation in scanning transmission electron microscopy can require significant computation times using traditional methods. A recently developed method, termed plane-wave reciprocal-space interpolated…

Computational Physics · Physics 2017-07-07 Alan Pryor , Colin Ophus , Jianwei Miao

Neuron segmentation from electron microscopy (EM) volumes is crucial for understanding brain circuits, yet the complex neuronal structures in high-resolution EM images present significant challenges. EM data exhibits unique characteristics…

Computer Vision and Pattern Recognition · Computer Science 2025-08-26 Yinda Chen , Haoyuan Shi , Xiaoyu Liu , Te Shi , Ruobing Zhang , Dong Liu , Zhiwei Xiong , Feng Wu

Single particle cryo-electron microscopy has become a critical tool in structural biology over the last decade, able to achieve atomic scale resolution in three dimensional models from hundreds of thousands of (noisy) two-dimensional…

Numerical Analysis · Mathematics 2023-07-19 Aaditya V. Rangan , Leslie Greengard

Monitoring and Managing High Performance Computing (HPC) systems and environments generate an ever growing amount of data. Making sense of this data and generating a platform where the data can be visualized for system administrators and…

Databases · Computer Science 2019-02-12 Rebecca Wild , Matthew Hubbell , Jeremy Kepner

We present FabSim, a toolkit developed to simplify a range of computational tasks for researchers in diverse disciplines. FabSim is flexible, adaptable, and allows users to perform a wide range of tasks with ease. It also provides a…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-09-21 Derek Groen , Agastya Bhati , James Suter , James Hetherington , Stefan Zasada , Peter Coveney

Cryo-electron microscopy (cryo-EM) studies using single particle reconstruction is extensively used to reveal structural information of macromolecular complexes. Aiming at the highest achievable resolution, state of the art electron…

Computer Vision and Pattern Recognition · Computer Science 2020-05-04 Ramin Norousi , Stephan Wickles , Thomas Becker , Roland Beckmann , Volker J. Schmid , Achim Tresch

This study presents a comprehensive workflow for investigating particulate materials through combined 360{\deg} electron tomography (ET), nano-computed X-ray tomography (nanoCT), and micro-computed X-ray tomography (microCT), alongside a…

High-throughput imaging workflows, such as Parallel Rapid Imaging with Spectroscopic Mapping (PRISM), generate data at rates that exceed conventional real-time processing capabilities. We present a scalable FPGA-based preprocessing pipeline…

Hardware Architecture · Computer Science 2025-11-26 Weichien Liao

The formation of biomolecular materials via dynamical interfacial processes such as self-assembly and fusion, for diverse compositions and external conditions, can be efficiently probed using ensemble Molecular Dynamics. However, this…

Traditional neuroimage analysis pipelines involve computationally intensive, time-consuming optimization steps, and thus, do not scale well to large cohort studies with thousands or tens of thousands of individuals. In this work we propose…

Image and Video Processing · Electrical Eng. & Systems 2020-06-11 Leonie Henschel , Sailesh Conjeti , Santiago Estrada , Kersten Diers , Bruce Fischl , Martin Reuter

Proper quality control (QC) is time consuming when working with large-scale medical imaging datasets, yet necessary, as poor-quality data can lead to erroneous conclusions or poorly trained machine learning models. Most efforts to reduce…

Developing complex biomolecular workflows is not always straightforward. It requires tedious developments to enable the interoperability between the different biomolecular simulation and analysis tools. Moreover, the need to execute the…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-12-20 Jorge Ejarque , Pau Andrio , Adam Hospital , Javier Conejero , Daniele Lezzi , Josep LL. Gelpi , Rosa M. Badia

Euler-Lagrange (EL) simulations provide a direct and robust framework for modeling disperse multiphase flows. However, they are computationally expensive. While various approaches have attempted to leverage heterogeneous computing…

Computational Engineering, Finance, and Science · Computer Science 2026-03-31 Silvio Schmalfuß , Sergey Lesnik , Henrik Rusche , Dennis Niedermeier

Brain-computer interfaces (BCIs) offer transformative potential, but decoding neural signals presents significant challenges. The core premise of this paper is built around demonstrating methods to elucidate the underlying low-dimensional…

Machine Learning · Computer Science 2025-02-28 Benjamin J. Choi