Neuron segmentation from electron microscopy (EM) volumes is crucial for understanding brain circuits, yet the complex neuronal structures in high-resolution EM images present significant challenges. EM data exhibits unique characteristics including high noise levels, anisotropic voxel dimensions, and ultra-long spatial dependencies that make traditional vision models inadequate. Inspired by autoregressive pretraining in language models, we propose TokenUnify, a hierarchical predictive coding framework that captures multi-scale dependencies through three complementary learning objectives. TokenUnify integrates random token prediction, next-token prediction, and next-all token prediction to create a comprehensive representational space with emergent properties. From an information-theoretic perspective, these three tasks are complementary and provide optimal coverage of visual data structure, with our approach reducing autoregressive error accumulation from O(K) to O(sqrt(K)) for sequences of length K. We also introduce a large-scale EM dataset with 1.2 billion annotated voxels, offering ideal long-sequence visual data with spatial continuity. Leveraging the Mamba architecture's linear-time sequence modeling capabilities, TokenUnify achieves a 44% performance improvement on downstream neuron segmentation and outperforms MAE by 25%. Our approach demonstrates superior scaling properties as model size increases, effectively bridging the gap between pretraining strategies for language and vision models.
@article{arxiv.2405.16847,
title = {TokenUnify: Scaling Up Autoregressive Pretraining for Neuron Segmentation},
author = {Yinda Chen and Haoyuan Shi and Xiaoyu Liu and Te Shi and Ruobing Zhang and Dong Liu and Zhiwei Xiong and Feng Wu},
journal= {arXiv preprint arXiv:2405.16847},
year = {2025}
}