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Structural microvascular alterations and dysfunction serve as key disease indicators of cancer, diabetes, ischemic stroke, neurodegenerative disorders and many other conditions. In vivo visualization of the microvasculature has…

Biological Physics · Physics 2020-07-02 Xosé Luís Deán-Ben , Justine Robin , Ruiqing Ni , Daniel Razansky

Beamforming is an essential step in the ultrasound image formation pipeline and has recently attracted growing interest. An important goal of beamforming is to increase the image spatial resolution, or in other words to narrow down the…

Image and Video Processing · Electrical Eng. & Systems 2022-09-01 Sobhan Goudarzi , Adrian Basarab , Hassan Rivaz

Ultrasound super-localization microscopy techniques presented in the last few years enable non-invasive imaging of vascular structures at the capillary level by tracking the flow of ultrasound contrast agents (gas microbubbles). However,…

Tissues and Organs · Quantitative Biology 2016-08-10 Avinoam Bar-Zion , Charles Tremblay-Darveau , Oren Solomon , Dan Adam , Yonina C. Eldar

We propose a deconvolution algorithm for images blurred and degraded by a Poisson noise. The algorithm uses a fast proximal backward-forward splitting iteration. This iteration minimizes an energy which combines a \textit{non-linear} data…

Applications · Statistics 2008-12-18 François-Xavier Dupé , Jalal Fadili , Jean Luc Starck

Recent advances in photoacoustic (PA) imaging have enabled detailed images of microvascular structure and quantitative measurement of blood oxygenation or perfusion. Standard reconstruction methods for PA imaging are based on solving an…

Signal Processing · Electrical Eng. & Systems 2020-04-17 MinWoo Kim , Geng-Shi Jeng , Ivan Pelivanov , Matthew O'Donnell

High resolution transcranial ultrasound imaging in humans has been a persistent challenge for ultrasound due to the imaging degradation effects from aberration and reverberation. These mechanisms depend strongly on skull morphology and they…

Medical Physics · Physics 2018-11-28 Danai E. Soulioti , David Espíndola , Paul A. Dayton , Gianmarco Pinton

The most ubiquitous form of computational aberration correction for microscopy is deconvolution. However, deconvolution relies on the assumption that the point spread function is the same across the entire field-of-view. This assumption is…

Image and Video Processing · Electrical Eng. & Systems 2025-04-30 Amit Kohli , Anastasios N. Angelopoulos , David McAllister , Esther Whang , Sixian You , Kyrollos Yanny , Federico M. Gasparoli , Bo-Jui Chang , Reto Fiolka , Laura Waller

We have shown that the left side null space of the autoregression (AR) matrix operator is the lexicographical presentation of the point spread function (PSF) on condition the AR parameters are common for original and blurred images. The…

Computer Vision and Pattern Recognition · Computer Science 2012-06-19 Yu. A. Bunyak , O. Yu. Sofina , R. N. Kvetnyy

Fluorescence lifetime imaging microscopy (FLIM) is an important technique to understand the chemical micro-environment in cells and tissues since it provides additional contrast compared to conventional fluorescence imaging. When two…

Image and Video Processing · Electrical Eng. & Systems 2022-01-19 Varun Mannam , Xiaotong Yuan , Scott Howard

In this paper, a novel method to enhance Frequency Modulated Continuous Wave (FMCW) THz imaging resolution beyond its diffraction limit is proposed. Our method comprises two stages. Firstly, we reconstruct the signal in depth-direction…

Image and Video Processing · Electrical Eng. & Systems 2019-07-03 Tak Ming Wong , Matthias Kahl , Peter Haring Bolívar , Andreas Kolb

A lensfree spectral light-field fusion microscopy (LSLFM) system is presented for enabling contrast- and resolution-enhanced imaging of biological specimens. LSLFM consists of a pulsed multispectral lensfree microscope for capturing…

Richardson-Lucy deconvolution is widely used to restore images from degradation caused by the broadening effects of a point spread function and corruption by photon shot noise, in order to recover an underlying object. In practice, this is…

Computer Vision and Pattern Recognition · Computer Science 2024-11-05 Zachary H. Hendrix , Peter T. Brown , Tim Flanagan , Douglas P. Shepherd , Ayush Saurabh , Steve Pressé

Vascular segmentation extracts blood vessels from images and serves as the basis for diagnosing various diseases, like ophthalmic diseases. Ophthalmologists often require high-resolution segmentation results for analysis, which leads to…

Image and Video Processing · Electrical Eng. & Systems 2022-07-29 Yan Hu , Zhongxi Qiu , Dan Zeng , Li Jiang , Chen Lin , Jiang Liu

Single-shot volumetric fluorescence (SVF) imaging offers a significant advantage over traditional imaging methods that require scanning across multiple axial planes as it can capture biological processes with high temporal resolution. The…

Synthetic aperture sonar (SAS) image resolution is constrained by waveform bandwidth and array geometry. Specifically, the waveform bandwidth determines a point spread function (PSF) that blurs the locations of point scatterers in the…

Computer Vision and Pattern Recognition · Computer Science 2021-12-17 Albert Reed , Thomas Blanford , Daniel C. Brown , Suren Jayasuriya

Confocal and multi-photon microscopy are widely used for in-vivo fluorescence imaging of biological tissues such as the brain, offering non-invasive access up to ~1 mm depth without major loss in performance. A recently-developed…

We propose a solution to the image deconvolution problem where the convolution kernel or point spread function (PSF) is assumed to be only partially known. Small perturbations generated from the model are exploited to produce a few…

Data Analysis, Statistics and Probability · Physics 2015-06-04 Se Un Park , Nicolas Dobigeon , Alfred O. Hero

Acoustic-resolution optoacoustic microscopy (AR-OAM) retrieves anatomical and functional contrast from living tissues at depths not reachable with optical microscopy. The imaging performance of AR-OAM has been advanced with image…

Resolving arterial flows is essential for understanding cardiovascular pathologies, improving diagnosis, and monitoring patient condition. Ultrasound contrast imaging uses microbubbles to enhance the scattering of the blood pool, allowing…

Low fluence illumination sources can facilitate clinical transition of photoacoustic imaging because they are rugged, portable, affordable, and safe. However, these sources also decrease image quality due to their low fluence. Here, we…

Image and Video Processing · Electrical Eng. & Systems 2020-04-21 Ali Hariri , Kamran Alipour , Yash Mantri , Jurgen P. Schulze , Jesse V. Jokerst