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We propose a representation learning framework for medical diagnosis domain. It is based on heterogeneous network-based model of diagnostic data as well as modified metapath2vec algorithm for learning latent node representation. We compare…

Machine Learning · Computer Science 2020-01-24 Karol Antczak

Precision mental health requires treatment decisions that account for heterogeneous symptoms reflecting multiple clinical domains. However, existing methods for estimating individualized treatment effects (ITE) rely on a single summary…

Machine Learning · Computer Science 2026-03-31 Yuying Lu , Wenbo Fei , Yuanjia Wang , Molei Liu

The simultaneous application of multiple treatments is increasingly common in many fields, such as healthcare and marketing. In such scenarios, it is important to estimate the single treatment effects and the interaction treatment effects…

Methodology · Statistics 2025-11-14 Yuki Murakami , Takumi Hattori , Kohsuke Kubota

An individualized treatment rule (ITR) tailors treatments to a patient's specific characteristics. However, randomized controlled trials (RCTs) are often underpowered to detect the treatment effect heterogeneity needed for reliable ITR…

Methodology · Statistics 2026-04-14 Yuan Bian , Donglin Zeng , Hyun-Joon Yang , Leanne M. Williams , Yuanjia Wang

In several medical decision-making problems, such as antibiotic prescription, laboratory testing can provide precise indications for how a patient will respond to different treatment options. This enables us to "fully observe" all potential…

Machine Learning · Computer Science 2020-08-14 Soorajnath Boominathan , Michael Oberst , Helen Zhou , Sanjat Kanjilal , David Sontag

The widespread adoption of electronic health records has created new opportunities for translational clinical research, yet this promise remains constrained by fragmented data across privacy-siloed institutions and substantial heterogeneity…

Collaborative learning through latent shared feature representations enables heterogeneous clients to train personalized models with improved performance and reduced sample complexity. Despite empirical success and extensive study, the…

Machine Learning · Computer Science 2025-11-25 Xiaochun Niu , Lili Su , Jiaming Xu , Pengkun Yang

Despite the impressive advances achieved using deep learning for functional brain activity analysis, the heterogeneity of functional patterns and the scarcity of imaging data still pose challenges in tasks such as identifying neurological…

Image and Video Processing · Electrical Eng. & Systems 2025-05-30 Wenhui Cui , Haleh Akrami , Anand A. Joshi , Richard M. Leahy

Medical data range from genomic sequences and retinal photographs to structured laboratory results and unstructured clinical narratives. Although these modalities appear disparate, many encode convergent information about a single…

Quantitative Methods · Quantitative Biology 2025-06-06 Salil Patel

There is strong interest in estimating how the magnitude of treatment effects of an intervention vary across sub-groups of the population of interest. In our paper, we propose a two-study approach to first propose and then test…

Methodology · Statistics 2020-06-23 Rahul Ladhania , Amelia Haviland , Neeraj Sood , Edward Kennedy , Ateev Mehrotra

Cognitive neuroscience is enjoying rapid increase in extensive public brain-imaging datasets. It opens the door to large-scale statistical models. Finding a unified perspective for all available data calls for scalable and automated…

Machine Learning · Statistics 2019-05-16 Arthur Mensch , Julien Mairal , Danilo Bzdok , Bertrand Thirion , Gaël Varoquaux

Observational longitudinal studies are a common means to study treatment efficacy and safety in chronic mental illness. In many such studies, treatment changes may be initiated by either the patient or by their clinician and can thus vary…

Methodology · Statistics 2020-06-12 Zekun Xu , Eric Laber , Ana-Maria Staicu , Emanuel Severus

The need to evaluate treatment effectiveness is ubiquitous in most of empirical science, and interest in flexibly investigating effect heterogeneity is growing rapidly. To do so, a multitude of model-agnostic, nonparametric meta-learners…

Machine Learning · Statistics 2021-02-26 Alicia Curth , Mihaela van der Schaar

A common strategy in modern learning systems is to learn a representation that is useful for many tasks, a.k.a. representation learning. We study this strategy in the imitation learning setting for Markov decision processes (MDPs) where…

Machine Learning · Computer Science 2020-02-26 Sanjeev Arora , Simon S. Du , Sham Kakade , Yuping Luo , Nikunj Saunshi

We propose a unified look at jointly learning multiple vision tasks and visual domains through universal representations, a single deep neural network. Learning multiple problems simultaneously involves minimizing a weighted sum of multiple…

Computer Vision and Pattern Recognition · Computer Science 2022-08-31 Wei-Hong Li , Xialei Liu , Hakan Bilen

We propose a unified optimization framework that combines neural networks with dictionary learning to model complex interactions between resting state functional MRI and behavioral data. The dictionary learning objective decomposes patient…

Machine Learning · Computer Science 2024-11-21 Niharika Shimona D'Souza , Mary Beth Nebel , Nicholas Wymbs , Stewart Mostofsky , Archana Venkataraman

Effectively representing medical concepts and patients is important for healthcare analytical applications. Representing medical concepts for healthcare analytical tasks requires incorporating medical domain knowledge and prior information…

Machine Learning · Computer Science 2023-05-02 Shaodong Wang , Qing Li , Wenli Zhang

Estimating heterogeneous treatment effects is an important problem across many domains. In order to accurately estimate such treatment effects, one typically relies on data from observational studies or randomized experiments. Currently,…

Machine Learning · Statistics 2022-02-28 Tobias Hatt , Jeroen Berrevoets , Alicia Curth , Stefan Feuerriegel , Mihaela van der Schaar

Individualized treatment decisions can improve health outcomes, but using data to make these decisions in a reliable, precise, and generalizable way is challenging with a single dataset. Leveraging multiple randomized controlled trials…

Multimodal machine learning (MML) is rapidly reshaping the way mental-health disorders are detected, characterized, and longitudinally monitored. Whereas early studies relied on isolated data streams -- such as speech, text, or wearable…

Machine Learning · Computer Science 2025-06-25 Zahraa Al Sahili , Ioannis Patras , Matthew Purver
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