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This paper proposes a new method for analysis of adverse event data in clinical trials. The method is illustrated by application to data on 4 phase III clinical trials, two on breast cancer and two on diabetes mellitus.

Applications · Statistics 2018-06-04 Sharayu Paranjpe , Anil Gore

The increasing depth of parametric domain knowledge in large language models (LLMs) is fueling their rapid deployment in real-world applications. Understanding model vulnerabilities in high-stakes and knowledge-intensive tasks is essential…

Computation and Language · Computer Science 2024-12-02 R. Patrick Xian , Alex J. Lee , Satvik Lolla , Vincent Wang , Qiming Cui , Russell Ro , Reza Abbasi-Asl

Preventable adverse events as a result of medical errors present a growing concern in the healthcare system. As drug-drug interactions (DDIs) may lead to preventable adverse events, being able to extract DDIs from drug labels into a…

Computation and Language · Computer Science 2019-11-06 Tung Tran , Ramakanth Kavuluru , Halil Kilicoglu

We present a Bayesian dynamic borrowing (BDB) approach to enhance the quantitative identification of adverse events (AEs) in spontaneous reporting systems (SRSs). The method embeds a robust meta-analytic predictive (MAP) prior with a…

Computation and Language · Computer Science 2025-05-20 François Haguinet , Jeffery L Painter , Gregory E Powell , Andrea Callegaro , Andrew Bate

Extracting meaningful drug-related information chunks, such as adverse drug events (ADE), is crucial for preventing morbidity and saving many lives. Most ADEs are reported via an unstructured conversation with the medical context, so…

Computation and Language · Computer Science 2023-08-16 Jie Yang , Soyeon Caren Han , Siqu Long , Josiah Poon , Goran Nenadic

Document-Level Biomedical Relation Extraction (Bio-RE) aims to identify relations between biomedical entities within extensive texts, serving as a crucial subfield of biomedical text mining. Existing Bio-RE methods struggle with…

Computation and Language · Computer Science 2025-01-10 Yufei Shang , Yanrong Guo , Shijie Hao , Richang Hong

We propose a voting-driven semi-supervised approach to automatically acquire the typical duration of an event and use it as pseudo-labeled data. The human evaluation demonstrates that our pseudo labels exhibit surprisingly high accuracy and…

Computation and Language · Computer Science 2024-03-28 Felix Virgo , Fei Cheng , Lis Kanashiro Pereira , Masayuki Asahara , Ichiro Kobayashi , Sadao Kurohashi

In recent years, with the growing amount of biomedical documents, coupled with advancement in natural language processing algorithms, the research on biomedical named entity recognition (BioNER) has increased exponentially. However, BioNER…

Computation and Language · Computer Science 2020-09-22 Usman Naseem , Matloob Khushi , Vinay Reddy , Sakthivel Rajendran , Imran Razzak , Jinman Kim

We hypothesize that explicit integration of contextual information into an Multi-task Learning framework would emphasize the significance of context for boosting performance in jointly learning Named Entity Recognition (NER) and Relation…

Computation and Language · Computer Science 2021-02-23 Paul Barry , Sam Henry , Meliha Yetisgen , Bridget McInnes , Ozlem Uzuner

Named entity recognition (NER) of chemicals and drugs is a critical domain of information extraction in biochemical research. NER provides support for text mining in biochemical reactions, including entity relation extraction, attribute…

Computation and Language · Computer Science 2020-12-22 Jian Liu , Lei Gao , Sujie Guo , Rui Ding , Xin Huang , Long Ye , Qinghua Meng , Asef Nazari , Dhananjay Thiruvady

Safe and reliable natural language inference is critical for extracting insights from clinical trial reports but poses challenges due to biases in large pre-trained language models. This paper presents a novel data augmentation technique to…

Computation and Language · Computer Science 2024-04-16 Yuqi Wang , Zeqiang Wang , Wei Wang , Qi Chen , Kaizhu Huang , Anh Nguyen , Suparna De

Retrieval augmented generation (RAG) has been widely adopted to help Large Language Models (LLMs) to process tasks involving long documents. However, existing retrieval models are not designed for long document retrieval and fail to address…

Information Retrieval · Computer Science 2026-02-13 David Jiahao Fu , Lam Thanh Do , Jiayu Li , Kevin Chen-Chuan Chang

Entity recognition in Automatic Speech Recognition (ASR) is challenging for rare and domain-specific terms. In domains such as finance, medicine, and air traffic control, these errors are costly. If the entities are entirely absent from the…

Computation and Language · Computer Science 2026-03-18 Abhishek Kumar , Aashraya Sachdeva

In this paper, the authors propose TriBERTa, a supervised entity resolution system that utilizes a pre-trained large language model and a triplet loss function to learn representations for entity matching. The system consists of two steps:…

Computation and Language · Computer Science 2024-11-19 Xiaowei Xu , Bi T. Foua , Xingqiao Wang , Vivek Gunasekaran , John R. Talburt

In this research, we present our work participation for the DrugProt task of BioCreative VII challenge. Drug-target interactions (DTIs) are critical for drug discovery and repurposing, which are often manually extracted from the…

Computation and Language · Computer Science 2021-11-09 Jehad Aldahdooh , Ziaurrehman Tanoli , Jing Tang

We tackle the task of building supervised event trigger identification models which can generalize better across domains. Our work leverages the adversarial domain adaptation (ADA) framework to introduce domain-invariance. ADA uses…

Computation and Language · Computer Science 2020-05-26 Aakanksha Naik , Carolyn Rosé

Clinical texts, represented in electronic medical records (EMRs), contain rich medical information and are essential for disease prediction, personalised information recommendation, clinical decision support, and medication pattern mining…

Computation and Language · Computer Science 2023-10-10 Hangyu Tu , Lifeng Han , Goran Nenadic

Biomedical event extraction is an information extraction task to obtain events from biomedical text, whose targets include the type, the trigger, and the respective arguments involved in an event. Traditional biomedical event extraction…

Computation and Language · Computer Science 2024-03-20 Pengchao Wu , Xuefeng Li , Jinghang Gu , Longhua Qian , Guodong Zhou

The application of Natural Language Processing (NLP) to specialized domains, such as the law, has recently received a surge of interest. As many legal services rely on processing and analyzing large collections of documents, automating such…

Computation and Language · Computer Science 2022-12-19 Wenyue Hua , Yuchen Zhang , Zhe Chen , Josie Li , Melanie Weber

Bioinformatics workflows are essential for complex biological data analyses and are often described in scientific articles with source code in public repositories. Extracting detailed workflow information from articles can improve…

Computation and Language · Computer Science 2025-03-11 Clémence Sebe , Sarah Cohen-Boulakia , Olivier Ferret , Aurélie Névéol