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In recent years, functional linear models have attracted growing attention in statistics and machine learning, with the aim of recovering the slope function or its functional predictor. This paper considers online regularized learning…

Machine Learning · Statistics 2022-11-28 Yuan Mao , Zheng-Chu Guo

Causal and nonparametric estimands in economics and biostatistics can often be viewed as the mean of a linear functional applied to an unknown outcome regression function. Naively learning the regression function and taking a sample mean of…

Machine Learning · Statistics 2025-11-12 Christian L. Hines , Oliver J. Hines

We propose an approach to reduce the bias of ridge regression and regularization kernel network. When applied to a single data set the new algorithms have comparable learning performance with the original ones. When applied to incremental…

Machine Learning · Statistics 2016-03-17 Qiang Wu

Molecular circuits capable of autonomous learning could unlock novel applications in fields such as bioengineering and synthetic biology. To this end, existing chemical implementations of neural computing have mainly relied on emulating…

Machine Learning · Computer Science 2025-09-23 Rajiv Teja Nagipogu , John H. Reif

In this study, we propose a neural network approach to capture the functional connectivities among anatomic brain regions. The suggested approach estimates a set of brain networks, each of which represents the connectivity patterns of a…

Computer Vision and Pattern Recognition · Computer Science 2018-07-24 Baran Baris Kivilcim , Itir Onal Ertugrul , Fatos T. Yarman Vural

We investigate the functioning of a classifying biological neural network from the perspective of statistical learning theory, modelled, in a simplified setting, as a continuous-time stochastic recurrent neural network (RNN) with identity…

Machine Learning · Statistics 2023-09-13 Wiebke Bartolomaeus , Youness Boutaib , Sandra Nestler , Holger Rauhut

Mathematical optimization is widely used in various research fields. With a carefully-designed objective function, mathematical optimization can be quite helpful in solving many problems. However, objective functions are usually…

Machine Learning · Computer Science 2019-05-27 Younghan Jeon , Minsik Lee , Jin Young Choi

A recent breakthrough in biologically-plausible normative frameworks for dimensionality reduction is based upon the similarity matching cost function and the low-rank matrix approximation problem. Despite clear biological interpretation,…

Neurons and Cognition · Quantitative Biology 2025-06-09 Veronica Centorrino , Francesco Bullo , Giovanni Russo

Neural network models offer a theoretical testbed for the study of learning at the cellular level. The only experimentally verified learning rule, Hebb's rule, is extremely limited in its ability to train networks to perform complex tasks.…

adap-org · Physics 2008-02-03 Russell W. Anderson

Conventional hyperparameter optimization methods are computationally intensive and hard to generalize to scenarios that require dynamically adapting hyperparameters, such as life-long learning. Here, we propose an online hyperparameter…

Machine Learning · Computer Science 2021-04-09 Daniel Jiwoong Im , Cristina Savin , Kyunghyun Cho

Despite its size and complexity, the human cortex exhibits striking anatomical regularities, suggesting there may simple meta-algorithms underlying cortical learning and computation. We expect such meta-algorithms to be of interest since…

Machine Learning · Computer Science 2013-10-25 David Balduzzi

Despite our extensive knowledge of biophysical properties of neurons, there is no commonly accepted algorithmic theory of neuronal function. Here we explore the hypothesis that single-layer neuronal networks perform online symmetric…

Neurons and Cognition · Quantitative Biology 2015-05-06 Cengiz Pehlevan , Dmitri B. Chklovskii

We propose a novel unsupervised learning framework for solving nonlinear optimal control problems (OCPs) with input constraints in real-time. In this framework, a neural network (NN) learns to predict the optimal co-state trajectory that…

Systems and Control · Electrical Eng. & Systems 2025-07-17 Lihan Lian , Yuxin Tong , Uduak Inyang-Udoh

Regulatory networks describe the interactions between molecular or cellular regulators, like transcription factors and genes in gene regulatory networks, kinases and their receptors in signalling networks, or neurons in neural networks. A…

Molecular Networks · Quantitative Biology 2022-12-29 Niklas Bonacker , Johannes Berg

Bayesian Networks may be appealing for clinical decision-making due to their inclusion of causal knowledge, but their practical adoption remains limited as a result of their inability to deal with unstructured data. While neural networks do…

Machine Learning · Computer Science 2022-11-16 Paloma Rabaey , Cedric De Boom , Thomas Demeester

A popular theory of perceptual processing holds that the brain learns both a generative model of the world and a paired recognition model using variational Bayesian inference. Most hypotheses of how the brain might learn these models assume…

Neurons and Cognition · Quantitative Biology 2021-06-01 Ari S. Benjamin , Konrad P. Kording

Online-learning literature has focused on designing algorithms that ensure sub-linear growth of the cumulative long-term constraint violations. The drawback of this guarantee is that strictly feasible actions may cancel out constraint…

Optimization and Control · Mathematics 2019-10-22 Ezra Tampubolon , Holger Boche

Information measures are often used to assess the efficacy of neural networks, and learning rules can be derived through optimization procedures on such measures. In biological neural networks, computation is restricted by the amount of…

Neurons and Cognition · Quantitative Biology 2021-03-12 Dmytro Grytskyy , Renaud B. Jolivet

The response time of physical computational elements is finite, and neurons are no exception. In hierarchical models of cortical networks each layer thus introduces a response lag. This inherent property of physical dynamical systems…

Neurons and Cognition · Quantitative Biology 2021-10-28 Paul Haider , Benjamin Ellenberger , Laura Kriener , Jakob Jordan , Walter Senn , Mihai A. Petrovici

We develop a neural-network framework for multi-period risk--reward stochastic control problems with constrained two-step feedback policies that may be discontinuous in the state. We allow a broad class of objectives built on a…

Computational Finance · Quantitative Finance 2026-03-09 Chang Chen , Duy-Minh Dang