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This paper adds to the growing literature of reinforcement learning (RL) for healthcare by proposing a novel paradigm: augmenting any predictor with Rule-based RL Layer (RRLL) that corrects the model's physiologically impossible…

Machine Learning · Computer Science 2025-02-03 Lingwei Zhu , Zheng Chen , Yukie Nagai , Jimeng Sun

Electronic Health Records (EHR) are high-dimensional data with implicit connections among thousands of medical concepts. These connections, for instance, the co-occurrence of diseases and lab-disease correlations can be informative when…

Machine Learning · Computer Science 2021-03-29 Weicheng Zhu , Narges Razavian

Accurate and explainable health event predictions are becoming crucial for healthcare providers to develop care plans for patients. The availability of electronic health records (EHR) has enabled machine learning advances in providing these…

Machine Learning · Computer Science 2021-05-18 Chang Lu , Chandan K. Reddy , Prithwish Chakraborty , Samantha Kleinberg , Yue Ning

Drug recommendation (DR) systems aim to support healthcare professionals in selecting appropriate medications based on patients' medical conditions. State-of-the-art approaches utilize deep learning techniques for improving DR, but fall…

Information Retrieval · Computer Science 2025-11-03 Yu Lin , Zhen Jia , Philipp Christmann , Xu Zhang , Shengdong Du , Tianrui Li

Integrating heterogeneous biomedical data including imaging, omics, and clinical records supports accurate diagnosis and personalised care. Graph-based models fuse such non-Euclidean data by capturing spatial and relational structure, yet…

Genomics · Quantitative Biology 2025-05-06 Alireza Sadeghi , Farshid Hajati , Ahmadreza Argha , Nigel H Lovell , Min Yang , Hamid Alinejad-Rokny

Non-communicable disease is the leading cause of death, emphasizing the need for accurate prediction of disease progression and informed clinical decision-making. Machine learning (ML) models have shown promise in this domain by capturing…

Machine Learning · Computer Science 2023-09-25 Zhoujian Sun , Wenzhuo Zhang , Zhengxing Huang , Nai Ding , Cheng Luo

The impact of machine learning models on healthcare will depend on the degree of trust that healthcare professionals place in the predictions made by these models. In this paper, we present a method to provide people with clinical expertise…

Machine Learning · Computer Science 2021-03-05 Aniruddh Raghu , John Guttag , Katherine Young , Eugene Pomerantsev , Adrian V. Dalca , Collin M. Stultz

Accurate prediction of clinical outcomes using Electronic Health Records (EHRs) is critical for early intervention, efficient resource allocation, and improved patient care. EHRs contain multimodal data, including both structured data and…

Machine Learning · Computer Science 2025-08-29 Rituparna Datta , Jiaming Cui , Zihan Guan , Vishal G. Reddy , Joshua C. Eby , Gregory Madden , Rupesh Silwal , Anil Vullikanti

Knowledge graph (KG) is used to represent data in terms of entities and structural relations between the entities. This representation can be used to solve complex problems such as recommendation systems and question answering. In this…

Artificial Intelligence · Computer Science 2022-12-09 Ajay Kumar Gogineni

Drug repositioning is an attractive cost-efficient strategy for the development of treatments for human diseases. Here, we propose an interpretable model that learns disease self-representations for drug repositioning. Our…

Deep learning methods exhibit promising performance for predictive modeling in healthcare, but two important challenges remain: -Data insufficiency:Often in healthcare predictive modeling, the sample size is insufficient for deep learning…

Machine Learning · Computer Science 2017-04-04 Edward Choi , Mohammad Taha Bahadori , Le Song , Walter F. Stewart , Jimeng Sun

Prediction of the future trajectory of a disease is an important challenge for personalized medicine and population health management. However, many complex chronic diseases exhibit large degrees of heterogeneity, and furthermore there is…

Machine Learning · Statistics 2016-08-17 Joseph Futoma , Mark Sendak , C. Blake Cameron , Katherine Heller

Epidemic outcomes have a complex interplay with human behavior and beliefs. Most of the forecasting literature has focused on the task of predicting epidemic signals using simple mechanistic models or black-box models, such as deep…

Machine Learning · Computer Science 2025-12-02 Mulin Tian , Ajitesh Srivastava

Over the years, reasoning over knowledge graphs (KGs), which aims to infer new conclusions from known facts, has mostly focused on static KGs. The unceasing growth of knowledge in real life raises the necessity to enable the inductive…

Computation and Language · Computer Science 2022-09-15 Yuanning Cui , Yuxin Wang , Zequn Sun , Wenqiang Liu , Yiqiao Jiang , Kexin Han , Wei Hu

Knowledge Graphs (KG) are of vital importance for multiple applications on the web, including information retrieval, recommender systems, and metadata annotation. Regardless of whether they are built manually by domain experts or with…

Computation and Language · Computer Science 2026-05-12 Daniel Daza , Michael Cochez , Paul Groth

Clinical decision-making is a feedback system where risk estimates influence treatment, which in turn changes disease trajectories, and both shape clinicians' measurement practices. Static prediction often fails clinically: models trained…

Artificial Intelligence · Computer Science 2026-05-19 Pujun Feng , Xiaoyu Guo , Seyed Ehsan Saffari , Min Hun Lee , Siew-Kei Lam , Erik Cambria , Xibin Sun , Yangtao Zhou , Tong Yang , Xiaoyu Zhang , Tao Tan , Yue Sun , Bin Cui

Walk-based models have shown their advantages in knowledge graph (KG) reasoning by achieving decent performance while providing interpretable decisions. However, the sparse reward signals offered by the KG during traversal are often…

Artificial Intelligence · Computer Science 2020-10-07 Deren Lei , Gangrong Jiang , Xiaotao Gu , Kexuan Sun , Yuning Mao , Xiang Ren

In this work, we present our various contributions to the objective of building a decision support tool for the diagnosis of rare diseases. Our goal is to achieve a state of knowledge where the uncertainty about the patient's disease is…

Offline reinforcement learning (RL) holds great promise for deriving optimal policies from observational data, but challenges related to interpretability and evaluation limit its practical use in safety-critical domains. Interpretability is…

Machine Learning · Computer Science 2025-07-24 Anton Matsson , Yaochen Rao , Heather J. Litman , Fredrik D. Johansson

Knowledge tracing aims to model students' past answer sequences to track the change in their knowledge acquisition during exercise activities and to predict their future learning performance. Most existing approaches ignore the fact that…

Machine Learning · Computer Science 2023-02-07 Yuqi Yue , Xiaoqing Sun , Weidong Ji , Zengxiang Yin , Chenghong Sun