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In a standard computed tomography (CT) image, pixels having the same Hounsfield Units (HU) can correspond to different materials and it is therefore challenging to differentiate and quantify materials. Dual-energy CT (DECT) is desirable to…

Medical Physics · Physics 2020-10-27 Wei Zhao , Tianling Lyu , Yang Chen , Lei Xing

Speckle contrast imaging is an established technique to obtain relative blood maps over wide field of views. Currently, its most accurate implementation relies on the acquisition of raw speckle images at different exposure times but…

Medical Physics · Physics 2021-10-01 Marc Chammas , Frédéric Pain

Spectral Computed Tomography (CT) is an emerging technology that enables to estimate the concentration of basis materials within a scanned object by exploiting different photon energy spectra. In this work, we aim at efficiently solving a…

Optimization and Control · Mathematics 2021-03-26 Alessandro Perelli , Martin S. Andersen

Material decomposition in X-ray imaging uses the energy-dependence of attenuation to virtually decompose an object into specific constituent materials. X-ray phase contrast imaging is a developing technique that can enhance image contrast…

With the development of computed tomography (CT) imaging technology, it is possible to acquire multi-energy data by spectral CT. Being different from conventional CT, the X-ray energy spectrum of spectral CT is cutting into several narrow…

Medical Physics · Physics 2023-01-25 Yuanwei He , Li Zeng , Qiong Xu , Zhe Wang , Haijun Yu , Zhaoqiang Shen , Zhaojun Yang , Rifeng Zhou

Background: Dual-energy CT (DECT) and material decomposition play vital roles in quantitative medical imaging. However, the decomposition process may suffer from significant noise amplification, leading to severely degraded image…

In a standard computed tomography (CT) image, pixels having the same Hounsfield Units (HU) can correspond to different materials and it is, therefore, challenging to differentiate and quantify materials. Dual-energy CT (DECT) is desirable…

Medical Physics · Physics 2019-11-01 Wei Zhao , Tianling Lv , Peng Gao , Liyue Shen , Xianjin Dai , Kai Cheng , Mengyu Jia , Yang Chen , Lei Xing

Many spectral CT applications require accurate material decomposition. Existing material decomposition algorithms are often susceptible to significant noise magnification or, in the case of one-step model-based approaches, hampered by slow…

Medical Physics · Physics 2025-07-22 Xiao Jiang , Grace J. Gang , J. Webster Stayman

Multi-energy CT has long demonstrated its ability to enhance image quality with material decomposition. Yet, it has largely been limited to applications that already have high contrast. More recently, x-ray phase-contrast (XPC) imaging has…

Medical Physics · Physics 2025-08-19 Giavanna Jadick , Patrick La Rivière

Optical coherence tomography (OCT) is a prevalent imaging technique for retina. However, it is affected by multiplicative speckle noise that can degrade the visibility of essential anatomical structures, including blood vessels and tissue…

Image and Video Processing · Electrical Eng. & Systems 2021-07-12 Dewei Hu , Joseph D. Malone , Yigit Atay , Yuankai K. Tao , Ipek Oguz

Dual Energy Cone Beam Computed Tomography (DE-CBCT) is a promising technique for several medical applications, including dynamic angiography. Recently, a dynamical two-step method has been proposed : first, the water and iodine projections…

Medical Physics · Physics 2021-12-23 Frederic Jolivet , Georg Schramm , Johan Nuyts

Spectral CT has shown promise for high-sensitivity quantitative imaging and material decomposition. This work presents a new device called a spatial-spectral filter (SSF) which consists of a tiled array of filter materials positioned near…

Medical Physics · Physics 2020-10-16 Matthew Tivnan , Wenying Wang , Grace Gang , J. Webster Stayman

Coronary artery disease (CAD) is a cardiovascular condition with high morbidity and mortality. Intravascular optical coherence tomography (IVOCT) has been considered as an optimal imagining system for the diagnosis and treatment of CAD.…

Image and Video Processing · Electrical Eng. & Systems 2022-04-26 Xueshen Li , Shengting Cao , Hongshan Liu , Xinwen Yao , Brigitta C. Brott , Silvio H. Litovsky , Xiaoyu Song , Yuye Ling , Yu Gan

X-ray energy spectrum plays an essential role in imaging and related tasks. Due to the high photon flux of clinical CT scanners, most of the spectrum estimation methods are indirect and are usually suffered from various limitations. The…

Medical Physics · Physics 2016-04-19 Wei Zhao , Qiude Zhang , Tianye Niu

Phase-contrast X-ray imaging can improve the visibility of weakly absorbing objects (e.g. soft tissues) by an order of magnitude or more compared to conventional radiographs. Previously, it has been shown that combining phase retrieval with…

In this work, we introduce a new deep learning approach based on diffusion posterior sampling (DPS) to perform material decomposition from spectral CT measurements. This approach combines sophisticated prior knowledge from unsupervised…

Image and Video Processing · Electrical Eng. & Systems 2024-02-07 Xiao Jiang , Grace J. Gang , J. Webster Stayman

Photon-counting CT (PCCT) offers improved diagnostic performance through better spatial and energy resolution, but developing high-quality image reconstruction methods that can deal with these large datasets is challenging. Model-based…

Medical Physics · Physics 2022-08-09 Alma Eguizabal , Ozan Öktem , Mats U. Persson

SPECT (Single-photon Emission Computerized Tomography) and PET (Positron Emission Tomography) are essential medical imaging tools, for which the sampling angle number, scan time should be chosen carefully to compromise between image quality…

Medical Physics · Physics 2015-06-16 Xiaolin Zhou , Minkai Yun , Xuexiang Cao , Shuangquan Liu , Lu Wang , Xianchao Huang , Long Wei

Spectral and grating-based differential phase-contrast X-ray imaging are two emerging technologies that offer additional information compared with conventional attenuation-based X-ray imaging. In the case of spectral imaging,…

Medical Physics · Physics 2020-01-31 Korbinian Mechlem , Thorsten Sellerer , Manuel Viermetz , Julia Herzen , Franz Pfeiffer

X-ray energy spectrum plays an essential role in computed tomography (CT) imaging and related tasks. Due to the high photon flux of clinical CT scanners, most of spectrum estimation methods are indirect and usually suffered from various…

Medical Physics · Physics 2017-06-14 Wei Zhao , Lei Xing , Qiude Zhang , Qingguo Xie , Tianye Niu