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Spectral CT offers enhanced material discrimination over single-energy systems and enables quantitative estimation of basis material density images. Water/iodine decomposition in contrast-enhanced CT is one of the most widespread…

Medical Physics · Physics 2021-03-30 Matthew Tivnan , Grace Gang , Wenchao Cao , Nadav Shapira , Peter B. Noel , J. Webster Stayman

Material decomposition for imaging multiple contrast agents in a single acquisition has been made possible by spectral CT: a modality which incorporates multiple photon energy spectral sensitivities into a single data collection. This work…

Medical Physics · Physics 2020-08-11 Matthew Tivnan , Steven Tilley , J. Webster Stayman

Spectral CT has great potential for a variety of clinical applications due to the improved material discrimination with respect to conventional CT. Many clinical and preclinical spectral CT systems have two spectral channels for dual-energy…

Medical Physics · Physics 2020-10-17 Matthew Tivnan , Wenying Wang , J. Webster Stayman

Inferior soft-tissue contrast resolution is a major limitation of current CT scanners. The aim of the study is to improve the contrast resolution of CT scanners using dual-energy acquisition. Based on dual-energy material decomposition, the…

Medical Physics · Physics 2016-11-15 Wei Zhao , Lu Wan , Bo Zhang , Qiude Zhang , Tianye Niu

Spectral CT is an emerging modality that uses a data acquisition scheme with varied spectral responses to provide enhanced material discrimination in addition to the structural information of conventional CT. Existing clinical and…

Medical Physics · Physics 2020-10-16 Matthew Tivnan , Wenying Wang , Steven Tilley , Jeffrey H. Siewerdsen , J. Webster Stayman

Spectral photon-counting X-ray CT (sCT) opens up new possibilities for the quantitative measurement of materials in an object, compared to conventional energy-integrating CT or dual energy CT. However, achieving reliable and accurate…

Image and Video Processing · Electrical Eng. & Systems 2020-07-15 Bingqing Xie , Pei Niu , Ting Su , Valérie Kaftandjian , Loic Boussel , Philippe Douek Feng Yang , Philippe Duvauchelle , Yuemin Zhu

Purpose: Photon-counting computed tomography (PCCT) shows promise for medical imaging in regards to material separation and imaging of multiple contrast agents. However, many PCCT setups are under development and are not optimized for…

Background: Perfusion computed tomography (CT) images the dynamics of a contrast agent through the body over time, and is one of the highest X-ray dose scans in medical imaging. Recently, a theoretically justified reconstruction algorithm…

Medical Physics · Physics 2026-02-04 Namhoon Kim , Ashwin Pananjady , Amir Pourmorteza , Sara Fridovich-Keil

Many clinical applications depend critically on the accurate differentiation and classification of different types of materials in patient anatomy. This work introduces a unified framework for accurate nonlinear material decomposition and…

Medical Physics · Physics 2018-03-19 Wei Zhao , Don Vernekohl , Fei Han , Bin Han , Hao Peng , Lei Xing , James K Min

Material decomposition refers to using the energy dependence of material physical properties to differentiate materials in a sample, which is a very important application in computed tomography(CT). In propagation-based X-ray phase-contrast…

Medical Physics · Physics 2023-12-01 Suyu Liao , Huitao Zhang , Peng Zhang , Yining Zhu

Iodinated contrast media is essential for dual-energy computed tomography (DECT) angiography. Previous studies show that iodinated contrast media may cause side effects, and the interruption of the supply chain in 2022 led to a severe…

Image and Video Processing · Electrical Eng. & Systems 2023-08-28 Qing Lyu , Josh Tan , Megan E. Lipford , Chuang Niu , Micheal E. Zapadka , Christopher M. Lack , Jonathan D. Clemente , Christopher T. Whitlow , Ge Wang

Photon counting detectors (PCDs) offer promising advancements in computed tomography (CT) imaging by enabling the quantification and 3D imaging of contrast agents and tissue types through multi-energy projections. However, the accuracy of…

Medical Physics · Physics 2023-10-18 Juan C. R. Luna , Mini Das

Dual-energy computed tomography (CT) is to reconstruct images of an object from two projection datasets generated from two distinct x-ray source energy spectra. It can provide more accurate attenuation quantification than conventional CT…

Medical Physics · Physics 2018-05-15 Wenxiang Cong , Daniel Harrison , Yan Xi , Ge Wang

In this work, we perform direct material reconstruction from spectral CT data using a model based iterative reconstruction (MBIR) approach. Material concentrations are measured in volume fractions, whose total is constrained by a maximum of…

Image and Video Processing · Electrical Eng. & Systems 2023-09-29 Obaidullah Rahman , Ken Sauer , Connor Evans , Ryan Roeder

Background: Daily or weekly cone-beam computed tomography (CBCT) scans are commonly used for accurate patient positioning during the image-guided radiotherapy (IGRT) process, making it an ideal option for adaptive radiotherapy (ART)…

One of the advantages of spectral computed tomography (CT) is it can achieve accurate material components using the material decomposition methods. The image-based material decomposition is a common method to obtain specific material…

Image and Video Processing · Electrical Eng. & Systems 2019-10-18 Weiwen Wu , Peijun Chen , Vince Vardhanabhuti , Weifei Wu , Hengyong Yu

Multispectral computed tomography (CT) enables advanced material characterization by acquiring energy-resolved projection data. However, since the incoming X-ray flux is be distributed across multiple narrow energy bins, the photon count…

Dual-energy computed tomography (DECT) has been widely used to obtain quantitative elemental composition of imaged subjects for personalized and precise medical diagnosis. Compared with DECT leveraging advanced X-ray source and/or detector…

Medical Physics · Physics 2024-08-28 Qiaoxin Li , Ruifeng Chen , Peng Wang , Guotao Quan , Yanfeng Du , Dong Liang , Yinsheng Li

Three-dimensional digital subtraction angiography (3D-DSA) is a widely adopted technique for clinical evaluation of contrast-enhanced vasculatures. The distribution of a contrast agent such as iodine is often estimated via temporal…

Medical Physics · Physics 2023-10-18 Xiaoxuan Zhang , Xiao Jiang , Matthew Tivnan , J. Webster Stayman , Grace Gang

X-ray computed tomography (CT) based on photon counting detectors (PCD) extends standard CT by counting detected photons in multiple energy bins. PCD data can be used to increase the contrast-to-noise ratio (CNR), increase spatial…

Image and Video Processing · Electrical Eng. & Systems 2024-02-05 Natalie M. Jadue , Madhuri Nagare , Jonathan S. Maltz , Gregery T. Buzzard , Charles A. Bouman
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