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X-ray Fluorescence Computed Tomography(XFCT) is a prevalent experimental technique which is utilized to investigate the spatial distribution of elements in sample. The sensitivity of L-shell XFCT of some elements is lower than that of…
Whole-body PET/CT scan is an important tool for diagnosing various malignancies (e.g., malignant melanoma, lymphoma, or lung cancer), and accurate segmentation of tumors is a key part for subsequent treatment. In recent years, CNN-based…
List-mode positron emission tomography (PET) image reconstruction is an important tool for PET scanners with many lines-of-response and additional information such as time-of-flight and depth-of-interaction. Deep learning is one possible…
Dose reduction in computed tomography (CT) is essential for decreasing radiation risk in clinical applications. Iterative reconstruction is one of the most promising ways to compensate for the increased noise due to reduction of photon…
Dual energy CT (DECT) enhances tissue characterization because it can produce images of basis materials such as soft-tissue and bone. DECT is of great interest in applications to medical imaging, security inspection and nondestructive…
One popular strategy for image denoising is to design a generalized regularization term that is capable of exploring the implicit prior underlying data observation. Convolutional neural networks (CNN) have shown the powerful capability to…
Cone-beam computed tomography (CBCT) is routinely collected during image-guided radiation therapy (IGRT) to provide updated patient anatomy information for cancer treatments. However, CBCT images often suffer from streaking artifacts and…
Lung cancer is one of the deadliest diseases and the leading cause of illness and death. Since lung cancer cannot predicted at premature stage, it able to only be discovered more broadly once it has spread to other lung parts. The risk…
Spectral computed tomography based on a photon-counting detector (PCD) attracts more and more attentions since it has the capability to provide more accurate identification and quantitative analysis for biomedical materials. The limited…
In X-ray computed tomography (CT) imaging, the choice of reconstruction kernel is crucial as it significantly impacts the quality of clinical images. Different kernels influence spatial resolution, image noise, and contrast in various ways.…
We propose a provably convergent method, called Efficient Learned Descent Algorithm (ELDA), for low-dose CT (LDCT) reconstruction. ELDA is a highly interpretable neural network architecture with learned parameters and meanwhile retains…
Reconstruction of few-view x-ray Computed Tomography (CT) data is a highly ill-posed problem. It is often used in applications that require low radiation dose in clinical CT, rapid industrial scanning, or fixed-gantry CT. Existing analytic…
Quantifying material mass and electron density from computed tomography (CT) reconstructions can be highly valuable in certain medical practices, such as radiation therapy planning. However, uniquely parameterising the X-ray attenuation in…
Ensuring proper generalization is a critical challenge in applying data-driven methods for solving inverse problems in imaging, as neural networks reconstructing an image must perform well across varied datasets and acquisition geometries.…
Dual-energy computed tomography (DECT) is an advanced CT scanning technique enabling material characterization not possible with conventional CT scans. It allows the reconstruction of energy decay curves at each 3D image voxel, representing…
In this paper, we present a novel method for tomographic image reconstruction in SPECT imaging with a low number of projections. Deep convolutional neural networks (CNN) are employed in the new reconstruction method. Projection data from…
Large high-quality medical image datasets are difficult to acquire but necessary for many deep learning applications. For positron emission tomography (PET), reconstructed image quality is limited by inherent Poisson noise. We propose a…
Low dose computed tomography (LDCT) has attracted more and more attention in routine clinical diagnosis assessment, therapy planning, etc., which can reduce the dose of X-ray radiation to patients. However, the noise caused by low X-ray…
Dynamic positron emission tomography (PET) reconstruction often presents high noise due to the use of short duration frames to describe the kinetics of the radiotracer. Here we introduce a new method to calculate a kernel matrix to be used…
Kernel methods have been extensively utilized in machine learning for classification and prediction tasks due to their ability to capture complex non-linear data patterns. However, single kernel approaches are inherently limited, as they…