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Optical Coherence Tomography(OCT) is a non-invasive technique capturing cross-sectional area of the retina in micro-meter resolutions. It has been widely used as a auxiliary imaging reference to detect eye-related pathology and predict…

Image and Video Processing · Electrical Eng. & Systems 2022-09-01 Shuo Chen , Da Ma , Sieun Lee , Timothy T. L. Yu , Gavin Xu , Donghuan Lu , Karteek Popuri , Myeong Jin Ju , Marinko V. Sarunic , Mirza Faisal Beg

We present a frequency domain model of shot noise in the photodetection of ultrashort optical pulse trains using a time-varying analysis. Shot noise-limited photocurrent power spectral densities, signal-to-noise expressions, and shot noise…

Optics · Physics 2015-06-15 Franklyn Quinlan , Tara M. Fortier , Haifeng Jiang , Scott A. Diddams

Purpose: To develop a deep learning approach to de-noise optical coherence tomography (OCT) B-scans of the optic nerve head (ONH). Methods: Volume scans consisting of 97 horizontal B-scans were acquired through the center of the ONH using a…

Terahertz subwavelength imaging aims at developing THz microscopes able to resolve deeply subwavelength features. To improve the spatial resolution beyond the diffraction limit, a current trend is to use various subwavelength probes to…

We propose an image resolution improvement method for optical coherence tomography (OCT) based on sparse continuous deconvolution. Traditional deconvolution techniques such as Lucy-Richardson deconvolution suffers from the artifact…

Biological Physics · Physics 2023-04-11 Zhengyu Qiao , Yong Huang , Qun Hao

Optical coherence tomography (OCT) is a non-invasive imaging technique with extensive clinical applications in ophthalmology. OCT enables the visualization of the retinal layers, playing a vital role in the early detection and monitoring of…

This work presents a quantum-limited optomechanical sensing platform for real-time detection and discrimination of chiral molecules, based on a multilayer hybrid plasmonic-mechanical resonator. Leveraging quantum zero-point motion and…

Optics · Physics 2025-07-29 Giuseppina Simone

The detection of laser radiation originating from space is a positive indicator of Extra Terrestrial Intelligence (ETI). Thus far the optical search for ETI (OSETI) has looked for enhanced brightness in the form of either narrow-band…

Instrumentation and Methods for Astrophysics · Physics 2020-08-10 David M. Benton

Transmission optical coherence tomography (OCT) enables analysis of biological specimens in vitro through detection of forward scattered light. Up to now, transmission OCT was considered as a technique that cannot directly retrieve…

Optics · Physics 2024-05-24 Wojciech Krauze , Martyna Mazur , Arkadiusz Kuś

In this chapter a general mathematical model of Optical Coherence Tomography (OCT) is presented on the basis of the electromagnetic theory. OCT produces high resolution images of the inner structure of biological tissues. Images are…

Numerical Analysis · Mathematics 2016-04-19 Peter Elbau , Leonidas Mindrinos , Otmar Scherzer

In this paper, we design a Generative Adversarial Network (GAN)-based solution for super-resolution and segmentation of optical coherence tomography (OCT) scans of the retinal layers. OCT has been identified as a non-invasive and…

Image and Video Processing · Electrical Eng. & Systems 2022-06-29 Paria Jeihouni , Omid Dehzangi , Annahita Amireskandari , Ali Rezai , Nasser M. Nasrabadi

Modern optical coherence tomography (OCT) devices provide volumetric images with micrometer-scale spatial resolution and a temporal resolution beyond video rate. In this work, we analyze an OCT-based prototypical tracking system which…

Image and Video Processing · Electrical Eng. & Systems 2020-01-22 Matthias Schlüter , Lukas Glandorf , Johanna Sprenger , Martin Gromniak , Maximilian Neidhardt , Thore Saathoff , Alexander Schlaefer

The phase-code mode-locked (PCML) laser provides a configurable frequency comb light source for circular-ranging optical coherence tomography systems (CR-OCT). However, prior implementations of PCML suffered from high relative intensity…

Optics · Physics 2025-06-24 Tae-Shik Kim , Danielle J. Harper , Benjamin J. Vakoc

In today's clinics, a cellular-resolution view of the cornea can be achieved only with an in vivo confocal microscope (IVCM) in contact with the eye. Here, we present a common-path Full-field/Spectral-domain OCT microscope (FF/SD OCT),…

In recent years, there has been a growing interest in applying convolutional neural networks (CNNs) to low-level vision tasks such as denoising and super-resolution. Due to the coherent nature of the image formation process, optical…

Computer Vision and Pattern Recognition · Computer Science 2019-01-29 Ashkan Abbasi , Amirhassan Monadjemi , Leyuan Fang , Hossein Rabbani , Yi Zhang

We investigate the reduction of measurement-added noise in force sensing by analyzing its power spectral density (PSD) within a hybrid optomechanical system. The setup comprises of an optomechanical cavity equipped with a movable mirror…

Quantum Physics · Physics 2024-09-18 Alolika Roy , Amarendra K. Sarma

Low-dose computed tomography (LDCT) reconstruction is fundamentally challenged by severe noise and compromised data fidelity under reduced radiation exposure. Most existing methods operate either in the image or post-log projection domain,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Bin Huang , Xun Yu , Yikun Zhang , Yi Zhang , Yang Chen , Qiegen Liu

Optical diffraction tomography (ODT) is a three-dimensional (3D) label-free imaging technique. The 3D refractive index distribution of a sample can be reconstructed from multiple two-dimensional optical field images via ODT. Herein, we…

Optics · Physics 2021-02-03 Chansuk Park , Kyeoreh Lee , Yoonseok Baek , Yongkeun Park

Allying high-resolution with a large field-of-view (FOV) is of great importance in the fields of biology and medicine, but particularly challenging when imaging non-flat living samples such as the human retina. Indeed, high-resolution is…

With the introduction of spectral-domain optical coherence tomography (SDOCT), much larger image datasets are routinely acquired compared to what was possible using the previous generation of time-domain OCT. Thus, there is a critical need…

Computer Vision and Pattern Recognition · Computer Science 2015-08-06 Yankui Sun , Tian Zhang , Yue Zhao , Yufan He