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Multi-objective Bayesian optimization has been widely adopted in scientific experiment design, including drug discovery and hyperparameter optimization. In practice, regulatory or safety concerns often impose additional thresholds on…

Machine Learning · Computer Science 2025-04-22 Diantong Li , Fengxue Zhang , Chong Liu , Yuxin Chen

Large language models (LLMs) are increasingly used to translate natural-language optimization problems into mathematical formulations and solver code, but matching the reference objective value is not a reliable test of correctness: an…

Artificial Intelligence · Computer Science 2026-05-13 Zhong Li , Zihan Guo , Xiaohan Lu , Juntao Wang , Jie Song , Chao Shen , Jiageng Wu , Mingyang Sun

Originating in the artificial intelligence literature, optimistic planning (OP) is an algorithm that generates near-optimal control inputs for generic nonlinear discrete-time systems whose input set is finite. This technique is therefore…

Optimization and Control · Mathematics 2019-08-06 Mathieu Granzotto , Romain Postoyan , Lucian Buşoniu , Dragan Nešić , Jamal Daafouz

Scientific optimization problems are usually concerned with balancing multiple competing objectives, which come as preferences over both the outcomes of an experiment (e.g. maximize the reaction yield) and the corresponding input parameters…

Machine Learning · Computer Science 2025-01-28 Mohammad Haddadnia , Leonie Grashoff , Felix Strieth-Kalthoff

Query optimizers have long been considered as among the most complex components of a database engine, while the assessment of an optimizer's quality remains a challenging task. Indeed, existing performance benchmarks for database engines…

Databases · Computer Science 2016-08-10 Zhan Li , Olga Papaemmanouil , Mitch Cherniack

Developing large language models is expensive and involves making decisions with small experiments, typically by evaluating on large, multi-task evaluation suites. In this work, we analyze specific properties which make a benchmark more…

Computation and Language · Computer Science 2025-08-19 David Heineman , Valentin Hofmann , Ian Magnusson , Yuling Gu , Noah A. Smith , Hannaneh Hajishirzi , Kyle Lo , Jesse Dodge

As large language models (LLMs) reach high scores on established mathematical benchmarks, such as GSM8K and MATH, the research community has turned to International Mathematical Olympiad (IMO) problems to push the evaluation frontier.…

Artificial Intelligence · Computer Science 2025-09-10 Ziye Chen , Chengwei Qin , Yao Shu

Equilibrium sampling of biomolecules remains an unmet challenge after more than 30 years of atomistic simulation. Efforts to enhance sampling capability, which are reviewed here, range from the development of new algorithms to…

Biomolecules · Quantitative Biology 2010-09-16 Daniel M. Zuckerman

Large language models (LLMs) have been widely adopted in mathematical optimization in scientific scenarios for their extensive knowledge and advanced reasoning capabilities. Existing methods mainly focus on utilizing LLMs to solve…

Optimization and Control · Mathematics 2025-03-18 Qitan Lv , Tianyu Liu , Hong Wang

Large language models (LLMs) are increasingly applied to scientific research, yet existing evaluations often fail to reflect the fine-grained capabilities required in practice. Most benchmarks are manually curated or domain-generic,…

Optimizing discrete black-box functions is key in several domains, e.g. protein engineering and drug design. Due to the lack of gradient information and the need for sample efficiency, Bayesian optimization is an ideal candidate for these…

Large language models (LLMs) have shown potential in assisting scientific research, yet their ability to discover high-quality research hypotheses remains unexamined due to the lack of a dedicated benchmark. To address this gap, we…

Computation and Language · Computer Science 2026-04-21 Yujie Liu , Zonglin Yang , Tong Xie , Jinjie Ni , Ben Gao , Yuqiang Li , Shixiang Tang , Wanli Ouyang , Erik Cambria , Dongzhan Zhou

Robustness is a crucial factor for the successful deployment of robots in unstructured environments, particularly in the domain of Simultaneous Localization and Mapping (SLAM). Simulation-based benchmarks have emerged as a highly scalable…

Scientific machine learning research spans diverse domains and data modalities, yet existing benchmark efforts remain siloed and lack standardization. This makes novel and transformative applications of machine learning to critical…

Autonomous laboratories promise to accelerate discovery by coupling learning algorithms with robotic experimentation, yet adoption remains limited by fragmented software that separates high-level planning from low-level execution. Here we…

Computational Engineering, Finance, and Science · Computer Science 2025-12-29 Jing Gao , Junhan Chang , Haohui Que , Yanfei Xiong , Shixiang Zhang , Xianwei Qi , Zhen Liu , Jun-Jie Wang , Qianjun Ding , Xinyu Li , Ziwei Pan , Qiming Xie , Zhuang Yan , Junchi Yan , Linfeng Zhang

Cosmological parameter estimation is entering a new era. Large collaborations need to coordinate high-stakes analyses using multiple methods; furthermore such analyses have grown in complexity due to sophisticated models of cosmology and…

Cosmology and Nongalactic Astrophysics · Physics 2018-04-04 Joe Zuntz , Marc Paterno , Elise Jennings , Douglas Rudd , Alessandro Manzotti , Scott Dodelson , Sarah Bridle , Saba Sehrish , James Kowalkowski

Quantum classification faces two key challenges. First, the difficulty of distinguishing between different classes varies: some class pairs are easy to separate, while others are more challenging. Second, practical execution is affected by…

Quantum Physics · Physics 2026-04-21 Yuhang Tu , Shengmei Zhao , Le Wang , Anqi Zhang

We present a budget-free experimental setup and procedure for benchmarking numericaloptimization algorithms in a black-box scenario. This procedure can be applied with the COCO benchmarking platform. We describe initialization of and input…

Artificial Intelligence · Computer Science 2016-05-20 Nikolaus Hansen , Tea Tusar , Olaf Mersmann , Anne Auger , Dimo Brockhoff

In complex simulation environments, certain parameter space regions may result in non-convergent or unphysical outcomes. All parameters can therefore be labeled with a binary class describing whether or not they lead to valid results. In…

Applications · Statistics 2019-02-19 Raoul Heese , Michal Walczak , Tobias Seidel , Norbert Asprion , Michael Bortz

Algorithm Operating System (AlgOS) is an unopinionated, extensible, modular framework for algorithmic implementations. AlgOS offers numerous features: integration with Optuna for automated hyperparameter tuning; automated argument parsing…

Software Engineering · Computer Science 2025-04-08 Llewyn Salt , Marcus Gallagher