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Optical detection of nanoscale objects without relying on fluorescence is a current challenge due to their extremely weak interaction with light. Resonator-enhanced absorption microscopy is a novel tool to heavily boost the light-matter…

Control of the polarization state of light is essential for many technologies, but is often limited by weak light-matter interactions that necessitate long device path lengths or significantly reduce the signal intensity. Here, we…

On-chip holographic video is a convenient way to monitor biological samples simultaneously at high spatial resolution and over a wide field-of-view. However, due to the limited readout rate of digital detector arrays, one often faces a…

Optics · Physics 2016-12-08 Donghun Ryu , Zihao Wang , Kuan He , Roarke Horstmeyer , Oliver Cossairt

Plasmonic nanopores hold a significant promise for molecular sequencing, but their sensitivity and temporal resolution are constrained by limited signal strength and rapid translocation of molecules through the pore. Here we report an…

Optics · Physics 2026-05-12 Nageswar Reddy Sanamreddy , Paolo Vavassori

Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Paloma Casteleiro Costa , Parnian Ghapandar Kashani , Xuhui Liu , Alexander Chen , Ary Portes , Julien Bec , Laura Marcu , Aydogan Ozcan

Chiral sensitive techniques have been used to probe the fundamental symmetries of the universe, study biomolecular structures, and even develop safe drugs. As chiral signals are inherently weak and often suppressed by large backgrounds,…

Applied Physics · Physics 2019-01-29 Sotiris Droulias , Lykourgos Bougas

Lensless imaging is a popular research field for the advantages of small size, wide field-of-view and low aberration in recent years. However, some traditional lensless imaging methods suffer from slow convergence, mechanical errors and…

The change in refractive index around plasmonic nanoparticles upon binding to biomolecules is routinely used in localized surface plasmon resonance (LSPR) based biosensors and in bio-sensing platforms. In this study, the plasmon sensitivity…

Chemical Physics · Physics 2019-06-05 Masoud Shabaninezhad , Guda Ramakrishna

A home made DSP-controlled scanning probe microscope (SPM) system has been developed and its utilization as a tool for lithography on nanometer scale is reported. User-friendly graphic interface allows to directly perform nanolithography…

Materials Science · Physics 2007-05-23 Pasqualantonio Pingue , Paolo Baschieri , Cesare Ascoli , Michel Dayez

The hotspots, which are typically found in nanogaps between metal structures, are critical for the enhancement of the electromagnetic field. Surface-enhanced Raman scattering (SERS), a technique known for its exceptional sensitivity and…

The emerging optical multiplexing within nanoscale shows super-capacity in encoding information by using the time-domain fingerprints from uniform nanoparticles. However, the optical diffraction limit compromises the decoding throughput and…

Optics · Physics 2022-08-09 Baolei Liu , Jiayan Liao , Yiliao Song , Jie Lu , Jiajia Zhou , Fan Wang

Focusing electromagnetic energy to sub-wavelength dimensions has become an increasingly active field of research for a variety of applications such as Heat Assisted Magnetic Recording (HAMR), nanolithography, and nanoscale optical…

Aluminum, as a metallic material for plasmonics, is of great interest because it extends the applications of surface plasmon resonance into the ultraviolet (UV) region and excels noble metals in the natural abundance, cost and compatibility…

Materials Science · Physics 2014-12-11 Hsuan-Wei Liu , Fan-Cheng Lin , Shi-Wei Lin , Jau-Yang Wu , Sheng-Di Lin , Jer-Shing Huang

We developed a nanoplasmonic sensor platform employing the extraordinary optical properties of one-dimensional nanogratings patterned on 30nm-thick ultrathin Ag films. Excitation of Fano resonances in the ultrathin Ag nanogratings results…

Optics · Physics 2014-10-15 Beibei Zeng , Yongkang Gao , Filbert J. Bartoli

We report sensing of single nanoparticles using disordered metallic nanoisland substrates supporting surface plasmon polaritons (SPPs). Speckle patterns arising from leakage radiation of elastically scattered SPPs provides a unique…

Optics · Physics 2022-01-31 Hongki Lee , Joel Berk , Aaron Webster , Donghyun Kim , Matthew R Foreman

The Lamb shift of a quantum emitter very close to a plasmonic nanostructure, mainly induced by the higher-order plasmonic dark modes, can be three or more orders of magnitude larger than that in the free space and it is ultra-sensitive to…

Quantum Physics · Physics 2023-06-06 Zeyang Liao , Yuwei Lu , Xue-Hua Wang

We report for the first time on the anticorrelated emission of high-order harmonics and energetic electron beams from a solid-density plasma with a sharp vacuum interface$-$plasma mirror$-$driven by an intense ultrashort laser pulse. We…

We introduce a single-frame diffractive imaging method called randomized probe imaging (RPI). In RPI, a sample is illuminated by a structured probe field containing speckles smaller than the sample's typical feature size. Quantitative…

To overcome the limit of diffraction while achieving the superresolution technique, solid immersion lenses are the key optical elements for data storage and nanophotonics applications. Recent demonstrations have shown how different…

Optics · Physics 2026-02-24 Subhankar Roy , Jianping Hu , M Ummal Momeen

Surface plasmon resonance (SPR) has been intensively studied and widely employed for light trapping and absorption enhancement. In the mid-infrared and terahertz (THz) regime, graphene supports the tunable SPR via manipulating its Fermi…

Optics · Physics 2017-11-15 Shuyuan Xiao , Tao Wang , Yuebo Liu , Chen Xu , Xu Han , Xicheng Yan