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The cardiovascular and ocular systems are intricately connected, with hemodynamic interactions playing a crucial role in both physiological regulation and pathological conditions. However, existing models often treat these systems…
Aortic valve replacement is a key surgical procedure for treating aortic valve pathologies, such as stenosis and regurgitation. The precise placement of the prosthetic valve relative to the native aortic annulus plays a critical role in the…
We present a unified mathematical framework for modeling blood and lymph flow in biological vessels, with a particular focus on lymph transport through lymphangions. Starting from first principles, we rigorously derive a system of partial…
We investigate the steady-state fluid--structure interaction between a Newtonian fluid flow and a deformable microtube in two novel geometric configurations arising in recent microfluidics experiments. The first configuration is a…
Rule-based methods are often used for assigning fiber orientation to cardiac anatomical models. However, existing methods have been developed using data mostly from the left ventricle. As a consequence, fiber information obtained from…
We study the impact of using fluid-structure interactions (FSI) to simulate blood flow in a large stenosed artery. We compare typical flow configurations using Navier-Stokes in a rigid geometry setting to a fully coupled FSI model. The…
The flow simulation in alveolar region is imperative in understanding transport of particles and designing aerosol drug delivery systems. Air flow is dependent on alveolar geometry and ventilation conditions. In this work a three…
We present a theoretical description of the fluid--structure interaction observed within a Starling resistor. The typical setup consists of a pre-stretched finite length thin-walled elastic tube mounted between two rigid tubes. The…
In this paper we show and discuss the use of a versatile interaction potential approach coupled with an immersed boundary method to simulate a variety of flows involving deformable bodies. In particular, we focus on two kinds of problems,…
Image-based modeling is essential for understanding cardiovascular hemodynamics and advancing the diagnosis and treatment of cardiovascular diseases. Constructing patient-specific vascular models remains labor-intensive, error-prone, and…
Advances in computational science offer a principled pipeline for predictive modeling of cardiovascular flows and aspire to provide a valuable tool for monitoring, diagnostics and surgical planning. Such models can be nowadays deployed on…
The capability to accurately predict flood flows via numerical simulations is a key component of contemporary flood risk management practice. However, modern flood models lack the capacity to accurately model flow interactions with linear…
In this paper, we focus on investigating the influence on hydrodynamic factors of different coupled computational models describing the interaction between an incompressible fluid and two symmetric elastic or poroelastic structures. The…
This paper explores the fluid-elastic response of a cantilevered flexible sheet in the presence of uniform airflow. The leading edge of the sheet is clamped, while at the trailing edge, in-plane tension is applied to provide additional…
We present a comparative modelling study of fluid-structure interactions in microchannels. Through a mathematical analysis based on plate theory and the lubrication approximation for low-Reynolds-number flow, we derive models for the flow…
The unique working mechanics of roller-type peristaltic pumps have allowed their applications to span a wide variety of sectors and industries. The roller-type pump's accurate dosing and hydrostatic capabilities can theoretically allow for…
Fracture resistance of blood clots plays a crucial role in physiological hemostasis and pathological thromboembolism. Although recent experimental and computational studies uncovered the poro-viscoelastic property of blood clots and its…
This work extends the input-output approach to the study of wall-bounded shear flows manipulated using actuators common in experimental flow control studies. In particular, we adapt this powerful analytical framework to investigate the flow…
Here we develop a lung ventilation model, based a continuum poroelastic representation of lung parenchyma and a 0D airway tree flow model. For the poroelastic approximation we design and implement a lowest order stabilised finite element…
This work develops a low-dimensional nonlinear stochastic model of symmetry-breaking coherent structures from experimental measurements of a turbulent axisymmetric bluff body wake. Traditional model reduction methods decompose the field…