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Conditional independence testing is an important problem, yet provably hard without assumptions. One of the assumptions that has become popular of late is called "model-X", where we assume we know the joint distribution of the covariates,…

Methodology · Statistics 2020-07-14 Eugene Katsevich , Aaditya Ramdas

For testing conditional independence (CI) of a response Y and a predictor X given covariates Z, the recently introduced model-X (MX) framework has been the subject of active methodological research, especially in the context of MX knockoffs…

Statistics Theory · Mathematics 2022-11-01 Eugene Katsevich , Aaditya Ramdas

We consider the problem of conditional independence testing: given a response Y and covariates (X,Z), we test the null hypothesis that Y is independent of X given Z. The conditional randomization test (CRT) was recently proposed as a way to…

Methodology · Statistics 2021-06-07 Molei Liu , Eugene Katsevich , Lucas Janson , Aaditya Ramdas

We propose a new method named the Conditional Randomization Rank Test (CRRT) for testing conditional independence of a response variable Y and a covariate variable X, conditional on the rest of the covariates Z. The new method generalizes…

Methodology · Statistics 2021-12-02 Yanjie Zhong , Todd Kuffner , Soumendra Lahiri

The conditional randomization test (CRT) was recently proposed to test whether two random variables X and Y are conditionally independent given random variables Z. The CRT assumes that the conditional distribution of X given Z is known…

Machine Learning · Computer Science 2023-04-11 Shuai Li , Ziqi Chen , Hongtu Zhu , Christina Dan Wang , Wang Wen

Testing whether a variable of interest affects the outcome is one of the most fundamental problem in statistics and is often the main scientific question of interest. To tackle this problem, the conditional randomization test (CRT) is…

Methodology · Statistics 2023-05-26 Dae Woong Ham , Jiaze Qiu

Conditional independence tests are crucial across various disciplines in determining the independence of an outcome variable $Y$ from a treatment variable $X$, conditioning on a set of confounders $Z$. The Conditional Randomization Test…

Methodology · Statistics 2024-05-30 Bowen Xu , Yiwen Huang , Chuan Hong , Shuangning Li , Molei Liu

Conditional randomization tests (CRTs) assess whether a variable $x$ is predictive of another variable $y$, having observed covariates $z$. CRTs require fitting a large number of predictive models, which is often computationally…

Methodology · Statistics 2023-04-12 Mukund Sudarshan , Aahlad Manas Puli , Wesley Tansey , Rajesh Ranganath

Variable selection properties of procedures utilizing penalized-likelihood estimates is a central topic in the study of high dimensional linear regression problems. Existing literature emphasizes the quality of ranking of the variables by…

Statistics Theory · Mathematics 2022-04-28 Asaf Weinstein , Weijie J. Su , Małgorzata Bogdan , Rina F. Barber , Emmanuel J. Candès

The model-X conditional randomization test (CRT) is a flexible and powerful testing procedure for the conditional independence hypothesis: X is independent of Y conditioning on Z. Though having many attractive properties, the model-X CRT…

Methodology · Statistics 2023-05-02 Shuangning Li , Molei Liu

This paper introduces the sequential CRT, which is a variable selection procedure that combines the conditional randomization test (CRT) and Selective SeqStep+. Valid p-values are constructed via the flexible CRT, which are then ordered and…

Methodology · Statistics 2022-04-08 Shuangning Li , Emmanuel J. Candès

The model-X conditional randomization test is a generic framework for conditional independence testing, unlocking new possibilities to discover features that are conditionally associated with a response of interest while controlling type-I…

Machine Learning · Computer Science 2023-02-21 Shalev Shaer , Yaniv Romano

We consider testing multivariate conditional independence between a response Y and a covariate vector X given additional variables Z. We introduce the Multivariate Sufficient Statistic Conditional Randomization Test (MS-CRT), which…

Methodology · Statistics 2025-04-10 Xiaotong Lin , Jie Xie , Fangqiao Tian , Dongming Huang

Conditional independence (CI) testing arises naturally in many scientific problems and applications domains. The goal of this problem is to investigate the conditional independence between a response variable $Y$ and another variable $X$,…

Methodology · Statistics 2025-10-07 Adel Javanmard , Mohammad Mehrabi

Switchback experiments--alternating treatment and control over time--are widely used when unit-level randomization is infeasible, outcomes are aggregated, or user interference is unavoidable. In practice, experimentation must support fast…

Methodology · Statistics 2026-02-27 Jizhou Liu , Liang Zhong

The recent paper Cand\`es et al. (2018) introduced model-X knockoffs, a method for variable selection that provably and non-asymptotically controls the false discovery rate with no restrictions or assumptions on the dimensionality of the…

Methodology · Statistics 2020-06-16 Dongming Huang , Lucas Janson

Conditional independence (CI) testing is a fundamental task in modern statistics and machine learning. The conditional randomization test (CRT) was recently introduced to test whether two random variables, $X$ and $Y$, are conditionally…

Machine Learning · Statistics 2024-12-19 Yanfeng Yang , Shuai Li , Yingjie Zhang , Zhuoran Sun , Hai Shu , Ziqi Chen , Renming Zhang

Consider a case-control study in which we have a random sample, constructed in such a way that the proportion of cases in our sample is different from that in the general population---for instance, the sample is constructed to achieve a…

Methodology · Statistics 2019-01-01 Rina Foygel Barber , Emmanuel Candes

Model-X approaches to testing conditional independence between a predictor and an outcome variable given a vector of covariates usually assume exact knowledge of the conditional distribution of the predictor given the covariates.…

Methodology · Statistics 2023-02-10 Ziang Niu , Abhinav Chakraborty , Oliver Dukes , Eugene Katsevich

Researchers in biomedical studies often work with samples that are not selected uniformly at random from the population of interest, a major example being a case-control study. While these designs are motivated by specific scientific…

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