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Retrosynthesis, the process of breaking down a target molecule into simpler precursors through a series of valid reactions, stands at the core of organic chemistry and drug development. Although recent machine learning (ML) research has…

Artificial Intelligence · Computer Science 2026-05-12 Haorui Wang , Jeff Guo , Lingkai Kong , Rampi Ramprasad , Philippe Schwaller , Yuanqi Du , Chao Zhang

While inorganic retrosynthesis planning is essential in the field of chemical science, the application of machine learning in this area has been notably less explored compared to organic retrosynthesis planning. In this paper, we propose…

Machine Learning · Computer Science 2025-10-14 Heewoong Noh , Namkyeong Lee , Gyoung S. Na , Chanyoung Park

Parameter transfer is a central paradigm in transfer learning, enabling knowledge reuse across tasks and domains by sharing model parameters between upstream and downstream models. However, when only a subset of parameters from the upstream…

Machine Learning · Computer Science 2026-01-08 Hua Yuan , Xuran Meng , Qiufeng Wang , Shiyu Xia , Ning Xu , Xu Yang , Jing Wang , Xin Geng , Yong Rui

MOTIVATION: Proteins fold into complex structures that are crucial for their biological functions. Experimental determination of protein structures is costly and therefore limited to a small fraction of all known proteins. Hence, different…

Biomolecules · Quantitative Biology 2018-04-18 David Menéndez Hurtado , Karolis Uziela , Arne Elofsson

Precise load forecasting in buildings could increase the bill savings potential and facilitate optimized strategies for power generation planning. With the rapid evolution of computer science, data-driven techniques, in particular the Deep…

Machine Learning · Computer Science 2023-01-30 Menna Nawar , Moustafa Shomer , Samy Faddel , Huangjie Gong

Transfer learning aims to leverage models pre-trained on source data to efficiently adapt to target setting, where only limited data are available for model fine-tuning. Recent works empirically demonstrate that adversarial training in the…

Machine Learning · Computer Science 2021-06-21 Zhun Deng , Linjun Zhang , Kailas Vodrahalli , Kenji Kawaguchi , James Zou

Transfer learning is a machine learning technique that uses previously acquired knowledge from a source domain to enhance learning in a target domain by reusing learned weights. This technique is ubiquitous because of its great advantages…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Nermeen Abou Baker , Nico Zengeler , Uwe Handmann

Data-driven methods -- such as machine learning and time series forecasting -- are widely used for sales forecasting in the food retail domain. However, for newly introduced products insufficient training data is available to train accurate…

Machine Learning · Computer Science 2020-05-15 Tristan Karb , Niklas Kühl , Robin Hirt , Varvara Glivici-Cotruta

Fine-tuning through knowledge transfer from a pre-trained model on a large-scale dataset is a widely spread approach to effectively build models on small-scale datasets. In this work, we show that a recent adversarial attack designed for…

Machine Learning · Computer Science 2021-04-30 Ting-Wu Chin , Cha Zhang , Diana Marculescu

We propose TANDA, an effective technique for fine-tuning pre-trained Transformer models for natural language tasks. Specifically, we first transfer a pre-trained model into a model for a general task by fine-tuning it with a large and…

Computation and Language · Computer Science 2019-11-21 Siddhant Garg , Thuy Vu , Alessandro Moschitti

Transfer learning has emerged as a powerful technique in many application problems, such as computer vision and natural language processing. However, this technique is largely ignored in application to genetic data analysis. In this paper,…

Applications · Statistics 2022-06-22 Jinghang Lin , Shan Zhang , Qing Lu

Transfer learning refers to the promising idea of initializing model fits based on pre-training on other data. We particularly consider regression modeling settings where parameter estimates from previous data can be used as anchoring…

Methodology · Statistics 2020-07-07 Wessel N. van Wieringen , Harald Binder

Accelerating learning processes for complex tasks by leveraging previously learned tasks has been one of the most challenging problems in reinforcement learning, especially when the similarity between source and target tasks is low. This…

Machine Learning · Computer Science 2021-05-27 Yunzhe Tao , Sahika Genc , Jonathan Chung , Tao Sun , Sunil Mallya

As a fundamental problem in transfer learning, model selection aims to rank off-the-shelf pre-trained models and select the most suitable one for the new target task. Existing model selection techniques are often constrained in their scope…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Jiameng Bai , Sai Wu , Jie Song , Junbo Zhao , Gang Chen

Retrosynthesis prediction focuses on identifying reactants capable of synthesizing a target product. Typically, the retrosynthesis prediction involves two phases: Reaction Center Identification and Reactant Generation. However, we argue…

Artificial Intelligence · Computer Science 2025-01-15 Shengyin Sun , Wenhao Yu , Yuxiang Ren , Weitao Du , Liwei Liu , Xuecang Zhang , Ying Hu , Chen Ma

The recent proliferation of Data Grids and the increasingly common practice of using resources as distributed data stores provide a convenient environment for communities of researchers to share, replicate, and manage access to copies of…

Distributed, Parallel, and Cluster Computing · Computer Science 2007-05-23 Sudharshan Vazhkudai , Jennifer M. Schopf

In low-resource settings, model transfer can help to overcome a lack of labeled data for many tasks and domains. However, predicting useful transfer sources is a challenging problem, as even the most similar sources might lead to unexpected…

Computation and Language · Computer Science 2021-11-01 Lukas Lange , Jannik Strötgen , Heike Adel , Dietrich Klakow

Transfer learning is widely used to adapt large pretrained models to new tasks with only a small amount of new data. However, a challenge persists -- the features from the original task often do not fully cover what is needed for unseen…

Machine Learning · Computer Science 2026-02-10 Xingyu Alice Yang , Jianyu Zhang , Léon Bottou

The impressive performance of deep learning architectures is associated with a massive increase in model complexity. Millions of parameters need to be tuned, with training and inference time scaling accordingly, together with energy…

Machine Learning · Computer Science 2023-11-10 Paolo Didier Alfano , Vito Paolo Pastore , Lorenzo Rosasco , Francesca Odone

Development of comprehensive prediction models are often of great interest in many disciplines of science, but datasets with information on all desired features often have small sample sizes. We describe a transfer learning approach for…

Methodology · Statistics 2024-08-20 Ruzhang Zhao , Prosenjit Kundu , Arkajyoti Saha , Nilanjan Chatterjee