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Cardiac motion over a cardiac cycle is crucial for quantifying regional function and is strongly affected by cardiovascular diseases. Since temporally dense mesh sequences are difficult to obtain in practice, we focus on leveraging the more…

Computer Vision and Pattern Recognition · Computer Science 2026-05-21 Xuan Yang , Xiaohan Yuan , Hao Li , Lingyu Chen , Yanan Liu , Lei Li

Despite recent advances in diagnosis and treatment, atherosclerotic coronary artery diseases remain a leading cause of death worldwide. Various imaging modalities and metrics can detect lesions and predict patients at risk; however,…

Computational Engineering, Finance, and Science · Computer Science 2024-05-24 Ross Straughan , Karim Kadry , Sahil A. Parikh , Elazer R. Edelman , Farhad R. Nezami

The dynamics of biomolecules are crucial for our understanding of their functioning in living systems. However, current 3D imaging techniques, such as cryogenic electron microscopy (cryo-EM), require freezing the sample, which limits the…

Quantitative Methods · Quantitative Biology 2023-08-24 Enze Ye , Yuhang Wang , Hong Zhang , Yiqin Gao , Huan Wang , He Sun

Digital twins for cardiac electrophysiology are an enabling technology for precision cardiology. Current forward models are advanced enough to simulate the cardiac electric activity under different pathophysiological conditions and…

Optimization and Control · Mathematics 2025-05-05 Thomas Grandits , Karli Gillette , Gernot Plank , Simone Pezzuto

Clinical measurements, such as body temperature, are often collected over time to monitor an individual's underlying health condition. These measurements exhibit complex temporal dynamics, necessitating sophisticated statistical models to…

Methodology · Statistics 2024-12-17 Xiaoran Ma , Wensheng Guo , Peter Kotanko , Yuedong Wang

Three-dimensional electrical capacitance tomography (3D-ECT) has shown promise for visualizing industrial multiphase flows. However, existing 3D-ECT approaches suffer from limited imaging resolution and lack assessment metrics, hampering…

Image and Video Processing · Electrical Eng. & Systems 2023-12-25 Shengnan Wang , Yi Li , Zhou Chen , Yunjie Yang

Although electrocardiograms (ECG) play a dominant role in cardiovascular diagnosis and treatment, their intrinsic data forms and representational patterns pose significant challenges for medical multimodal large language models (Med-MLLMs)…

To address the issue of computational efficiency related to the modelling of blood flow in complex networks, we derive a family of nonlinear lumped-parameter models for blood flow in compliant vessels departing from a well-established…

Numerical Analysis · Mathematics 2022-01-06 Beatrice Ghitti , Eleuterio F. Toro , Lucas O. Müller

Computational models of cardiac structure and function are increasingly central to the development of subject-specific cardiac digital twins, enabling improved characterization of contractile dysfunction, pathological remodeling, and…

Determining the 3D structures of biological molecules is a key problem for both biology and medicine. Electron Cryomicroscopy (Cryo-EM) is a promising technique for structure estimation which relies heavily on computational methods to…

Machine Learning · Statistics 2015-01-29 Ali Punjani , Marcus A. Brubaker

The forward problem in electrocardiology, computing body surface potentials from cardiac electrical activity, is traditionally solved using physics-based models such as the bidomain or monodomain equations. While accurate, these approaches…

Image and Video Processing · Electrical Eng. & Systems 2025-12-17 Shaheim Ogbomo-Harmitt , Cesare Magnetti , Chiara Spota , Jakub Grzelak , Oleg Aslanidi

Dynamic reconstructions (3D+T) of coronary arteries could give important perfusion details to clinicians. Temporal matching of the different views, which may not be acquired simultaneously, is a prerequisite for an accurate stereo-matching…

Computer Vision and Pattern Recognition · Computer Science 2020-09-08 Raphaël Royer-Rivard , Fantin Girard , Nagib Dahdah , Farida Cheriet

Patient-specific cardiac modeling combines geometries of the heart derived from medical images and biophysical simulations to predict various aspects of cardiac function. However, generating simulation-suitable models of the heart from…

Image and Video Processing · Electrical Eng. & Systems 2023-11-09 Fanwei Kong , Shawn Shadden

Hemodynamics in the aorta from computational fluid dynamics (CFD) simulations can provide a comprehensive analysis of relevant cardiovascular diseases. Coupling the three-element Windkessel model with the patient-specific CFD simulation to…

Fluid Dynamics · Physics 2022-07-14 Zongze Li , Wenbin Mao

Volume conductor problems in cerebral electrophysiology and bioimpedance do not have analytical solutions for nontrivial geometries and require a 3D model of the head and its electrical properties for solving the associated PDEs…

Medical Physics · Physics 2021-11-02 Fernando S Moura , Roberto G Beraldo , Leonardo A Ferreira , Samuli Siltanen

Electrocardiography (ECG) plays a central role in cardiovascular diagnostics, yet existing automated approaches often struggle to generalize across clinical tasks and offer limited support for open-ended reasoning. We present HeartLLM, a…

Artificial Intelligence · Computer Science 2026-01-27 Jinning Yang , Wenjie Sun , Wen Shi

Finite element analysis (FEA) forms the cornerstone of modeling cardiac biomechanics but is computationally expensive, limiting its clinical application for digital twin creation, which often requires tens to hundreds of simulations to…

Medical Physics · Physics 2025-04-29 Lei Shi , Yurui Chen , Vijay Vedula

We propose a novel neural deformable model (NDM) targeting at the reconstruction and modeling of 3D bi-ventricular shape of the heart from 2D sparse cardiac magnetic resonance (CMR) imaging data. We model the bi-ventricular shape using…

Computer Vision and Pattern Recognition · Computer Science 2024-11-25 Meng Ye , Dong Yang , Mikael Kanski , Leon Axel , Dimitris Metaxas

Since myocardial fibers drive the electric signal propagation throughout the myocardium, accurately modeling their arrangement is essential for simulating heart electrophysiology (EP). Rule-Based-Methods (RBMs) represent a commonly used…

Electrical analogy (Lumped method) is an easy way to model human cardiovascular system. In this paper Lumped method is used for simulating a complete model. It describes a 36-vessel model and cardiac system of human body with details that…

Medical Physics · Physics 2014-11-21 Omid Ghasemalizadeh , Mohammad Reza Mirzaee , Bahar Firoozabadi , Kamran Hassani