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Deep learning has shown remarkable results for image analysis and is expected to aid individual treatment decisions in health care. To achieve this, deep learning methods need to be promoted from the level of mere associations to being able…

Machine Learning · Computer Science 2022-05-02 Wouter A. C. van Amsterdam , Marinus J. C. Eijkemans

Tumor samples are heterogeneous. They consist of different subclones that are characterized by differences in DNA nucleotide sequences and copy numbers on multiple loci. Heterogeneity can be measured through the identification of the…

Methodology · Statistics 2014-09-26 Juhee Lee , Peter Mueller , Subhajit Sengupta , Kamalakar Gulukota , Yuan Ji

Melanoma is one of the ten most common cancers in the US. Early detection is crucial for survival, but often the cancer is diagnosed in the fatal stage. Deep learning has the potential to improve cancer detection rates, but its…

Computer Vision and Pattern Recognition · Computer Science 2019-05-16 Devansh Bisla , Anna Choromanska , Jennifer A. Stein , David Polsky , Russell Berman

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and the most common cause of death of people suffering from cirrhosis. The segmentation of liver lesions in CT images allows assessment of tumor load,…

Computer Vision and Pattern Recognition · Computer Science 2020-03-16 Nadja Gruber , Stephan Antholzer , Werner Jaschke , Christian Kremser , Markus Haltmeier

Several deep learning algorithms have been developed to predict survival of cancer patients using whole slide images (WSIs).However, identification of image phenotypes within the WSIs that are relevant to patient survival and disease…

Image and Video Processing · Electrical Eng. & Systems 2022-11-30 Xingyu Li , Jitendra Jonnagaddala , Min Cen , Hong Zhang , Xu Steven Xu

Mohs micrographic surgery (MMS) is the gold standard technique for removing high risk nonmelanoma skin cancer however, intraoperative histopathological examination demands significant time, effort, and professionality. The objective of this…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Abdurrahim Yilmaz , Serra Atilla Aydin , Deniz Temur , Furkan Yuceyalcin , Berkin Deniz Kahya , Rahmetullah Varol , Ozay Gokoz , Gulsum Gencoglan , Huseyin Uvet , Gonca Elcin

Objective: To report imaging protocol and scheduling variance in routine care of glioblastoma patients in order to demonstrate challenges of integrating deep-learning models in glioblastoma care pathways. Additionally, to understand the…

Skin cancer is the most common type of cancer. Specifically, melanoma is the cause of 75% of skin cancer deaths, although it is the least common skin cancer. Better detection of melanoma could have a positive impact on millions of people.…

Computer Vision and Pattern Recognition · Computer Science 2023-02-21 Chengdong Yao

Motivation: Tumor classification using Imaging Mass Spectrometry (IMS) data has a high potential for future applications in pathology. Due to the complexity and size of the data, automated feature extraction and classification steps are…

Machine Learning · Statistics 2018-06-28 Jens Behrmann , Christian Etmann , Tobias Boskamp , Rita Casadonte , Jörg Kriegsmann , Peter Maass

Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and…

Computer Vision and Pattern Recognition · Computer Science 2019-04-24 Spyridon Bakas , Mauricio Reyes , Andras Jakab , Stefan Bauer , Markus Rempfler , Alessandro Crimi , Russell Takeshi Shinohara , Christoph Berger , Sung Min Ha , Martin Rozycki , Marcel Prastawa , Esther Alberts , Jana Lipkova , John Freymann , Justin Kirby , Michel Bilello , Hassan Fathallah-Shaykh , Roland Wiest , Jan Kirschke , Benedikt Wiestler , Rivka Colen , Aikaterini Kotrotsou , Pamela Lamontagne , Daniel Marcus , Mikhail Milchenko , Arash Nazeri , Marc-Andre Weber , Abhishek Mahajan , Ujjwal Baid , Elizabeth Gerstner , Dongjin Kwon , Gagan Acharya , Manu Agarwal , Mahbubul Alam , Alberto Albiol , Antonio Albiol , Francisco J. Albiol , Varghese Alex , Nigel Allinson , Pedro H. A. Amorim , Abhijit Amrutkar , Ganesh Anand , Simon Andermatt , Tal Arbel , Pablo Arbelaez , Aaron Avery , Muneeza Azmat , Pranjal B. , W Bai , Subhashis Banerjee , Bill Barth , Thomas Batchelder , Kayhan Batmanghelich , Enzo Battistella , Andrew Beers , Mikhail Belyaev , Martin Bendszus , Eze Benson , Jose Bernal , Halandur Nagaraja Bharath , George Biros , Sotirios Bisdas , James Brown , Mariano Cabezas , Shilei Cao , Jorge M. Cardoso , Eric N Carver , Adrià Casamitjana , Laura Silvana Castillo , Marcel Catà , Philippe Cattin , Albert Cerigues , Vinicius S. Chagas , Siddhartha Chandra , Yi-Ju Chang , Shiyu Chang , Ken Chang , Joseph Chazalon , Shengcong Chen , Wei Chen , Jefferson W Chen , Zhaolin Chen , Kun Cheng , Ahana Roy Choudhury , Roger Chylla , Albert Clérigues , Steven Colleman , Ramiro German Rodriguez Colmeiro , Marc Combalia , Anthony Costa , Xiaomeng Cui , Zhenzhen Dai , Lutao Dai , Laura Alexandra Daza , Eric Deutsch , Changxing Ding , Chao Dong , Shidu Dong , Wojciech Dudzik , Zach Eaton-Rosen , Gary Egan , Guilherme Escudero , Théo Estienne , Richard Everson , Jonathan Fabrizio , Yong Fan , Longwei Fang , Xue Feng , Enzo Ferrante , Lucas Fidon , Martin Fischer , Andrew P. French , Naomi Fridman , Huan Fu , David Fuentes , Yaozong Gao , Evan Gates , David Gering , Amir Gholami , Willi Gierke , Ben Glocker , Mingming Gong , Sandra González-Villá , T. Grosges , Yuanfang Guan , Sheng Guo , Sudeep Gupta , Woo-Sup Han , Il Song Han , Konstantin Harmuth , Huiguang He , Aura Hernández-Sabaté , Evelyn Herrmann , Naveen Himthani , Winston Hsu , Cheyu Hsu , Xiaojun Hu , Xiaobin Hu , Yan Hu , Yifan Hu , Rui Hua , Teng-Yi Huang , Weilin Huang , Sabine Van Huffel , Quan Huo , Vivek HV , Khan M. Iftekharuddin , Fabian Isensee , Mobarakol Islam , Aaron S. Jackson , Sachin R. Jambawalikar , Andrew Jesson , Weijian Jian , Peter Jin , V Jeya Maria Jose , Alain Jungo , B Kainz , Konstantinos Kamnitsas , Po-Yu Kao , Ayush Karnawat , Thomas Kellermeier , Adel Kermi , Kurt Keutzer , Mohamed Tarek Khadir , Mahendra Khened , Philipp Kickingereder , Geena Kim , Nik King , Haley Knapp , Urspeter Knecht , Lisa Kohli , Deren Kong , Xiangmao Kong , Simon Koppers , Avinash Kori , Ganapathy Krishnamurthi , Egor Krivov , Piyush Kumar , Kaisar Kushibar , Dmitrii Lachinov , Tryphon Lambrou , Joon Lee , Chengen Lee , Yuehchou Lee , M Lee , Szidonia Lefkovits , Laszlo Lefkovits , James Levitt , Tengfei Li , Hongwei Li , Wenqi Li , Hongyang Li , Xiaochuan Li , Yuexiang Li , Heng Li , Zhenye Li , Xiaoyu Li , Zeju Li , XiaoGang Li , Wenqi Li , Zheng-Shen Lin , Fengming Lin , Pietro Lio , Chang Liu , Boqiang Liu , Xiang Liu , Mingyuan Liu , Ju Liu , Luyan Liu , Xavier Llado , Marc Moreno Lopez , Pablo Ribalta Lorenzo , Zhentai Lu , Lin Luo , Zhigang Luo , Jun Ma , Kai Ma , Thomas Mackie , Anant Madabushi , Issam Mahmoudi , Klaus H. Maier-Hein , Pradipta Maji , CP Mammen , Andreas Mang , B. S. Manjunath , Michal Marcinkiewicz , S McDonagh , Stephen McKenna , Richard McKinley , Miriam Mehl , Sachin Mehta , Raghav Mehta , Raphael Meier , Christoph Meinel , Dorit Merhof , Craig Meyer , Robert Miller , Sushmita Mitra , Aliasgar Moiyadi , David Molina-Garcia , Miguel A. B. Monteiro , Grzegorz Mrukwa , Andriy Myronenko , Jakub Nalepa , Thuyen Ngo , Dong Nie , Holly Ning , Chen Niu , Nicholas K Nuechterlein , Eric Oermann , Arlindo Oliveira , Diego D. C. Oliveira , Arnau Oliver , Alexander F. I. Osman , Yu-Nian Ou , Sebastien Ourselin , Nikos Paragios , Moo Sung Park , Brad Paschke , J. Gregory Pauloski , Kamlesh Pawar , Nick Pawlowski , Linmin Pei , Suting Peng , Silvio M. Pereira , Julian Perez-Beteta , Victor M. Perez-Garcia , Simon Pezold , Bao Pham , Ashish Phophalia , Gemma Piella , G. N. Pillai , Marie Piraud , Maxim Pisov , Anmol Popli , Michael P. Pound , Reza Pourreza , Prateek Prasanna , Vesna Prkovska , Tony P. Pridmore , Santi Puch , Élodie Puybareau , Buyue Qian , Xu Qiao , Martin Rajchl , Swapnil Rane , Michael Rebsamen , Hongliang Ren , Xuhua Ren , Karthik Revanuru , Mina Rezaei , Oliver Rippel , Luis Carlos Rivera , Charlotte Robert , Bruce Rosen , Daniel Rueckert , Mohammed Safwan , Mostafa Salem , Joaquim Salvi , Irina Sanchez , Irina Sánchez , Heitor M. Santos , Emmett Sartor , Dawid Schellingerhout , Klaudius Scheufele , Matthew R. Scott , Artur A. Scussel , Sara Sedlar , Juan Pablo Serrano-Rubio , N. Jon Shah , Nameetha Shah , Mazhar Shaikh , B. Uma Shankar , Zeina Shboul , Haipeng Shen , Dinggang Shen , Linlin Shen , Haocheng Shen , Varun Shenoy , Feng Shi , Hyung Eun Shin , Hai Shu , Diana Sima , M Sinclair , Orjan Smedby , James M. Snyder , Mohammadreza Soltaninejad , Guidong Song , Mehul Soni , Jean Stawiaski , Shashank Subramanian , Li Sun , Roger Sun , Jiawei Sun , Kay Sun , Yu Sun , Guoxia Sun , Shuang Sun , Yannick R Suter , Laszlo Szilagyi , Sanjay Talbar , Dacheng Tao , Dacheng Tao , Zhongzhao Teng , Siddhesh Thakur , Meenakshi H Thakur , Sameer Tharakan , Pallavi Tiwari , Guillaume Tochon , Tuan Tran , Yuhsiang M. Tsai , Kuan-Lun Tseng , Tran Anh Tuan , Vadim Turlapov , Nicholas Tustison , Maria Vakalopoulou , Sergi Valverde , Rami Vanguri , Evgeny Vasiliev , Jonathan Ventura , Luis Vera , Tom Vercauteren , C. A. Verrastro , Lasitha Vidyaratne , Veronica Vilaplana , Ajeet Vivekanandan , Guotai Wang , Qian Wang , Chiatse J. Wang , Weichung Wang , Duo Wang , Ruixuan Wang , Yuanyuan Wang , Chunliang Wang , Guotai Wang , Ning Wen , Xin Wen , Leon Weninger , Wolfgang Wick , Shaocheng Wu , Qiang Wu , Yihong Wu , Yong Xia , Yanwu Xu , Xiaowen Xu , Peiyuan Xu , Tsai-Ling Yang , Xiaoping Yang , Hao-Yu Yang , Junlin Yang , Haojin Yang , Guang Yang , Hongdou Yao , Xujiong Ye , Changchang Yin , Brett Young-Moxon , Jinhua Yu , Xiangyu Yue , Songtao Zhang , Angela Zhang , Kun Zhang , Xuejie Zhang , Lichi Zhang , Xiaoyue Zhang , Yazhuo Zhang , Lei Zhang , Jianguo Zhang , Xiang Zhang , Tianhao Zhang , Sicheng Zhao , Yu Zhao , Xiaomei Zhao , Liang Zhao , Yefeng Zheng , Liming Zhong , Chenhong Zhou , Xiaobing Zhou , Fan Zhou , Hongtu Zhu , Jin Zhu , Ying Zhuge , Weiwei Zong , Jayashree Kalpathy-Cramer , Keyvan Farahani , Christos Davatzikos , Koen van Leemput , Bjoern Menze

Computed tomography (CT) examinations are commonly used to predict lung nodule malignancy in patients, which are shown to improve noninvasive early diagnosis of lung cancer. It remains challenging for computational approaches to achieve…

Computer Vision and Pattern Recognition · Computer Science 2018-02-07 Jason Causey , Junyu Zhang , Shiqian Ma , Bo Jiang , Jake Qualls , David G. Politte , Fred Prior , Shuzhong Zhang , Xiuzhen Huang

Deep learning (DL) models for disease classification or segmentation from medical images are increasingly trained using transfer learning (TL) from unrelated natural world images. However, shortcomings and utility of TL for specialized…

Machine Learning · Statistics 2021-11-11 Sambuddha Ghosal , Pratik Shah

Most recently, the pathology diagnosis of cancer is shifting to integrating molecular makers with histology features. It is a urgent need for digital pathology methods to effectively integrate molecular markers with histology, which could…

Image and Video Processing · Electrical Eng. & Systems 2023-06-28 Xiaofei Wang , Stephen Price , Chao Li

Predicting outcomes, such as survival or metastasis for individual cancer patients is a crucial component of precision oncology. Machine learning (ML) offers a promising way to exploit rich multi-modal data, including clinical information…

Machine Learning · Computer Science 2021-06-04 Michal Kazmierski , Benjamin Haibe-Kains

We present a reproducible deep learning pipeline for leukemic cell classification, focusing on system architecture, experimental robustness, and software design choices for medical image analysis. Acute lymphoblastic leukemia (ALL) is the…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Douglas Costa Braga , Daniel Oliveira Dantas

Understanding how deep learning models predict oncology patient risk can provide critical insights into disease progression, support clinical decision-making, and pave the way for trustworthy and data-driven precision medicine. Building on…

Computer Vision and Pattern Recognition · Computer Science 2024-11-13 Marvin Sextro , Gabriel Dernbach , Kai Standvoss , Simon Schallenberg , Frederick Klauschen , Klaus-Robert Müller , Maximilian Alber , Lukas Ruff

Breast cancer is one of the most common types of cancer and leading cancer-related death causes for women. In the context of ICIAR 2018 Grand Challenge on Breast Cancer Histology Images, we compare one handcrafted feature extractor and five…

Computer Vision and Pattern Recognition · Computer Science 2018-04-02 Hongliu Cao , Simon Bernard , Laurent Heutte , Robert Sabourin

Relatively abundant availability of medical imaging data has provided significant support in the development and testing of Neural Network based image processing methods. Clinicians often face issues in selecting suitable image processing…

Image and Video Processing · Electrical Eng. & Systems 2021-09-10 Mayank Goswami

Cancer radiomics is an emerging discipline promising to elucidate lesion phenotypes and tumor heterogeneity through patterns of enhancement, texture, morphology, and shape. The prevailing technique for image texture analysis relies on the…

Applications · Statistics 2020-11-12 Xiao Li , Michele Guindani , Chaan S. Ng , Brian P. Hobbs

Complete removal of cancer tumors with a negative specimen margin during lumpectomy is essential in reducing breast cancer recurrence. However, 2D specimen radiography (SR), the current method used to assess intraoperative specimen margin…

Computer Vision and Pattern Recognition · Computer Science 2025-06-27 Tyler Ward , Xiaoqin Wang , Braxton McFarland , Md Atik Ahamed , Sahar Nozad , Talal Arshad , Hafsa Nebbache , Jin Chen , Abdullah Imran