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Multispectral photoacoustic (PA) imaging is a prime modality to monitor hemodynamics and changes in blood oxygenation (sO2). Although sO2 changes can be an indicator of brain activity both in normal and in pathological conditions, PA…

The reconstruction task in photoacoustic tomography can vary a lot depending on measured targets, geometry, and especially the quantity we want to recover. Specifically, as the signal is generated due to the coupling of light and sound by…

Medical Physics · Physics 2023-11-28 Andreas Hauptmann , Tanja Tarvainen

Laser enhanced field evaporation of surface atoms in Laser-assisted Atom Probe Tomography (La-APT) can simultaneously excite phtotoluminescence in semiconductor or insulating specimens. An atom probe equipped with appropriate focalization…

Photoacoustic tomography (PAT) enables non-invasive cross-sectional imaging of biological tissues, but it fails to map the spatial variation of speed-of-sound (SOS) within tissues. While SOS is intimately linked to density and elastic…

Medical Physics · Physics 2024-08-27 Yang Wang , Danni Wang , Liting Zhong , Yi Zhou , Qing Wang , Wufan Chen , Li Qi

We present a novel approach to achieve hyper spectral resolution, high sensitive detection, and high speed data acquisition Stimulated Raman Spectroscopy by employing amplified offset-phase controlled fs-pulse bursts. In this approach, the…

This paper presents a novel approach using multiple linear regression to process transient signals from silicon photomultipliers. The method provides excellent noise suppression and pulse detection in scenarios with a high pulse count rate…

Instrumentation and Detectors · Physics 2023-07-19 Wolfgang Schmailzl , Claudio Piemonte , Erika Garutti , Walter Hansch

The objective of image super-resolution is to reconstruct a high-resolution (HR) image with the prior knowledge from one or several low-resolution (LR) images. However, in the real world, due to the limited complementary information, the…

Image and Video Processing · Electrical Eng. & Systems 2024-12-16 Jing Sun , Qiangqiang Yuan , Huanfeng Shen , Jie Li , Liangpei Zhang

Spreading depolarization (SD) is a self-propagating wave of near-complete neuronal depolarization that is abundant in a wide range of neurological conditions, including stroke. SD was only recently documented in humans and is now considered…

Multi-photon microscopy has played a significant role in biological imaging since it allows to observe living tissues with improved penetration depth and excellent sectioning effect. Multi-photon microscopy relies on multi-photon…

By measuring the thermal effects resulting from stimulated Raman excitations, stimulated Raman photothermal (SRP) microscope offers a new access to spatially and temporally resolved Raman signatures across various sample types. Unlike…

Optics · Physics 2026-03-03 Yifan Zhu , Hongli Ni , Hongjian He , Yueming Li , Meng Zhang , Ji-Xin Cheng

Nonlinear optical processes are used in biological microscopy to surpass the diffraction limit on resolution, image deeper into brain tissues, and identify biomolecules without exogenous labels. These techniques typically require high…

Photo-acoustic spectroscopy (PAS) is one of the most sensitive non-destructive analysis techniques for gases, fluids and solids. It can operate background-free at any wavelength and is applicable to microscopic and even non-transparent…

In spectroscopic analysis, the peak-based signal-to-noise ratio (pSNR) is commonly used but suffers from limitations such as sensitivity to noise spikes and reduced effectiveness for broader peaks. We introduce the area-based…

Signal Processing · Electrical Eng. & Systems 2025-12-25 Alex Yu , Huaqing Zhao , Lin Z. Li

Photoacoustic computed tomography (PACT) is a hybrid imaging modality, which combines the high optical contrast of pure optical imaging and the high penetration depth of ultrasound imaging. However, photoacoustic image dataset with good…

Medical Physics · Physics 2022-05-24 Tengbo Lyu , Changchun Yang , Jiadong Zhang , Shanshan Guo , Feng Gao , Fei Gao

One primary technical challenge in photoacoustic microscopy (PAM) is the necessary compromise between spatial resolution and imaging speed. In this study, we propose a novel application of deep learning principles to reconstruct…

Image and Video Processing · Electrical Eng. & Systems 2020-06-02 Anthony DiSpirito , Daiwei Li , Tri Vu , Maomao Chen , Dong Zhang , Jianwen Luo , Roarke Horstmeyer , Junjie Yao

Photoacoustic imaging (PAI) is an emerging medical imaging modality capable of providing high spatial resolution of Ultrasound (US) imaging and high contrast of optical imaging. Delay-and-Sum (DAS) is the most common beamforming algorithm…

Signal Processing · Electrical Eng. & Systems 2018-01-24 Moein Mozaffarzadeh , Ali Mahloojifar , Mahdi Orooji , Saba Adabi , Mohammadreza Nasiriavanaki

In typical single-pixel detection multiplexing, an unknown object is sequentially illuminated with intensity patterns: the total signal is summed into a single-pixel detector and is then demultiplexed to retrieve the object. Because of…

Optics · Physics 2022-04-14 Camille Scotté , Frédéric Galland , Hervé Rigneault

Noise is an important factor that degrades the quality of medical images. Impulse noise is a common noise, which is caused by malfunctioning of sensor elements or errors in the transmission of images. In medical images due to presence of…

Computer Vision and Pattern Recognition · Computer Science 2017-10-13 Zohreh HosseinKhani , Mohsen Hajabdollahi , Nader Karimi , Reza Soroushmehr , Shahram Shirani , Kayvan Najarian , Shadrokh Samavi

Ultrasound plane wave imaging is a cutting-edge technique that enables high frame-rate imaging. However, one challenge associated with high frame-rate ultrasound imaging is the high noise associated with them, hindering their wider…

Image and Video Processing · Electrical Eng. & Systems 2024-08-21 Hojat Asgariandehkordi , Sobhan Goudarzi , Mostafa Sharifzadeh , Adrian Basarab , Hassan Rivaz

Photoacoustic imaging (PAI) has been applied to many biomedical applications over the past decades. However, the received PA signal usually suffers from poor signal-to-noise ratio (SNR). Conventional solution of employing higher-power…

Signal Processing · Electrical Eng. & Systems 2023-07-26 Xinke Li , Peng Ge , Yuting Shen , Feng Gao , Fei Gao