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This study proposes a novel, integrative framework for patient-centered data science in the digital health era. We developed a multidimensional model that combines traditional clinical data with patient-reported outcomes, social…

Machine Learning · Computer Science 2024-08-07 Mohsen Amoei , Dan Poenaru

Instance segmentation plays a pivotal role in medical image analysis by enabling precise localization and delineation of lesions, tumors, and anatomical structures. Although deep learning models such as Mask R-CNN and BlendMask have…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Mengxia Dai , Wenqian Luo , Tianyang Li

Many problems within personalized medicine and digital health rely on the analysis of continuous-time functional biomarkers and other complex data structures emerging from high-resolution patient monitoring. In this context, this work…

Machine Learning · Statistics 2025-01-14 Marcos Matabuena

There is no consensus in the field of synthetic data on concise metrics for quality evaluations or benchmarks on large health datasets, such as historical epidemiological data. This study presents an evaluation of seven recent models from…

Machine Learning · Computer Science 2026-04-20 Jean-Baptiste Escudié , Benjamin Barnes , Stefan Meisegeier , Klaus Kraywinkel , Fabian Prasser , Nils Körber

Synthetic data generation (SDG) is a promising approach for enabling data sharing in biomedical studies while preserving patient privacy. Yet, state-of-the-art generative models often require large datasets and complex training procedures,…

Machine Learning · Computer Science 2026-01-27 Natalia Espinosa-Dice , Nicholas J. Jackson , Chao Yan , Aaron Lee , Bradley A. Malin

Deep generative models and synthetic medical data have shown significant promise in addressing key challenges in healthcare, such as privacy concerns, data bias, and the scarcity of realistic datasets. While research in this area has grown…

Machine Learning · Computer Science 2025-02-05 Krishan Agyakari Raja Babu , Supriti Mulay , Om Prabhu , Mohanasankar Sivaprakasam

This paper discusses the latest generation of the MONARC (MOdels of Networked Analysis at Regional Centers) simulation framework, as a design and modelling tool for large scale distributed systems applied to HEP experiments. A…

Distributed, Parallel, and Cluster Computing · Computer Science 2011-06-28 Ciprian Dobre , Corina Stratan

The rise of In-Context Learning (ICL) for universal medical image segmentation has introduced an unprecedented demand for large-scale, diverse datasets for training, exacerbating the long-standing problem of data scarcity. While data…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Jiesi Hu , Yanwu Yang , Zhiyu Ye , Chenfei Ye , Hanyang Peng , Jianfeng Cao , Ting Ma

Synthetic data generation with Large Language Models (LLMs) has emerged as a promising solution in the medical domain to mitigate data scarcity and privacy constraints. However, existing approaches remain constrained by their derivative…

Artificial Intelligence · Computer Science 2026-01-07 Yunghwei Lai , Ziyue Wang , Weizhi Ma , Yang Liu

Synthetic health data have the potential to mitigate privacy concerns when sharing data to support biomedical research and the development of innovative healthcare applications. Modern approaches for data generation based on machine…

Machine Learning · Computer Science 2023-01-11 Chao Yan , Yao Yan , Zhiyu Wan , Ziqi Zhang , Larsson Omberg , Justin Guinney , Sean D. Mooney , Bradley A. Malin

Systems engineering approaches use high-level models to capture the architecture and behavior of the system. However, when safety engineers conduct safety and reliability analysis, they have to create formal models, such as fault-trees,…

Software Engineering · Computer Science 2020-04-29 Simon József Nagy , Bence Graics , Kristóf Marussy , András Vörös

Health monitoring systems have revolutionized modern healthcare by enabling the continuous capture of physiological and behavioral data, essential for preventive measures and early health intervention. While integrating this data with Large…

Machine Learning · Computer Science 2024-06-26 Ajan Subramanian , Zhongqi Yang , Iman Azimi , Amir M. Rahmani

Synthetic data is being used lately for training deep neural networks in computer vision applications such as object detection, object segmentation and 6D object pose estimation. Domain randomization hereby plays an important role in…

Computer Vision and Pattern Recognition · Computer Science 2024-05-13 Parth Rawal , Mrunal Sompura , Wolfgang Hintze

Stochastic simulation aims to compute output performance for complex models that lack analytical tractability. To ensure accurate prediction, the model needs to be calibrated and validated against real data. Conventional methods approach…

Methodology · Statistics 2021-05-28 Yuanlu Bai , Tucker Balch , Haoxian Chen , Danial Dervovic , Henry Lam , Svitlana Vyetrenko

The increasing use of Large Language Models (LLMs) offers significant opportunities across the engineering lifecycle, including requirements engineering, software development, process optimization, and decision support. Despite this…

Software Engineering · Computer Science 2026-02-05 Stefan Otten , Philipp Reis , Philipp Rigoll , Joshua Ransiek , Tobias Schürmann , Jacob Langner , Eric Sax

Synthetic data generation has emerged as an invaluable solution in scenarios where real-world data collection and usage are limited by cost and scarcity. Large language models (LLMs) have demonstrated remarkable capabilities in producing…

Machine Learning · Computer Science 2025-07-22 Anh Nguyen , Sam Schafft , Nicholas Hale , John Alfaro

Synthetic Electronic Health Records (EHRs) offer a valuable opportunity to create privacy preserving and harmonized structured data, supporting numerous applications in healthcare. Key benefits of synthetic data include precise control over…

Computation and Language · Computer Science 2025-04-28 Yihan Lin , Zhirong Bella Yu , Simon Lee

Functional data, i.e., smooth random functions observed over a continuous domain, are increasingly available in areas such as biomedical research, health informatics, and epidemiology. However, effective statistical analysis for functional…

Machine Learning · Statistics 2026-04-07 Jianbin Tan , Anru R. Zhang

The integration of multimodal Electronic Health Records (EHR) data has significantly improved clinical predictive capabilities. Leveraging clinical notes and multivariate time-series EHR, existing models often lack the medical context…

Artificial Intelligence · Computer Science 2024-02-13 Yinghao Zhu , Changyu Ren , Shiyun Xie , Shukai Liu , Hangyuan Ji , Zixiang Wang , Tao Sun , Long He , Zhoujun Li , Xi Zhu , Chengwei Pan

Computational psychiatry faces a fundamental trade-off: traditional reinforcement learning (RL) models offer interpretability but lack behavioral realism, while large language model (LLM) agents generate realistic behaviors but lack…

Artificial Intelligence · Computer Science 2026-03-06 Zuo Fei , Kezhi Wang , Xiaomin Chen , Yizhou Huang