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The utilization of health data for secondary purposes, such as research, sta-tistics, and development, has become increasingly significant in advancing healthcare systems. To foster the above, Finland has established a framework for the…

Computers and Society · Computer Science 2024-12-11 Hannu Vilpponen , Antti Piirainen , Miikka Kallberg , Tommi Mikkonen

The current literature regarding generation of complex, realistic synthetic tabular data, particularly for randomized controlled trials (RCTs), often ignores missing data. However, missing data are common in RCT data and often are not…

Other Statistics · Statistics 2025-12-02 Niki Z. Petrakos , Erica E. M. Moodie , Nicolas Savy

Nowadays, the use of synthetic data has gained popularity as a cost-efficient strategy for enhancing data augmentation for improving machine learning models performance as well as addressing concerns related to sensitive data privacy.…

Machine Learning · Computer Science 2025-10-27 Ioannis E. Livieris , Nikos Alimpertis , George Domalis , Dimitris Tsakalidis

Background: Clinical prediction models are increasingly used to inform healthcare decisions, but determining the minimum sample size for their development remains a critical and unresolved challenge. Inadequate sample sizes can lead to…

Machine Learning · Computer Science 2026-03-02 Diana Shamsutdinova , Felix Zimmer , Oyebayo Ridwan Olaniran , Sarah Markham , Daniel Stahl , Gordon Forbes , Ewan Carr

To harness the potential of advanced computing technologies, efficient (real time) analysis of large amounts of data is as essential as are front-line simulations. In order to optimise this process, experts need to be supported by…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-07-03 Jovana Knežević , Ralf-Peter Mundani , Ernst Rank

In this paper, we present a machine learning-based data generator framework tailored to aid researchers who utilize simulations to examine various physical systems or processes. High computational costs and the resulting limited data often…

Machine Learning · Computer Science 2023-05-17 Sabber Ahamed , Md Mesbah Uddin

Although many AI applications of interest require specialized multi-modal models, relevant data to train such models is inherently scarce or inaccessible. Filling these gaps with human annotators is prohibitively expensive, error-prone, and…

Artificial Intelligence · Computer Science 2026-04-01 Tim R. Davidson , Benoit Seguin , Enrico Bacis , Cesar Ilharco , Hamza Harkous

We present RKappa, a framework for the development and analysis of rule-based models within a mature, statistically empowered R environment. The infrastructure allows model editing, modification, parameter sampling, simulation, statistical…

Molecular Networks · Quantitative Biology 2014-12-16 Anatoly Sorokin , Oksana Sorokina , J. Douglas Armstrong

Constructing robust simulators is essential for asking "what if?" questions and guiding policy in critical domains like healthcare and logistics. However, existing methods often struggle, either failing to generalize beyond historical data…

Machine Learning · Computer Science 2025-06-12 Samuel Holt , Max Ruiz Luyten , Antonin Berthon , Mihaela van der Schaar

Advancements in foundation models have catalyzed research in Embodied AI to develop interactive agents capable of environmental reasoning and interaction. Developing such agents requires diverse, large-scale datasets. Prior frameworks…

Robotics · Computer Science 2026-02-10 Siddharth Singh , Ifrah Idrees , Abraham Dauhajre

In order to implement disease-specific interventions in young age groups, policy makers in low- and middle-income countries require timely and accurate estimates of age- and cause-specific child mortality. High quality data is not available…

Clinical machine learning models experience significantly degraded performance in datasets not seen during training, e.g., new hospitals or populations. Recent developments in domain generalization offer a promising solution to this problem…

Machine Learning · Computer Science 2021-04-16 Haoran Zhang , Natalie Dullerud , Laleh Seyyed-Kalantari , Quaid Morris , Shalmali Joshi , Marzyeh Ghassemi

Simulation is increasingly being used for generating large labelled datasets in many machine learning problems. Recent methods have focused on adjusting simulator parameters with the goal of maximising accuracy on a validation task, usually…

Computer Vision and Pattern Recognition · Computer Science 2020-08-20 Harkirat Singh Behl , Atılım Güneş Baydin , Ran Gal , Philip H. S. Torr , Vibhav Vineet

Modern computer vision systems increasingly encounter performance limitations in data-scarce domains, where collecting large-scale, high-quality labeled data is costly or impractical. While controllable diffusion models enable scalable…

Image and Video Processing · Electrical Eng. & Systems 2026-05-12 Yukang Shen

Establishing causality is a fundamental goal in fields like medicine and social sciences. While randomized controlled trials are the gold standard for causal inference, they are not always feasible or ethical. Observational studies can…

Statistics Theory · Mathematics 2024-12-03 Andrew Ying

In statistics, it is important to have realistic data sets available for a particular context to allow an appropriate and objective method comparison. For many use cases, benchmark data sets for method comparison are already available…

Applications · Statistics 2024-05-30 Maria Thurow , Ina Dormuth , Christina Sauer , Marc Ditzhaus , Markus Pauly

Access to individual-level health data is essential for gaining new insights and advancing science. In particular, modern methods based on artificial intelligence rely on the availability of and access to large datasets. In the health…

Simulations, although powerful in accurately replicating real-world systems, often remain inaccessible to non-technical users due to their complexity. Conversely, large language models (LLMs) provide intuitive, language-based interactions…

Computation and Language · Computer Science 2025-05-22 Jacob Kleiman , Kevin Frank , Joseph Voyles , Sindy Campagna

Understanding individual-level human mobility is critical for a wide range of applications. As such, real-world trajectory datasets provide valuable insights into actual movement behaviors and patterns of life but are often constrained by…

Software Engineering · Computer Science 2026-01-22 Hossein Amiri , Joon-Seok Kim , Hamdi Kavak , Andrew Crooks , Dieter Pfoser , Carola Wenk , Andreas Züfle

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang