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Hyperspectral imaging captures both spectral and spatial information from a sample. The near infrared (NIR, > 800 nm) is advantageous for biomedical imaging as it falls into the tissue transparency window but also contains vibrational…

Mid-infrared (mid-IR) spectroscopy offers unparalleled sensitivity for the detection of trace gases, solids and liquids, which is based on the existence of strong telltale vibrational bands in this part of the spectrum. It was shown more…

Optics · Physics 2016-08-29 Viktor O. Smolski , Honglei Yang , Jia Xu , Konstantin L. Vodopyanov

Ultrafast mid-infrared (MIR) imaging is a key enabling capability for monitoring transient thermal and plasma phenomena in scientific diagnostics and industrial safety. However, conventional cryogenic MIR cameras face a fundamental…

Mid-infrared (MIR) spectroscopy is a powerful technique employed for a variety of applications, including gas sensing, industrial inspection, astronomy, surveillance, and imaging. Thin-film narrowband interference filters, targeted to…

Current methods for diagnosing the progression of multiple types of cancer within patients rely on interpreting stained needle biopsies. This process is time-consuming and susceptible to error throughout the paraffinization, Hematoxylin and…

Image and Video Processing · Electrical Eng. & Systems 2022-04-19 Benjamin Paulson , Theodore Colwell , Natalia Bukowski , Joseph Weller , Andrew Crisler , John Cisler , Alexander Drobek , Alexander Neuwirth

Sensing with undetected photons has become a vibrant, application-driven research domain with a special focus on the mid-infrared (mid-IR) wavelength region. Since the mid-IR contains spectral bands with highly specific and strong molecular…

Mid-infrared (MIR) spectroscopy is widely recognized as a powerful, non-distractive method for chemical analysis. However, its utility is constrained by a micrometer-scale spatial resolution imposed by the long-wavelength MIR diffraction…

To meet the challenges of high-resolution molecular spectroscopy, increasingly sophisticated spectroscopic techniques were developed. For a long time FTIR and laser-based spectroscopies were used for these studies. The recent development of…

High-order edge-enhanced imaging enables precise feature localization and effective background suppression, offering a powerful tool for real-time recognition and high-contrast visualization. Extending this capability to the mid-infrared…

Optics · Physics 2026-05-14 Jixi Zhang , Kun Huang , Shina Liao , Zhuohang Wei , Jianan Fang , Heping Zeng

Increasing the sweep rate of mid-infrared (MIR) frequency-swept sources offers significant potential for various high-speed spectroscopy-based applications. While continuous-wave frequency-swept lasers have achieved sweep rates up to 1 MHz,…

The capture of transient optical waveforms is critical to reveal dynamical phenomena in various fields. However, fast and sensitive mid-infrared (MIR) measurements are typically limited by processing bandwidth and detection sensitivity of…

Optics · Physics 2026-05-26 Wen Zhang , Kun Huang , Xu Wang , Ben Sun , Jianan Fang , Yijing Li , Heping Zeng

Photothermal microscopy is an emerging tool for measuring light-matter interactions with single-molecule sensitivity. It is generally believed that the spectral acquisition speed in photothermal microscopy is limited by the slow thermal…

Chemical imaging based on mid-infrared (MIR) spectroscopic contrast is an important technique with a myriad of applications, including biomedical imaging and environmental monitoring. Current MIR cameras, however, lack in performance and…

Instrumentation and Detectors · Physics 2021-07-06 David Knez , Adam M. Hanninen , Richard C. Prince , Eric O. Potma , Dmitry A. Fishman

Fourier ptychographic microscopy (FPM) is a pivotal computational imaging technique that achieves phase and amplitude reconstruction with high resolution and wide field of view, using low numerical aperture objectives and LED array…

We demonstrate instrumentation and methods to enable fluorescence-detected photothermal infrared (F-PTIR) microscopy, then demonstrate the utility of F-PTIR to characterize the composition within phase-separated domains of model amorphous…

Optical photothermal microscopy is a powerful, emerging method that overcomes the diffraction limit in infrared hyperspectral imaging by utilizing a visible probe laser beam to detect local temperature-induced modulation at the visible…

Nonlinear interferometers allow for mid-infrared spectroscopy with near-infrared detection using correlated photons. Previous implementations have demonstrated a spectral resolution limited by spectrally selective detection. In our work, we…

Human exposure to Volatile Organic Compounds (VOCs) and their presence in indoor and working environments is recognized as a serious health risk, causing impairment of varying severity. Different detecting systems able to monitor VOCs are…

Mass Spectrometry (MS) is a largely used analytical technique in biology with applications such as the determination of molecule masses or the elucidation of structural data. Fourier Transform Ion Cyclotron Resonance MS is one…

Chemical Physics · Physics 2019-06-17 Laura Duciel , Afef Cherni , Marc-André Delsuc

We report a broadband long-wave infrared Fourier transform spectrometer with sensitivity exceeding that of previously reported direct-detection implementations. The system combines dual-comb spectroscopy with electro-optic sampling,…