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Recent methodological developments have introduced new black-box approaches to better estimate heterogeneous treatment effects; however, these methods fall short of providing interpretable characterizations of the underlying individuals who…

Methodology · Statistics 2025-08-19 Melody Huang , Tiffany M. Tang , Ana M. Kenney

Inferring causal relationships as directed acyclic graphs (DAGs) is an important but challenging problem. Differentiable Causal Discovery (DCD) is a promising approach to this problem, framing the search as a continuous optimization. But…

Machine Learning · Computer Science 2024-06-28 Achille Nazaret , Justin Hong , Elham Azizi , David Blei

Modern cancer -omics and pharmacological data hold great promise in precision cancer medicine for developing individualized patient treatments. However, high heterogeneity and noise in such data pose challenges for predicting the response…

Quantitative Methods · Quantitative Biology 2020-11-18 Xiao Li , Tiffany M. Tang , Xuewei Wang , Jean-Pierre A. Kocher , Bin Yu

Prediction of mortality in intensive care unit (ICU) patients typically relies on black box models (that are unacceptable for use in hospitals) or hand-tuned interpretable models (that might lead to the loss in performance). We aim to…

Machine Learning · Computer Science 2025-01-09 Chloe Qinyu Zhu , Muhang Tian , Lesia Semenova , Jiachang Liu , Jack Xu , Joseph Scarpa , Cynthia Rudin

The convergence behavior of Stochastic Gradient Descent (SGD) crucially depends on the stepsize configuration. When using a constant stepsize, the SGD iterates form a Markov chain, enjoying fast convergence during the initial transient…

Machine Learning · Computer Science 2024-12-17 Xiang Li , Qiaomin Xie

Time series causal discovery is essential for understanding dynamic systems, yet many existing methods remain sensitive to noise, non-stationarity, and sampling variability. We propose the Validated Consensus-Driven Framework (VCDF), a…

Machine Learning · Computer Science 2026-02-26 Gene Yu , Ce Guo , Wayne Luk

Recent advances in drug discovery have demonstrated that incorporating side information (e.g., chemical properties about drugs and genomic information about diseases) often greatly improves prediction performance. However, these side…

Machine Learning · Computer Science 2026-03-20 Sijian Fan , Liyan Xiong , Dayuan Wang , Guoshuai Cai , Ray Bai

This paper proposes a predefined-time (PDT) neurodynamic approach with time-varying coefficients for solving mixed variational inequality problems (MVIs). A class of first-order proximal neurodynamic models is developed to guarantee…

Optimization and Control · Mathematics 2026-05-13 Vajahat Karim Khan , Md. Kalimuddin Ahmad

Effective reinforcement learning (RL) for sepsis treatment depends on learning stable, clinically meaningful state representations from irregular ICU time series. While previous works have explored representation learning for this task, the…

Machine Learning · Computer Science 2025-12-29 Yue Gao

Dynamic Uncertain Causality Graph(DUCG) is a recently proposed model for diagnoses of complex systems. It performs well for industry system such as nuclear power plants, chemical system and spacecrafts. However, the variable state…

Artificial Intelligence · Computer Science 2021-06-29 Hao Nie , Qin Zhang

Context: The VISTA Variables in the Via Lactea (VVV) and its extension (VVVX) are near-infrared surveys mapping the Galactic bulge and adjacent disk. These data have enabled the discovery of numerous star clusters obscured by high and…

In biomedical Subgroup Discovery, practitioners are interested in discovering interpretable and homogeneous subgroups within a group of patients. In this paper, assuming that healthy subjects (i.e., controls) share common but irrelevant…

Machine Learning · Computer Science 2026-05-21 Robin Louiset , Edouard Duchesnay , Benoit Dufumier , Antoine Grigis , Pietro Gori

Stance detection seeks to identify the viewpoints of individuals either in favor or against a given target or a controversial topic. Current advanced neural models for stance detection typically employ fully parametric softmax classifiers.…

Machine Learning · Computer Science 2024-06-21 Yinghan Cheng , Qi Zhang , Chongyang Shi , Liang Xiao , Shufeng Hao , Liang Hu

The estimation of Conditional Average Treatment Effects (CATE) is crucial for understanding the heterogeneity of treatment effects in clinical trials. We evaluate the performance of common methods, including causal forests and various…

Methodology · Statistics 2024-07-12 Oshri Machluf , Tzviel Frostig , Gal Shoham , Tomer Milo , Elad Berkman , Raviv Pryluk

Identifying patient subgroups with different treatment responses is an important task to inform medical recommendations, guidelines, and the design of future clinical trials. Existing approaches for treatment effect estimation primarily…

Methodology · Statistics 2025-12-10 Vincent Jeanselme , Chang Ho Yoon , Fabian Falck , Brian Tom , Jessica Barrett

Clinical prediction models are increasingly used to support patient care, yet many deep learning-based approaches remain unstable, as their predictions can vary substantially when trained on different samples from the same population. Such…

Machine Learning · Computer Science 2026-02-13 Sara Matijevic , Christopher Yau

Traditional medicine typically applies one-size-fits-all treatment for the entire patient population whereas precision medicine develops tailored treatment schemes for different patient subgroups. The fact that some factors may be more…

Machine Learning · Computer Science 2018-01-29 Milad Zafar Nezhad , Dongxiao Zhu , Najibesadat Sadati , Kai Yang , Phillip Levy

Dynamic cerebral autoregulation, that is the transient response of cerebral blood flow to changes in arterial blood pressure, is currently assessed using a variety of different time series methods and data collection protocols. In the…

Quantitative Methods · Quantitative Biology 2017-05-16 Adam Mahdi , Dragana Nikolic , Anthony A. Birch , Mette S. Olufsen , Ronney B. Panerai , David M. Simpson , Stephen J. Payne

The synthetic control method estimates the causal effect by comparing the treated unit's outcomes to a weighted average of control units that closely match its pre-treatment outcomes, assuming the relationship between treated and control…

Methodology · Statistics 2026-01-07 Taehyeon Koo , Zijian Guo

Early diagnosis and assessment of repetitive subconcussive (rSC) brain injuries are crucial for early clinical intervention. Conventional methods, largely relying on slow fMRI, fail to capture millisecond-level early cortical dynamics,…

Neurons and Cognition · Quantitative Biology 2026-04-27 Jiajia Li , Zhenzhen Yu , Zhenghao Fu , Guozheng Xu , Jian Song
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