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Estimating heterogeneous treatment effects (HTEs) over time is crucial in many disciplines such as personalized medicine. For example, electronic health records are commonly collected over several time periods and then used to personalize…

Accurate prediction of medical conditions with straight past clinical evidence is a long-sought topic in the medical management and health insurance field. Although great progress has been made with machine learning algorithms, the medical…

Competing risk analysis considers event times due to multiple causes, or of more than one event types. Commonly used regression models for such data include 1) cause-specific hazards model, which focuses on modeling one type of event while…

Clinical prediction from structured electronic health records (EHRs) is challenging due to high dimensionality, heterogeneity, class imbalance, and distribution shift. While tabular in-context learning (TICL) and retrieval-augmented methods…

The application of data mining, machine learning and artificial intelligence techniques in the field of diagnostics is not a new concept, and these techniques have been very successfully applied in a variety of applications, especially in…

Deep neural Network (DNN) is becoming a focal point in Machine Learning research. Its application is penetrating into different fields and solving intricate and complex problems. DNN is now been applied in health image processing to detect…

In the realm of cancer treatment, summarizing adverse drug events (ADEs) reported by patients using prescribed drugs is crucial for enhancing pharmacovigilance practices and improving drug-related decision-making. While the volume and…

Complex or co-existing diseases are commonly treated using drug combinations, which can lead to higher risk of adverse side effects. The detection of polypharmacy side effects is usually done in Phase IV clinical trials, but there are still…

Estimating counterfactual outcomes over time has the potential to unlock personalized healthcare by assisting decision-makers to answer ''what-iF'' questions. Existing causal inference approaches typically consider regular, discrete-time…

Spontaneous reporting system databases are key resources for post-marketing surveillance, providing real-world evidence (RWE) on the adverse events (AEs) of regulated drugs or other medical products. Various statistical methods have been…

Security-sensitive applications that rely on Deep Neural Networks (DNNs) are vulnerable to small perturbations that are crafted to generate Adversarial Examples(AEs). The AEs are imperceptible to humans and cause DNN to misclassify them.…

Timely and accurate extraction of Adverse Drug Events (ADE) from biomedical literature is paramount for public safety, but involves slow and costly manual labor. We set out to improve drug safety monitoring (pharmacovigilance, PV) through…

Deep learning (DL) has shown great success in many human-related tasks, which has led to its adoption in many computer vision based applications, such as security surveillance systems, autonomous vehicles and healthcare. Such…

We present an operational component of a real-world patient triage system. Given a specific patient presentation, the system is able to assess the level of medical urgency and issue the most appropriate recommendation in terms of best point…

A Deep Neural Network (DNN) based algorithm is proposed for the detection and classification of faults in industrial plants. The proposed algorithm has the ability to classify faults, especially incipient faults that are difficult to detect…

Many diagnostic errors occur because clinicians cannot easily access relevant information in patient Electronic Health Records (EHRs). In this work we propose a method to use LLMs to identify pieces of evidence in patient EHR data that…

The emerging research shows that lncRNAs are associated with a series of complex human diseases. However, most of the existing methods have limitations in identifying nonlinear lncRNA-disease associations (LDAs), and it remains a huge…

While the emergence of large administrative claims data provides opportunities for research, their use remains limited by the lack of clinical annotations relevant to disease outcomes, such as recurrence in breast cancer (BC). Several…

The treatment planning process for patients with head and neck (H&N) cancer is regarded as one of the most complicated due to large target volume, multiple prescription dose levels, and many radiation-sensitive critical structures near the…

Improper health insurance payments resulting from fraud and upcoding result in tens of billions of dollars in excess health care costs annually in the United States, motivating machine learning researchers to build anomaly detection models…