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Effective control of biological systems can often be achieved through the control of a surprisingly small number of distinct variables. We bring clarity to such results using the formalism of Boolean dynamical networks, analyzing the…

Molecular Networks · Quantitative Biology 2021-09-13 Enrico Borriello , Bryan C. Daniels

This paper investigates the problem of decomposition with respect to outputs for Boolean control networks (BCNs). First, with the linear expression of BCNs and the matrix semi-tensor product, some algebraic equivalent conditions for the…

Optimization and Control · Mathematics 2014-07-09 Yunlei Zou , Jiandong Zhu

Methods of modeling cellular regulatory networks as diverse as differential equations and Boolean networks co-exist, however, without any closer correspondence to each other. With the example system of the fission yeast cell cycle control…

Molecular Networks · Quantitative Biology 2015-03-13 Maria Davidich , Stefan Bornholdt

Probabilistic Boolean Networks (PBNs) were introduced as a computational model for the study of complex dynamical systems, such as Gene Regulatory Networks (GRNs). Controllability in this context is the process of making strategic…

Machine Learning · Computer Science 2020-09-08 Georgios Papagiannis , Sotiris Moschoyiannis

An interrelationship between Game Theory and Control Theory is seeked. In this respect two aspects of this relationship are brought up. To establish the direct relationship Control Based Games and to establish the inverse relationship Game…

Optimization and Control · Mathematics 2020-06-22 Souma Mazumdar

In this paper we establish several results on approximate controllability of a semilinear wave equation by making use of a single multiplicative control. These results are then applied to discuss the exact controllability properties for the…

Optimization and Control · Mathematics 2019-01-16 Mohamed Ouzahra

A continuous semiflow is introduced for linear control systems with delays in the states and controls and bounded control range. The state includes the control functions. It is proved that there exists a unique chain control set which…

Optimization and Control · Mathematics 2025-08-19 Fritz Colonius

The study of network structure has uncovered signatures of the organization of complex systems. However, there is also a need to understand how to control them; for example, identifying strategies to revert a diseased cell to a healthy…

Molecular Networks · Quantitative Biology 2016-04-19 Alexander J. Gates , Luis M. Rocha

A reflection of our ultimate understanding of a complex system is our ability to control its behavior. Typically, control has multiple prerequisites: It requires an accurate map of the network that governs the interactions between the…

Systems and Control · Computer Science 2016-09-21 Yang-Yu Liu , Albert-Laszló Barabási

Logical models have been successfully used to describe regulatory and signaling networks without requiring quantitative data. However, existing data is insufficient to adequately define a unique model, rendering the parametrization of a…

Discrete Mathematics · Computer Science 2019-01-24 José E. R. Cury , Pedro T. Monteiro , Claudine Chaouiya

In this work we are interested in the modelling and control of opinion dynamics spreading on a time evolving network with scale-free asymptotic degree distribution. The mathematical model is formulated as a coupling of an opinion alignment…

Optimization and Control · Mathematics 2015-11-03 Giacomo Albi , Lorenzo Pareschi , Mattia Zanella

Boolean networks, first developed in the late 1960s as a tool for studying complex disordered dynamical systems, consist of nodes governed by Boolean functions whose evolution is entirely deterministic in that the state of the network at a…

Quantum Physics · Physics 2023-03-02 Ian T. Durham

Predictive control, which is based on a model of the system to compute the applied input optimizing the future system behavior, is by now widely used. If the nominal models are not given or are very uncertain, data-driven model predictive…

Systems and Control · Electrical Eng. & Systems 2023-03-09 Hoang Hai Nguyen , Maurice Friedel , Rolf Findeisen

This work establishes a general stochastic maximum principle for partially observed optimal control of semi-linear stochastic partial differential equations in a nonconvex control domain. The state evolves in a Hilbert space driven by a…

Optimization and Control · Mathematics 2025-04-22 Yanzhao Cao , Hongjiang Qian , George Yin

A general maximum principle is proved for optimal controls of abstract semilinear stochastic evolution equations. The control variable, as well as linear unbounded operators, acts in both drift and diffusion terms, and the control set need…

Optimization and Control · Mathematics 2013-12-30 Kai Du , Qingxin Meng

The study of network structural controllability focuses on the minimum number of driver nodes needed to control a whole network. Despite intensive studies on this topic, most of them consider static networks only. It is well-known, however,…

Physics and Society · Physics 2021-01-27 Rui Zhang , Xiaomeng Wang , Ming Cheng , Tao Jia

Boolean networks are special types of finite state time-discrete dynamical systems. A Boolean network can be described by a function from an n-dimensional vector space over the field of two elements to itself. A fundamental problem in…

Quantitative Methods · Quantitative Biology 2013-07-03 Yi Ming Zou

Controllability, a basic property of various networked systems, has gained profound theoretical applications in complex social, technological, biological, and brain networks. Yet, little attention has been given to the control trajectory…

Optimization and Control · Mathematics 2018-06-13 Aming Li , Long Wang , Frank Schweitzer

Control of a dynamical system without the knowledge of dynamics is an important and challenging task. Modern machine learning approaches, such as deep neural networks (DNNs), allow for the estimation of a dynamics model from control inputs…

Systems and Control · Electrical Eng. & Systems 2023-11-14 Suruchi Sharma , Volodymyr Makarenko , Gautam Kumar , Stas Tiomkin

Notwithstanding the usefulness of system dynamics in analyzing complex policy problems, policy design is far from straightforward and in many instances trial-and-error driven. To address this challenge, we propose to combine system dynamics…

Physics and Society · Physics 2017-11-15 Lukas Schoenenberger , Radu Tanase