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Having a sufficient quantity of quality data is a critical enabler of training effective machine learning models. Being able to effectively determine the adequacy of a dataset prior to training and evaluating a model's performance would be…

Machine Learning · Computer Science 2026-04-28 Arya Hatamian , Lionel Levine , Haniyeh Ehsani Oskouie , Majid Sarrafzadeh

Clinical prediction models must be developed using sufficiently large datasets to minimise overfitting and ensure robust predictive performance. Existing sample size calculations assume complete predictor data for all included participants,…

In biospectroscopy, suitably annotated and statistically independent samples (e. g. patients, batches, etc.) for classifier training and testing are scarce and costly. Learning curves show the model performance as function of the training…

Applications · Statistics 2015-05-05 Claudia Beleites , Ute Neugebauer , Thomas Bocklitz , Christoph Krafft , Jürgen Popp

Background: Clinical prediction models are increasingly used to inform healthcare decisions, but determining the minimum sample size for their development remains a critical and unresolved challenge. Inadequate sample sizes can lead to…

Machine Learning · Computer Science 2026-03-02 Diana Shamsutdinova , Felix Zimmer , Oyebayo Ridwan Olaniran , Sarah Markham , Daniel Stahl , Gordon Forbes , Ewan Carr

Knowing exactly how many data points need to be labeled to achieve a certain model performance is a hugely beneficial step towards reducing the overall budgets for annotation. It pertains to both active learning and traditional data…

Computation and Language · Computer Science 2023-07-04 Ernie Chang , Muhammad Hassan Rashid , Pin-Jie Lin , Changsheng Zhao , Vera Demberg , Yangyang Shi , Vikas Chandra

Aims: To propose a general sample size framework for developing or updating a clinical prediction model using any statistical or machine learning method, based on drawing samples from anticipated posterior distributions and targeting…

During the COVID-19 pandemic, a massive number of attempts on the predictions of the number of cases and the other future trends of this pandemic have been made. However, they fail to predict, in a reliable way, the medium and long term…

Machine Learning · Computer Science 2020-11-30 Mert Nakıp , Onur Çopur , Cüneyt Güzeliş

When developing a clinical prediction model, the sample size of the development dataset is a key consideration. Small sample sizes lead to greater concerns of overfitting, instability, poor performance and lack of fairness. Previous…

The problem tackled in this paper is the determination of sample size for a given level and power in the context of a simple linear regression model. At a technical level, the simple linear regression model is a five-parameter model. It is…

Methodology · Statistics 2019-07-25 Tianyuan Guan , M. Khorshed Alam , M. Bhaskara Rao

A significant hurdle for analyzing large sample data is the lack of effective statistical computing and inference methods. An emerging powerful approach for analyzing large sample data is subsampling, by which one takes a random subsample…

Methodology · Statistics 2015-11-24 Rong Zhu , Ping Ma , Michael W. Mahoney , Bin Yu

In regression with random design, we study the problem of selecting a model that performs well for out-of-sample prediction. We do not assume that any of the candidate models under consideration are correct. Our analysis is based on…

Methodology · Statistics 2008-10-24 Hannes Leeb

We consider the problem of evaluating representations of data for use in solving a downstream task. We propose to measure the quality of a representation by the complexity of learning a predictor on top of the representation that achieves…

Machine Learning · Computer Science 2021-02-08 William F. Whitney , Min Jae Song , David Brandfonbrener , Jaan Altosaar , Kyunghyun Cho

Clinical prediction models are estimated using a sample of limited size from the target population, leading to uncertainty in predictions, even when the model is correctly specified. Generally, not all patient profiles are observed…

Methodology · Statistics 2024-02-09 Doranne Thomassen , Saskia le Cessie , Hans van Houwelingen , Ewout Steyerberg

In statistics and machine learning, logistic regression is a widely-used supervised learning technique primarily employed for binary classification tasks. When the number of observations greatly exceeds the number of predictor variables, we…

Machine Learning · Statistics 2024-04-02 Agniva Chowdhury , Pradeep Ramuhalli

Over the last few decades, prediction models have become a fundamental tool in statistics, chemometrics, and related fields. However, to ensure that such models have high value, the inferences that they generate must be reliable. In this…

When prospectively developing a new clinical prediction model (CPM), fixed sample size calculations are typically conducted before data collection based on sensible assumptions. But if the assumptions are inaccurate the actual sample size…

Large-sample data became prevalent as data acquisition became cheaper and easier. While a large sample size has theoretical advantages for many statistical methods, it presents computational challenges. Sketching, or compression, is a…

Machine Learning · Statistics 2020-05-11 Alexander F. Lapanowski , Irina Gaynanova

Data imbalance is common in production data, where controlled production settings require data to fall within a narrow range of variation and data are collected with quality assessment in mind, rather than data analytic insights. This…

Machine Learning · Statistics 2021-12-17 Rune D. Kjærsgaard , Manja G. Grønberg , Line K. H. Clemmensen

In clinical settings, we often face the challenge of building prediction models based on small observational data sets. For example, such a data set might be from a medical center in a multi-center study. Differences between centers might…

The commonly cited rule of thumb for regression analysis, which suggests that a sample size of $n \geq 30$ is sufficient to ensure valid inferences, is frequently referenced but rarely scrutinized. This research note evaluates the lower…

Methodology · Statistics 2024-10-17 David Randahl
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