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Cryo-electron microscopy (cryo-EM) is capable of producing reconstructed 3D images of biomolecules at near-atomic resolution. As such, it represents one of the most promising imaging techniques in structural biology. However, raw cryo-EM…

Quantitative Methods · Quantitative Biology 2021-05-25 Nina Miolane , Frédéric Poitevin , Yee-Ting Li , Susan Holmes

Generating images via the generative adversarial network (GAN) has attracted much attention recently. However, most of the existing GAN-based methods can only produce low-resolution images of limited quality. Directly generating…

Computer Vision and Pattern Recognition · Computer Science 2019-04-01 Yong Guo , Qi Chen , Jian Chen , Qingyao Wu , Qinfeng Shi , Mingkui Tan

In recent years, research on image generation methods has been developing fast. The auto-encoding variational Bayes method (VAEs) was proposed in 2013, which uses variational inference to learn a latent space from the image database and…

Computer Vision and Pattern Recognition · Computer Science 2018-07-12 Guoqiang Zhong , Wei Gao , Yongbin Liu , Youzhao Yang

Microscopy images often suffer from high levels of noise, which can hinder further analysis and interpretation. Content-aware image restoration (CARE) methods have been proposed to address this issue, but they often require large amounts of…

Image and Video Processing · Electrical Eng. & Systems 2023-03-30 Felix Fuentes-Hurtado , Jean-Baptiste Sibarita , Virgile Viasnoff

Cryo-electron microscopy (cryo-EM) enables single-particle analysis of biological macromolecules under strict low-dose imaging conditions, but the resulting micrographs often exhibit extremely low signal-to-noise ratios and weak particle…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Xiaoqi Wu , Xueying Zhan , Wen Li , Junhao Wu , Xin Huang , Min Xu

Image denoising plays a critical role in biomedical and microscopy imaging, especially when acquiring wide-field fluorescence-stained images. This task faces challenges in multiple fronts, including limitations in image acquisition…

Image and Video Processing · Electrical Eng. & Systems 2026-05-26 Qijun Yang , Yating Huang , Lintao Xiang , Hujun Yin

In this work, a denoising Cycle-GAN (Cycle Consistent Generative Adversarial Network) is implemented to yield high-field, high resolution, high signal-to-noise ratio (SNR) Magnetic Resonance Imaging (MRI) images from simulated low-field,…

Image and Video Processing · Electrical Eng. & Systems 2023-07-14 Fernando Vega , Abdoljalil Addeh , M. Ethan MacDonald

Foundation models in computer vision have demonstrated exceptional performance in zero-shot and few-shot tasks by extracting multi-purpose features from large-scale datasets through self-supervised pre-training methods. However, these…

Computer Vision and Pattern Recognition · Computer Science 2024-10-29 Yingjun Shen , Haizhao Dai , Qihe Chen , Yan Zeng , Jiakai Zhang , Yuan Pei , Jingyi Yu

Generative adversarial networks (GANs) are neural networks that learn data distributions through adversarial training. In intensive studies, recent GANs have shown promising results for reproducing training images. However, in spite of…

Computer Vision and Pattern Recognition · Computer Science 2020-04-01 Takuhiro Kaneko , Tatsuya Harada

Cryo-electron microscopy (cryo-EM) has achieved near-atomic level resolution of biomolecules by reconstructing 2D micrographs. However, the resolution and accuracy of the reconstructed particles are significantly reduced due to the…

Computer Vision and Pattern Recognition · Computer Science 2024-01-03 Jing Zhang , Tengfei Zhao , ShiYu Hu , Xin Zhao

Many imaging modalities involve reconstruction of unknown objects from collections of noisy projections related by random rotations. In one of these modalities, cryogenic electron microscopy (cryo-EM), the extremely low signal-to-noise…

Image and Video Processing · Electrical Eng. & Systems 2025-10-16 Joakim Andén , Justus Sagemüller

This paper proposes a deep learning-based denoising method for noisy low-dose computerized tomography (CT) images in the absence of paired training data. The proposed method uses a fidelity-embedded generative adversarial network (GAN) to…

Computer Vision and Pattern Recognition · Computer Science 2019-08-13 Hyoung Suk Park , Jineon Baek , Sun Kyoung You , Jae Kyu Choi , Jin Keun Seo

Multiple approaches to use deep learning for image restoration have recently been proposed. Training such approaches requires well registered pairs of high and low quality images. While this is easily achievable for many imaging modalities,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Tim-Oliver Buchholz , Mareike Jordan , Gaia Pigino , Florian Jug

A deep convolutional neural network has been developed to denoise atomic-resolution TEM image datasets of nanoparticles acquired using direct electron counting detectors, for applications where the image signal is severely limited by shot…

Generative Adversarial Networks (GAN) are known to produce synthetic data that are difficult to discern from real ones by humans. In this paper we present an approach to use GAN to produce realistically looking ECG signals. We utilize them…

Machine Learning · Computer Science 2020-09-08 Karol Antczak

In the past decade, deep conditional generative models have revolutionized the generation of realistic images, extending their application from entertainment to scientific domains. Single-particle cryo-electron microscopy (cryo-EM) is…

Computer Vision and Pattern Recognition · Computer Science 2024-10-01 Jiakai Zhang , Qihe Chen , Yan Zeng , Wenyuan Gao , Xuming He , Zhijie Liu , Jingyi Yu

Generative adversarial networks (GANs) transform low-dimensional latent vectors into visually plausible images. If the real dataset contains only clean images, then ostensibly, the manifold learned by the GAN should contain only clean…

Computer Vision and Pattern Recognition · Computer Science 2018-03-14 Subarna Tripathi , Zachary C. Lipton , Truong Q. Nguyen

Generative Adversarial Networks (GANs) have surfaced as a revolutionary element within the domain of low-dose computed tomography (LDCT) imaging, providing an advanced resolution to the enduring issue of reconciling radiation exposure with…

Image and Video Processing · Electrical Eng. & Systems 2025-02-05 Yunuo Wang , Ningning Yang , Jialin Li

Generative Adversarial Networks (GANs) are considered the state-of-the-art in the field of image generation. They learn the joint distribution of the training data and attempt to generate new data samples in high dimensional space following…

Computer Vision and Pattern Recognition · Computer Science 2020-04-29 Sherif Abdulatif , Karim Armanious , Fady Aziz , Urs Schneider , Bin Yang

We tackle a challenging blind image denoising problem, in which only single distinct noisy images are available for training a denoiser, and no information about noise is known, except for it being zero-mean, additive, and independent of…

Image and Video Processing · Electrical Eng. & Systems 2021-07-06 Sungmin Cha , Taeeon Park , Byeongjoon Kim , Jongduk Baek , Taesup Moon
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