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Optical coherence tomography (OCT) is a powerful and noninvasive method for retinal imaging. In this paper, we introduce a fast segmentation method based on a new variant of spectral graph theory named diffusion maps. The research is…

Computer Vision and Pattern Recognition · Computer Science 2012-10-09 Raheleh Kafieh , Hossein Rabbani , Michael D. Abramoff , Milan Sonka

Dynamic optical coherence tomography (DOCT) statistically analyzes fluctuations in time-sequential OCT signals, enabling label-free and three-dimensional visualization of intratissue and intracellular activities. Current DOCT methods, such…

Cells alter the path of light, a fact that leads to well-known aberrations in single cell or tissue imaging. Optical diffraction tomography (ODT) measures the biophysical property that causes these aberrations, the refractive index (RI).…

Quantitative Methods · Quantitative Biology 2017-08-14 Mirjam Schürmann , Gheorghe Cojoc , Salvatore Girardo , Elke Ulbricht , Jochen Guck , Paul Müller

A broad class of imaging modalities involve the resolution of an inverse-scattering problem. Among them, three-dimensional optical diffraction tomography (ODT) comes with its own challenges. These include a limited range of views, a large…

Image and Video Processing · Electrical Eng. & Systems 2020-04-20 Thanh-an Pham , Emmanuel Soubies , Ahmed Ayoub , Joowon Lim , Demetri Psaltis , Michael Unser

Spectral domain optical coherence tomography (OCT) offers high resolution multidimensional imaging, but generally suffers from defocussing, intensity falloff and shot noise, causing artifacts and image degradation along the imaging depth.…

Image and Video Processing · Electrical Eng. & Systems 2021-08-04 Jonathan H. Mason , Yvonne Reinwald , Ying Yang , Sarah Waters , Alicia El Haj , Pierre O. Bagnaninchi

Optical coherence tomography (OCT) is a 3D imaging technique that was introduced in 1991 [Science 254, 1178 (1991); Applied Optics 31, 919 (1992)]. Since 2018 there has been growing interest in a new type of OCT scheme based on the use of…

Optical coherence tomography (OCT) is a prevalent, interferometric, high-resolution imaging method with broad biomedical applications. Nonetheless, OCT images suffer from an artifact, called speckle which degrades the image quality. Digital…

Optical coherence tomography (OCT) is a powerful technology for rapid volumetric imaging in biomedicine. The bright field imaging approach of conventional OCT systems is based on the detection of directly backscattered light, thereby…

Non-contact measurement of the refractive index and thickness of multilayer biological tissues is of great significance for biomedical applications and can greatly improve medical diagnosis and treatment. In this work, we introduce a…

Optics · Physics 2024-04-19 Yu-Lin Ku , Yao-Gen Shu

In optical diffraction tomography (ODT), a sample's 3D refractive-index (RI) is often reconstructed after illuminating it from multiple angles, with the assumption that the sample remains static throughout data collection. When the sample…

Optics · Physics 2024-12-13 Jeongsoo Kim , Shwetadwip Chowdhury

Optical coherence Doppler tomography (ODT) is an emerging blood flow imaging technique. The fundamental unit of ODT is the 1D depth-resolved trace named raw A-scans (or A-line). A 2D ODT image (B-scan) is formed by reconstructing a…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Zhenghong Li , Jiaxiang Ren , Wensheng Cheng , Yanzuo Liu , Congwu Du , Yingtian Pan , Haibin Ling

We show that structural information can be extracted from single molecule localization microscopy (SMLM) data. More precisely, we reinterpret SMLM data as the measures of a phaseless optical diffraction tomography system for which the…

Signal Processing · Electrical Eng. & Systems 2023-07-19 Thanh-An Pham , Emmanuel Soubies , Ferréol Soulez , Michael Unser

In this chapter a general mathematical model of Optical Coherence Tomography (OCT) is presented on the basis of the electromagnetic theory. OCT produces high resolution images of the inner structure of biological tissues. Images are…

Numerical Analysis · Mathematics 2016-04-19 Peter Elbau , Leonidas Mindrinos , Otmar Scherzer

Optoacoustic tomography (OAT), also known as photoacoustic tomography, is a rapidly emerging hybrid imaging technique that possesses great potential for a wide range of biomedical imaging applications. In OAT, a laser is employed to…

Medical Physics · Physics 2016-12-21 Yang Lou , Kun Wang , Alexander. A. Oraevsky , Mark. A. Anastasio

We report a time-domain optical coherence tomography (TD-OCT) system operating in the 2 $\mu\mathrm{m}$ spectral region, enabled by a GaSb-based superluminescent diode (SLD). The spectrum emitted by the SLD exhibits a full-width…

Full-field optical coherence tomography (FF-OCT) offers label-free, high-resolution imaging of biological samples but remains limited by slow acquisition due to piezoelectric mirror modulation. We present a continuous-scanning FF-OCT method…

Optics · Physics 2025-09-11 Charlie Kersuzan , Anirban Jana , Amaury Badon

We introduce a novel interferometric approach for suppressing zero-order diffraction (ZOD) in phase-only computer-generated holography. The technique relies on the destructive interference between the zeroth-order light and a suppression…

This paper reports on advances in optical coherence tomography (OCT) for application in dermatology. Full-field OCT is a particular approach of OCT based on white-light interference microscopy. FF-OCT produces en face tomographic images by…

Medical Physics · Physics 2018-04-06 Olivier Levecq , Arthur Davis , Hicham Azimani , David Siret , Jean-Luc Perrot , Arnaud Dubois

Optical coherence tomography (OCT) image analysis plays an important role in the field of ophthalmology. Current successful analysis models rely on available large datasets, which can be challenging to be obtained for certain tasks. The use…

Image and Video Processing · Electrical Eng. & Systems 2024-05-28 Kun Huang , Xiao Ma , Yuhan Zhang , Na Su , Songtao Yuan , Yong Liu , Qiang Chen , Huazhu Fu

Two-photon photopolymerization (TPP) has recently become a popular method for the fabrication of three-dimensional (3D) micro- and nanostructures. The reproduction fidelity of the designed micro- and nanostructures is influenced by…

Optics · Physics 2022-07-12 Yanping He , Qi Shao , Shih-chi Chen , Renjie Zhou