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Boron Neutron Capture Therapy (BNCT) is a form of radiotherapy based on the irradiation of the tumour with a low energy neutron beam, after the administration of a selective drug enriched in boron-10. The therapy exploits the high cross…

Background and purpose: Accelerator-Based Boron Neutron Capture Therapy is a radiotherapy based on compact accelerator neutron sources requiring an epithermal neutron field for tumour irradiations. Neutrons of 10 keV are considered as the…

Medical Physics · Physics 2021-02-05 Marine Hervé , Nadine Sauzet , Daniel Santos

Boron Neutron Capture Therapy (BNCT) is an innovative binary form of radiation therapy with high selectivity towards cancer tissue based on the neutron capture reaction 10B(n,$\alpha$)7Li, consisting in the exposition of patients to neutron…

Bremsstrahlung photon beams produced by medical linear accelerators are currently the most commonly used method of radiation therapy for cancerous tumors. Photons with energies greater than 8-10 MeV potentially generate neutrons through…

Accelerator Physics · Physics 2013-07-11 Danial Salehi , M. Salehi Jozani , Dariush Sardari

Boron Neutron Capture Therapy (BNCT), is an advanced cancer therapy that destroys the cancer tumors using the well-known Li(p,n)Be . Because of the highly selectively reaction between a boron and a neutron, BNCT is effective for rapidly…

Accelerator Physics · Physics 2016-09-21 Zhu Xiaowen , Lu Yuanrong , Zhu Kun

Selective accumulation of B-10 compound in tumour tissue is a fundamental condition for the achievement of BNCT (Boron Neutron Capture Therapy), since the effectiveness of therapy irradiation derives just from neutron capture reaction of…

Medical Physics · Physics 2007-12-05 M. Cortesi

The accurate imaging and quantitative measurement of 478-keV prompt gamma rays are critical for advancing boron neutron capture therapy (BNCT), a promising cancer treatment. Although numerical simulations have indicated that such…

Instrumentation and Detectors · Physics 2025-09-03 Tetsuya Mizumoto , Shotaro Komura , Atsushi Takada , Yoshinori Sakurai , Toru Tanimori

The $^{10}$B isotope has been almost exclusively used in the neutron-capture radiation therapy (NCT) of cancer for decades. We have identified two other nuclides suitable for the radiotherapy, which have ca.10 times larger cross section of…

Medical Physics · Physics 2019-07-16 V. I. Kukulin , A. V. Bibikov , E. V. Tkalya , M. Ceccarelli , I. V. Bodrenko

Boron neutron capture therapy (BNCT) leverages the nuclear reaction between thermal neutrons and boron-10 (B-10) atoms to induce selective tumor cell death. The spatial and quantum mechanical overlap between the neutron wavefunction and…

Chemical Physics · Physics 2025-10-20 Hung-Te Henry Su , Chih-Hsueh Lin , Po-Han Lee

This work presents a preliminary evaluation of the use of the convolutional neural network nnU-NET to automatically contour the volume of Glioblastoma Multiforme in medical images of patients. The goal is to assist the preparation of the…

Boron neutron capture therapy is about a century old, but still current and active. In this treatment, a high absorption cross-section of boron is used for thermal neutrons and the excited state is decomposed into alpha and lithium ions.…

Accelerator Physics · Physics 2025-04-24 H. Donya , M. Umer

Beam monitoring and evaluation are very important to boron neutron capture therapy (BNCT), and a variety of detectors have been developed for these applications. However, most of the detectors used in BNCT only have a small detection area,…

Instrumentation and Detectors · Physics 2023-06-14 Zhujun Fang , Zhiyong Zhang , Bin Shi , Wei Jiang , Xianke Liu , Siqi He , Jun Chen , Ping Cao , Jianbei Liu , Yi Zhou , Ming Shao , Botian Qu , Shufeng Zhang , Qian Wang

We propose a series of simulations about the potential use of Boron isotopes to trigger neutron-free (aneutronic) nuclear reactions in cancer cells through the interaction with an incoming energetic proton beam, thus resulting in the…

Medical Physics · Physics 2016-08-25 L. Giuffrida , D. Margarone , G. A. P. Cirrone , A. Picciotto , G. Korn

Protontherapy is hadrontherapy fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct…

Dosimetry in BNCT poses significant challenges due to the indirect effect of neutrons interacting with elements within the body and uncertainties associated with the uptake of boron compounds used in clinical practice. Current treatment…

The HANARO ex-core neutron irradiation facility was developed for various applications in the boron neutron capture therapy (BNCT) field, and its characteristics have been investigated. In order to obtain a sufficient thermal neutron flux…

Medical Physics · Physics 2015-06-26 Myong-Seop Kim , Byung-Chul Lee , Sung-Yul Hwang , Heonil Kim , Byung-Jin Jun

Hadrontherapy is a novel technique of cancer radiation therapy which employs beams of charged hadrons, protons and carbon ions in particular. Due to their physical and radiobiological properties, they allow one to obtain a more conformal…

Medical Physics · Physics 2015-05-14 Saverio Braccini

Radiotherapy is one of the main methods in the successful treatment of cancer. The tumor is irradiated with photons or charged particles (e.g. protons), and in the case of massive charged particles, the treatment results in less unnecessary…

Medical Physics · Physics 2019-03-20 Monika Varga-Kofarago

This paper explores the adaptation and application of i-TED Compton imagers for real-time dosimetry in Boron Neutron Capture Therapy (BNCT). The i-TED array, previously utilized in nuclear astrophysics experiments at CERN, is being…

The question of whether or not neutron therapy works has been answered. It is a qualified yes, as is the case with all of radiation therapy. But, neutron therapy has not kept pace with the rest of radiation therapy in terms of beam delivery…

Medical Physics · Physics 2014-09-09 Thomas K. Kroc , James S. Welsh
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