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Cryo-Electron Tomography (cryo-ET) is a 3D imaging technology that enables the visualization of subcellular structures in situ at near-atomic resolution. Cellular cryo-ET images help in resolving the structures of macromolecules and…

Quantitative Methods · Quantitative Biology 2021-11-18 Hmrishav Bandyopadhyay , Zihao Deng , Leiting Ding , Sinuo Liu , Mostofa Rafid Uddin , Xiangrui Zeng , Sima Behpour , Min Xu

Motivation: Cryo-Electron Tomography (cryo-ET) is a 3D bioimaging tool that visualizes the structural and spatial organization of macromolecules at a near-native state in single cells, which has broad applications in life science. However,…

Quantitative Methods · Quantitative Biology 2021-07-28 Xuefeng Du , Haohan Wang , Zhenxi Zhu , Xiangrui Zeng , Yi-Wei Chang , Jing Zhang , Min Xu

Motivation: Cellular Electron CryoTomography (CECT) enables 3D visualization of cellular organization at near-native state and in sub-molecular resolution, making it a powerful tool for analyzing structures of macromolecular complexes and…

Quantitative Methods · Quantitative Biology 2017-04-14 Min Xu , Xiaoqi Chai , Hariank Muthakana , Xiaodan Liang , Ge Yang , Tzviya Zeev-Ben-Mordehai , Eric Xing

Cryo-electron tomography (cryo-ET) is an imaging technique that allows three-dimensional visualization of macro-molecular assemblies under near-native conditions. Cryo-ET comes with a number of challenges, mainly low signal-to-noise and…

Cellular Electron Cryo-Tomography (CECT) is a powerful imaging technique for the 3D visualization of cellular structure and organization at submolecular resolution. It enables analyzing the native structures of macromolecular complexes and…

Quantitative Methods · Quantitative Biology 2018-05-16 Chang Liu , Xiangrui Zeng , Ruogu Lin , Xiaodan Liang , Zachary Freyberg , Eric Xing , Min Xu

Accurate segmentation of electron microscopy (EM) volumes of the brain is essential to characterize neuronal structures at a cell or organelle level. While supervised deep learning methods have led to major breakthroughs in that direction…

Computer Vision and Pattern Recognition · Computer Science 2022-07-06 Daniel Franco-Barranco , Julio Pastor-Tronch , Aitor Gonzalez-Marfil , Arrate Muñoz-Barrutia , Ignacio Arganda-Carreras

Cryo-electron tomography (cryo-ET) has emerged as a powerful technique for imaging macromolecular complexes in their near-native states. However, the localization of 3D particles in cellular environments still presents a significant…

Computer Vision and Pattern Recognition · Computer Science 2025-05-27 Gokul Adethya , Bhanu Pratyush Mantha , Tianyang Wang , Xingjian Li , Min Xu

Cryo-electron tomography (Cryo-ET) is a 3D imaging technique that enables the systemic study of shape, abundance, and distribution of macromolecular structures in single cells in near-atomic resolution. However, the systematic and efficient…

Biomolecules · Quantitative Biology 2021-06-29 Kai Yi , Jianye Pang , Yungeng Zhang , Xiangrui Zeng , Min Xu

Cryo-Electron Tomography (cryo-ET) is a 3D imaging technology facilitating the study of macromolecular structures at near-atomic resolution. Recent volumetric segmentation approaches on cryo-ET images have drawn widespread interest in…

Computer Vision and Pattern Recognition · Computer Science 2024-07-02 Haoran Li , Xingjian Li , Jiahua Shi , Huaming Chen , Bo Du , Daisuke Kihara , Johan Barthelemy , Jun Shen , Min Xu

Cryo-electron tomography (cryo-ET) enables in situ visualization of macromolecular structures, where subtomogram analysis tasks such as classification, alignment, and averaging are critical for structural determination. However, effective…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Runmin Jiang , Wanyue Feng , Yuntian Yang , Shriya Pingulkar , Hong Wang , Xi Xiao , Xiaoyu Cao , Genpei Zhang , Xiao Wang , Xiaolong Wu , Tianyang Wang , Yang Liu , Xingjian Li , Min Xu

Cellular Electron Cryo-Tomography (CECT) is a powerful 3D imaging tool for studying the native structure and organization of macromolecules inside single cells. For systematic recognition and recovery of macromolecular structures captured…

Computer Vision and Pattern Recognition · Computer Science 2018-07-04 Chang Liu , Xiangrui Zeng , Kaiwen Wang , Qiang Guo , Min Xu

Cellular Electron Cryotomography (CryoET) offers the ability to look inside cells and observe macromolecules frozen in action. A primary challenge for this technique is identifying and extracting the molecular components within the crowded…

Quantitative Methods · Quantitative Biology 2021-08-04 Muyuan Chen , Wei Dai , Ying Sun , Darius Jonasch , Cynthia Y He , Michael F. Schmid , Wah Chiu , Steven J Ludtke

Deep learning model trained by imbalanced data may not work satisfactorily since it could be determined by major classes and thus may ignore the classes with small amount of data. In this paper, we apply deep learning based imbalanced data…

Image and Video Processing · Electrical Eng. & Systems 2019-08-28 Ziqian Luo , Xiangrui Zeng , Zhipeng Bao , Min Xu

Cryo-electron microscopy (cryo-EM) emerges as a pivotal technology for determining the architecture of cells, viruses, and protein assemblies at near-atomic resolution. Traditional particle picking, a key step in cryo-EM, struggles with…

Biomolecules · Quantitative Biology 2024-04-17 Chentianye Xu , Xueying Zhan , Min Xu

Few-shot segmentation performance declines substantially when facing images from a domain different than the training domain, effectively limiting real-world use cases. To alleviate this, recently cross-domain few-shot segmentation (CD-FSS)…

Computer Vision and Pattern Recognition · Computer Science 2024-05-20 Jonas Herzog

In recent years, numerous domain adaptive strategies have been proposed to help deep learning models overcome the challenges posed by domain shift. However, even unsupervised domain adaptive strategies still require a large amount of target…

Image and Video Processing · Electrical Eng. & Systems 2024-07-11 Sumayya Inayat , Nimra Dilawar , Waqas Sultani , Mohsen Ali

Cryo-electron tomography (cryo-ET) has emerged as a powerful tool for studying the structural heterogeneity of proteins and their complexes, offering insights into macromolecular dynamics directly within cells. Driven by recent…

Biomolecules · Quantitative Biology 2025-07-01 Jackson Carrion , Joseph H. Davis

Few-shot classification aims to recognize novel categories with only few labeled images in each class. Existing metric-based few-shot classification algorithms predict categories by comparing the feature embeddings of query images with…

Computer Vision and Pattern Recognition · Computer Science 2020-03-10 Hung-Yu Tseng , Hsin-Ying Lee , Jia-Bin Huang , Ming-Hsuan Yang

In task-based few-shot learning paradigms, it is commonly assumed that different tasks are independently and identically distributed (i.i.d.). However, in real-world scenarios, the distribution encountered in few-shot learning can…

Computer Vision and Pattern Recognition · Computer Science 2025-04-10 Jiajun Chen , Hongpeng Yin , Yifu Yang

Cross-domain few-shot hyperspectral image classification focuses on learning prior knowledge from a large number of labeled samples from source domains and then transferring the knowledge to the tasks which contain few labeled samples in…

Computer Vision and Pattern Recognition · Computer Science 2023-12-27 Chun Liu , Longwei Yang , Zheng Li , Wei Yang , Zhigang Han , Jianzhong Guo , Junyong Yu
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