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Structural identifiability is a property of a differential model with parameters that allows for the parameters to be determined from the model equations in the absence of noise. The method of input-output equations is one method for…

Dynamical Systems · Mathematics 2022-01-28 Alexey Ovchinnikov , Gleb Pogudin , Peter Thompson

Parameter identifiability describes whether, for a given differential model, one can determine parameter values from model equations. Knowing global or local identifiability properties allows construction of better practical experiments to…

Mathematical Software · Computer Science 2021-07-02 Ilia Ilmer , Alexey Ovchinnikov , Gleb Pogudin

Observability is a modelling property that describes the possibility of inferring the internal state of a system from observations of its output. A related property, structural identifiability, refers to the theoretical possibility of…

Quantitative Methods · Quantitative Biology 2018-12-12 Alejandro F. Villaverde

Elimination of unknowns in a system of differential equations is often required when analysing (possibly nonlinear) dynamical systems models, where only a subset of variables are observable. One such analysis, identifiability, often relies…

Algebraic Geometry · Mathematics 2022-11-28 Ruiwen Dong , Christian Goodbrake , Heather A Harrington , Gleb Pogudin

Structural global parameter identifiability indicates whether one can determine a parameter's value from given inputs and outputs in the absence of noise. If a given model has parameters for which there may be infinitely many values, such…

Symbolic Computation · Computer Science 2022-04-05 Ilia Ilmer , Alexey Ovchinnikov , Gleb Pogudin , Pedro Soto

A key step in mechanistic modelling of dynamical systems is to conduct a structural identifiability analysis. This entails deducing which parameter combinations can be estimated from a given set of observed outputs. The standard…

Optimization and Control · Mathematics 2026-03-30 Johannes G Borgqvist , Alexander P Browning , Fredrik Ohlsson , Ruth E Baker

Reliable predictions from systems biology models require knowing whether parameters can be estimated from available data, and with what certainty. Identifiability analysis reveals whether parameters are learnable in principle (structural…

The increasing availability of experimental data has intensified interest in calibrating stochastic models, raising fundamental questions about parameter identifiability. Structural identifiability determines whether parameters can be…

Methodology · Statistics 2026-05-14 Arianna Ceccarelli , Alexander P. Browning , Ruth E. Baker

This work focuses on the question of how identifiability of a mathematical model, that is, whether parameters can be recovered from data, is related to identifiability of its submodels. We look specifically at linear compartmental models…

Algebraic Geometry · Mathematics 2019-05-27 Elizabeth Gross , Heather A. Harrington , Nicolette Meshkat , Anne Shiu

Structural identifiability concerns the question of which unknown parameters of a model can be recovered from (perfect) input-output data. If all of the parameters of a model can be recovered from data, the model is said to be identifiable.…

Systems and Control · Electrical Eng. & Systems 2025-06-11 Nicolette Meshkat , Alexey Ovchinnikov , Thomas Scanlon

A parameter of a mathematical model is structurally identifiable if it can be determined from noiseless experimental data. Here, we examine the identifiability properties of two important classes of linear compartmental models:…

Interpreting data with mathematical models is an important aspect of real-world industrial and applied mathematical modeling. Often we are interested to understand the extent to which a particular set of data informs and constrains model…

Methodology · Statistics 2025-03-06 Matthew J Simpson , Ruth E Baker

Identifiability concerns finding which unknown parameters of a model can be estimated from given input-output data. If some subset of the parameters of a model cannot be determined given input-output data, then we say the model is…

Algebraic Geometry · Mathematics 2014-11-03 Nicolette Meshkat , Seth Sullivant , Marisa Eisenberg

Researchers develop models to explain the unknowns. These models typically involve parameters that capture tangible quantities, the estimation of which is desired. Parameter identifiability investigates the recoverability of the unknown…

Optimization and Control · Mathematics 2024-07-01 Anuththara Sarathchandra , Azadeh Aghaeeyan , Pouria Ramazi

Parameter identifiability is a structural property of an ODE model for recovering the values of parameters from the data (i.e., from the input and output variables). This property is a prerequisite for meaningful parameter identification in…

Systems and Control · Electrical Eng. & Systems 2021-06-07 Alexey Ovchinnikov , Anand Pillay , Gleb Pogudin , Thomas Scanlon

Structural identifiability is an important property of parametric ODE models. When conducting an experiment and inferring the parameter value from the time-series data, we want to know if the value is globally, locally, or non-identifiable.…

Discrete Mathematics · Computer Science 2024-06-25 Natali Gogishvili

The parameter identifiability problem for a dynamical system is to determine whether the parameters of the system can be found from data for the outputs of the system. Verifying whether the parameters are identifiable is a necessary first…

Systems and Control · Electrical Eng. & Systems 2025-06-11 Alexey Ovchinnikov , Anand Pillay , Gleb Pogudin , Thomas Scanlon

Identifiability is a necessary condition for successful parameter estimation of dynamic system models. A major component of identifiability analysis is determining the identifiable parameter combinations, the functional forms for the…

Quantitative Methods · Quantitative Biology 2013-10-07 Marisa C. Eisenberg , Michael A. L. Hayashi

While hidden class models of various types arise in many statistical applications, it is often difficult to establish the identifiability of their parameters. Focusing on models in which there is some structure of independence of some of…

Statistics Theory · Mathematics 2009-09-01 Elizabeth S. Allman , Catherine Matias , John A. Rhodes

Structural identifiability is a property of an ODE model with parameters that allows for the parameters to be determined from continuous noise-free data. This is a natural prerequisite for practical identifiability. Conducting multiple…

Algebraic Geometry · Mathematics 2021-08-18 Alexey Ovchinnikov , Anand Pillay , Gleb Pogudin , Thomas Scanlon
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