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Networks are ubiquitous in biology where they encode connectivity patterns at all scales of organization, from molecular to the biome. However, biological networks are noisy due to the limitations of measurement technology and inherent…

Molecular Networks · Quantitative Biology 2018-08-16 Bo Wang , Armin Pourshafeie , Marinka Zitnik , Junjie Zhu , Carlos D. Bustamante , Serafim Batzoglou , Jure Leskovec

We consider the setting where many networks are observed on a common node set, and each observation comprises edge weights of a network, covariates observed at each node, and an overall response. The goal is to use the edge weights and node…

Methodology · Statistics 2023-08-23 Daniel Kessler , Keith Levin , Elizaveta Levina

Consider observing an undirected network that is `noisy' in the sense that there are Type I and Type II errors in the observation of edges. Such errors can arise, for example, in the context of inferring gene regulatory networks in genomics…

Machine Learning · Statistics 2014-01-03 Prakash Balachandran , Edoardo Airoldi , Eric Kolaczyk

In vitro neuronal culture is an important research platform in cellular and network neuroscience. However, neurons cultured on a homogeneous scaffold form dense, randomly connected networks and display excessively synchronized activity;…

Neurons and Cognition · Quantitative Biology 2024-05-30 Hakuba Murota , Hideaki Yamamoto , Nobuaki Monma , Shigeo Sato , Ayumi Hirano-Iwata

There is increasing interest in learning a set of small outcome-relevant subgraphs in network-predictor regression. The extracted signal subgraphs can greatly improve the interpretation of the association between the network predictor and…

Methodology · Statistics 2019-03-27 Lu Wang , Zhengwu Zhang , David Dunson

One of the main current issues in Neurobiology concerns the understanding of interrelated spiking activity among multineuronal ensembles and differences between stimulus-driven and spontaneous activity in neurophysiological experiments.…

Neurons and Cognition · Quantitative Biology 2017-10-13 Ludmila Brochini , Antonio Galves , Pierre Hodara , Guilherme Ost , Christophe Pouzat

Neural networks have seen limited use in prediction for high-dimensional data with small sample sizes, because they tend to overfit and require tuning many more hyperparameters than existing off-the-shelf machine learning methods. With…

Machine Learning · Statistics 2020-05-12 Jean Feng , Noah Simon

Network datasets appear across a wide range of scientific fields, including biology, physics, and the social sciences. To enable data-driven discoveries from these networks, statistical inference techniques like estimation and hypothesis…

Methodology · Statistics 2026-02-19 Arpan Kumar , Minh Tang , Srijan Sengupta

A computer model is described which is used to assess the dynamical complexity of a class of networks of spiking neurons with small-world properties. Networks are constructed by forming an initially segregated set of highly intra-connected…

Biological Physics · Physics 2009-11-13 Murray Shanahan

We address the questions of identifying pairs of interacting neurons from the observation of their spiking activity. The neuronal network is modeled by a system of interacting point processes with memory of variable length. The influence of…

Statistics Theory · Mathematics 2021-06-22 Emilio De Santis , Antonio Galves , Giovanna Nappo , Mauro Piccioni

While both cost-sensitive learning and online learning have been studied extensively, the effort in simultaneously dealing with these two issues is limited. Aiming at this challenge task, a novel learning framework is proposed in this…

Machine Learning · Computer Science 2013-10-31 Boyu Wang , Joelle Pineau

In increasingly many settings, data sets consist of multiple samples from a population of networks, with vertices aligned across these networks. For example, brain connectivity networks in neuroscience consist of measures of interaction…

Statistics Theory · Mathematics 2021-05-11 Keith Levin , Asad Lodhia , Elizaveta Levina

Cellular neural circuit and networks consisting of interconnected neurons and glia are ulti- mately responsible for the information processing associated with information processing in the brain. While there are major efforts aimed at…

Neurons and Cognition · Quantitative Biology 2015-05-18 Marius Buibas , Gabriel A. Silva

This paper presents a Bayesian approach to learning the connectivity structure of a group of neurons from data on configuration frequencies. A major objective of the research is to provide statistical tools for detecting changes in firing…

Machine Learning · Computer Science 2013-02-18 Kathryn Blackmond Laskey , Laura Martignon

Neural networks are usually not the tool of choice for nonparametric high-dimensional problems where the number of input features is much larger than the number of observations. Though neural networks can approximate complex multivariate…

Methodology · Statistics 2019-06-25 Jean Feng , Noah Simon

Performing multiple experiments is common when learning internal mechanisms of complex systems. These experiments can include perturbations to parameters or external disturbances. A challenging problem is to efficiently incorporate all…

Systems and Control · Computer Science 2020-08-25 Zuogong Yue , Johan Thunberg , Wei Pan , Lennart Ljung , Jorge Goncalves

A major challenge in neuroimaging is understanding the mapping of neurophysiological dynamics onto cognitive functions. Traditionally, these maps have been constructed by examining changes in the activity magnitude of regions related to…

Neuronal dynamics are fundamentally constrained by the underlying structural network architecture, yet much of the details of this synaptic connectivity are still unknown even in neuronal cultures in vitro. Here we extend a previous…

Neurons and Cognition · Quantitative Biology 2017-02-08 Javier G. Orlandi , Olav Stetter , Jordi Soriano , Theo Geisel , Demian Battaglia

Community structure is common in many real networks, with nodes clustered in groups sharing the same connections patterns. While many community detection methods have been developed for networks with binary edges, few of them are applicable…

Methodology · Statistics 2023-03-13 Andressa Cerqueira , Elizaveta Levina

An overarching objective in contemporary statistical network analysis is extracting salient information from datasets consisting of multiple networks. To date, considerable attention has been devoted to node and network clustering, while…

Methodology · Statistics 2025-08-19 Wenlong Jiang , Chris McKennan , Jesús Arroyo , Joshua Cape